Gene: Dact3

Order

Name dishevelled-binding antagonist of beta-catenin 3

Synonyms EG666671

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:3654828    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Dact3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dact3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased total body fat amount Dact3tm1b(KOMP)Wtsi HOM Male postnatal 2.24E-5
increased lean body mass Dact3tm1b(KOMP)Wtsi HOM Male postnatal 2.66E-5
increased red blood cell distribution width Dact3tm1b(KOMP)Wtsi HOM Male postnatal 4.92E-5
decreased circulating serum albumin level Dact3tm1b(KOMP)Wtsi HOM Male postnatal 6.74E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No (2/2)
Blood vessel 2 No (2/2)
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Eye 2 No
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle tissue 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (22)
  • Dact3tm1b(KOMP)Wtsi
    mammary gland, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    gall bladder, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    peyer's patch, HET, Female, WTSI

show all 22 images

trunk (16)
  • Dact3tm1b(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    gall bladder, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    peyer's patch, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    thymus, HET, Male, WTSI

show all 16 images

digestive system (5)
  • Dact3tm1b(KOMP)Wtsi
    gall bladder, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    peyer's patch, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    oesophagus, stomach, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    small intestine, HET, Female, WTSI
immune system (4)
  • Dact3tm1b(KOMP)Wtsi
    peyer's patch, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    lymph node, mesenteric lymph node, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    thymus, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    spleen, HET, Female, WTSI
nervous system (3)
  • Dact3tm1b(KOMP)Wtsi
    peripheral nervous system, trigeminal V nerve, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    spinal cord, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    hippocampus, brain, HET, Female, WTSI
reproductive system (3)
  • Dact3tm1b(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
cardiovascular system (2)
  • Dact3tm1b(KOMP)Wtsi
    aorta, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    blood vessel, HET, Female, WTSI
exocrine system (2)
  • Dact3tm1b(KOMP)Wtsi
    mammary gland, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
integumental system (2)
  • Dact3tm1b(KOMP)Wtsi
    mammary gland, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    skin, HET, Female, WTSI
respiratory system (2)
  • Dact3tm1b(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    lung, HET, Female, WTSI
endocrine system (1)
  • Dact3tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
urinary system (1)
  • Dact3tm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    36 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Lateral Orientation
    26 Images
  • X-ray: XRay Images Skull Lateral Orientation
    13 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • Anti-nuclear antibody assay
    6 Images
  • Eye Morphology: Images Ophthalmoscopy
    1 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (62)
  • Dact3tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    HOM, Female, WTSI

show all 62 images

Histology Slide (5)
  • Dact3tm1b(KOMP)Wtsi
    TS20 forelimb, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    TS20 chorioallantoic placenta, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    TS20 liver, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    TS20 oral cavity, HET, Male, WTSI
  • Dact3tm1b(KOMP)Wtsi
    TS20 mandibular process, HET, Male, WTSI
Eye Morphology (2)
  • Dact3tm1b(KOMP)Wtsi
    persistence of hyaloid vascular system, HOM, Female, WTSI
  • Dact3tm1b(KOMP)Wtsi
    corneal opacity, HOM, Female, WTSI
Dysmorphology (1)
  • Dact3tm1b(KOMP)Wtsi
    abnormal tail morphology, HOM, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dact3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dact3tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Dact3tm114992(L1L2_Bact_P)
Vector
Gene