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Gene: Cdnf MGI:3606576

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cerebral dopamine neurotrophic factor
Synonyms:
Armetl1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cdnf mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cdnf by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Neurodegeneration Due To Cerebral Folate Transport Deficiency
Neurodegeneration OMIM:613068
Ceroid Lipofuscinosis, Neuronal, 7
Cerebellar atrophy, Optic atrophy, Cerebral atrophy, Neurodegeneration OMIM:610951
Pure Autonomic Failure
Abnormality of circulating catecholamine level, Abnormal autonomic nervous system physiology, Ort... ORPHA:441
Diaminopentanuria
Neurodegeneration OMIM:222350
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Paraganglioma of head and neck, Glomus tympan... OMIM:168000
Pheochromocytoma/Paraganglioma Syndrome 3
Extraadrenal pheochromocytoma, Chemodectoma, Adrenal pheochromocytoma, Glomus jugular tumor, Para... OMIM:605373
Spastic Paraplegia 35, Autosomal Recessive, With Or Without Neurodegeneration
Cerebellar atrophy, Optic atrophy, Neurodegeneration, Atrophy/Degeneration affecting the brainstem OMIM:612319
Neurodegeneration With Brain Iron Accumulation 5
Cerebellar atrophy, Neurodegeneration, Abnormal autonomic nervous system physiology, Cerebral atr... OMIM:300894
Neurodegeneration With Brain Iron Accumulation 2A
Cerebellar atrophy, Decreased nerve conduction velocity, Optic atrophy, Cerebral atrophy, Neurode... OMIM:256600
Combined Oxidative Phosphorylation Defect Type 29
Optic neuropathy, Axonal degeneration, Neurodegeneration, Abnormal autonomic nervous system physi... ORPHA:478029
Pcna-Related Progressive Neurodegenerative Photosensitivity Syndrome
Cerebellar atrophy, Neurodegeneration ORPHA:438134
Krabbe Disease
Decreased nerve conduction velocity, Diffuse cerebral atrophy, Optic atrophy, Neurodegeneration OMIM:245200
Neurodegeneration, Childhood-Onset, With Brain Atrophy
Cerebellar atrophy, Neurodegeneration, Cerebral cortical atrophy, Cerebral atrophy OMIM:617672
Leukoencephalopathy, Progressive, With Ovarian Failure
Cerebellar atrophy, Neurodegeneration OMIM:615889
Neurodegeneration With Brain Iron Accumulation 6
Neurodegeneration OMIM:615643
Hsd10 Disease, Infantile Type
Diffuse cerebral atrophy, Optic atrophy, Cerebral atrophy, Frontotemporal cerebral atrophy, Neuro... ORPHA:391428
Cerebrooculofacioskeletal Syndrome 1
Cerebellar atrophy, Diffuse cerebral atrophy, Neurodegeneration, Brain atrophy OMIM:214150
Combined Oxidative Phosphorylation Deficiency 24
Cerebellar atrophy, Neuronal loss in central nervous system, Optic atrophy, Neurodegeneration OMIM:616239
Spastic Paraplegia 79B, Autosomal Recessive
Cerebellar atrophy, Optic atrophy, Cerebral atrophy, Neurodegeneration OMIM:615491
Neurodevelopmental Disorder With Dysmorphic Facies And Ischiopubic Hypoplasia
Neurodegeneration OMIM:620210
Amyotrophic Lateral Sclerosis
Motor neuron atrophy, Amyotrophic lateral sclerosis, Neurodegeneration ORPHA:803
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Cerebellar atrophy, Neurodegeneration, Cerebral cortical atrophy, Cerebral atrophy OMIM:615157
Cerebral Visual Impairment
Optic disc pallor, Optic nerve hypoplasia, Optic atrophy, Central nervous system degeneration, In... ORPHA:447788
Adrenoleukodystrophy
Hypogonadism, Primary adrenal insufficiency, Neurodegeneration OMIM:300100
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Premature thelarche, Optic atrophy, Cerebral atrophy, Neurodegeneration, Hypothyroidism, Prematur... OMIM:616878
Multiple System Atrophy 1, Susceptibility To
Orthostatic hypotension, Neurodegeneration, Abnormal autonomic nervous system physiology OMIM:146500
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis
Neurodegeneration, Optic atrophy, Periventricular heterotopia OMIM:618476
Gm2 Gangliosidosis, Ab Variant
Neurodegeneration, Cerebral atrophy ORPHA:309246
Von Hippel-Lindau Disease
Papilledema, Pancreatic islet cell adenoma, Pancreatic endocrine tumor, Adrenal pheochromocytoma,... ORPHA:892
Neurodegeneration With Brain Iron Accumulation 4
Abnormal lower motor neuron morphology, Cerebellar atrophy, Optic atrophy, Neurodegeneration OMIM:614298
Neurodegeneration With Brain Iron Accumulation 2B
Cerebellar atrophy, Optic atrophy, Cerebral atrophy, Neurodegeneration OMIM:610217
Gm2-Gangliosidosis, Ab Variant
Neurodegeneration, Cerebral atrophy OMIM:272750
Mucopolysaccharidosis, Type Ii
Papilledema, Neurodegeneration OMIM:309900
Neurodegeneration With Brain Iron Accumulation 3
Neurodegeneration OMIM:606159
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Neurodegeneration, Cerebral atrophy OMIM:618321
Ataxia-Telangiectasia-Like Disorder 2
Cerebellar atrophy, Neurodegeneration OMIM:615919
Chediak-Higashi Syndrome
Decreased nerve conduction velocity, Neurodegeneration OMIM:214500
Pyruvate Dehydrogenase E2 Deficiency
Neurodegeneration ORPHA:79244
Mucopolysaccharidosis, Type Vii
Neurodegeneration OMIM:253220
Hurler Syndrome
Neurodegeneration OMIM:607014
Neurodegeneration With Brain Iron Accumulation 1
Neurodegeneration, Cerebral degeneration, Optic atrophy, Global brain atrophy OMIM:234200
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Neurodegeneration, Delayed puberty OMIM:619475
Nijmegen Breakage Syndrome
Neurodegeneration OMIM:251260
Primrose Syndrome
Diabetes mellitus, Hypergonadotropic hypogonadism, Neurodegeneration, Delayed puberty, Hypothyroi... OMIM:259050

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cdnf

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdnf.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Frontiers in endocrinology (November 2019) Cdnftm1a(KOMP)Wtsi PMC6851024

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MGI Allele Allele Type Produced
Cdnfem1(IMPC)Hmgu Exon Deletion Mice
Cdnftm33935(L1L2_st1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cdnftm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cdnftm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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