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Genes Phenotypes Help, News, Blog

Gene: Bpi MGI:3045315

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Gene Summary

Name:
bactericidal permeablility increasing protein
Synonyms:
Bpifd1,  9230105K17Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Forepaw

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

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Human diseases caused by Bpi mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bpi

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bpi.

There are 14 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance. American journal of physiology. Lung cellular and molecular physiology (October 2023) Bpifb1tm1a(KOMP)Wtsi 37847709
Regional Differences in Mucociliary Clearance in the Upper and Lower Airways. Frontiers in physiology (March 2022) Bpifb1tm1a(KOMP)Wtsi PMC8959816
BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus. Theranostics (October 2021) Bpitm1a(EUCOMM)Wtsi PMC8581436
Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis. Frontiers in immunology (April 2021) Bpiem1(IMPC)J PMC8107240
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi PMC7263671
The parotid secretory protein BPIFA2 is a salivary surfactant that affects LPS action. Experimental physiology (May 2020) Bpifa2tm1(KOMP)Vlcg 32390232
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi PMC5827107
Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. Genetics (August 2017) Bpifb1tm1a(KOMP)Wtsi 28851744
BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI. Journal of the American Society of Nephrology : JASN (August 2017) Bpifa2tm1(KOMP)Vlcg 28775000
SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice. American journal of respiratory cell and molecular biology (April 2012) Bpifa1tm1(KOMP)Vlcg PMC3423460
SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. The American journal of pathology (May 2011) Bpifa1tm1(KOMP)Vlcg PMC3081195

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Bpiem1(IMPC)J Exon Deletion Mice
Bpitm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bpitm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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