Gene: Pfkfb4

Order

Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2687284    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Pfkfb4

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Pfkfb4 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
female infertility Pfkfb4tm1b(KOMP)Wtsi HOM Female postpartum stage 0.0
abnormal vocalization Pfkfb4tm1b(KOMP)Wtsi HOM Male postnatal 2.74E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No (2/415) (3/4)
Aorta 3 No
Blood 3 No
Bone marrow 3 No
Brain 3 No (2/4)
Brainstem 3 No
Brown adipose tissue 3 No
Cartilage tissue 3 No
Cecum 3 No (12/383) (2/4)
Cerebellum 3 No (4/4)
Cerebral cortex 3 No
Chest bone 3 No (2/4)
Colon 3 No (12/127) (2/4)
Diaphragm 3 No
Duodenum 3 No (2/127) (2/4)
Epididymis 3 No (18/134) (2/4)
Esophagus 3 No (7/415) (4/4)
Eye 3 No (1/4)
Gall bladder 3 No (1/4)
Gonadal fat pad 3 No
Harderian gland 3 No
Heart 3 No
Hindlimb 3 No
Hippocampus 3 No
Hypothalamus 3 No
Ileum 3 No (14/127) (2/4)
Jejunum 3 No (6/127) (2/4)
Kidney 3 No (18/584) (3/4)
Large intestine 3 No (10/584)
Liver 3 No
Lower urinary tract 3 No
Lung 3 No (2/4)
Lymph node 3 No
Mammary gland 3 No
Mesenteric lymph node 3 No
Mesenteric adipose tissue 3 No
Midbrain 3 No (4/4)
Olfactory lobe 3 No (4/4)
Ovary 3 No (1/584)
Oviduct 3 No (1/4)
Pancreas 3 No (5/584)
Parathyroid gland 3 No (2/4)
Parotid gland 3 No
Penis 3 No (1/4)
Peripheral nervous system 3 No
Peyer's patch 3 No
Pituitary gland 3 No (2/4)
Prostate gland 3 No (12/584) (1/4)
Quadriceps 3 No
Sciatic nerve 3 No (1/4)
Skeletal muscle 3 No
Skin 3 No (3/4)
Small intestine 3 No (9/584)
Spinal cord 3 No (4/4)
Spleen 3 No (2/584)
Stomach 3 No (12/584) (4/4)
Stomach pyloric region 3 No
Striatum 3 No
Sublingual gland 3 No
Submandibular gland 3 No (2/132)
Testis 3 No (2/584) (1/4)
Thymus 3 No
Thyroid gland 3 No (15/584)
Tongue 3 No (5/127) (1/4)
Trachea 3 No (1/4)
Trigeminal V nerve 3 No (2/4)
Urinary bladder 3 No (4/4)
Uterus 3 No (2/4)
Vagina 3 No (1/4)
Vas deferens 3 No (15/388) (2/4)
Vascular system 3 No
Vesicular gland 3 No (2/4)
White adipose tissue 3 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system limb digestive system reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    82 Images
  • X-ray: XRay Images Lateral Orientation
    48 Images
  • DSS Histology
    7 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • X-ray: XRay Images Skull Lateral Orientation
    13 Images
  • X-ray: XRay Images Forepaw
    14 Images
Legacy Phenotype Associated Images
Xray (70)
  • Pfkfb4tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Pfkfb4tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Pfkfb4tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Pfkfb4tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Pfkfb4tm1a(KOMP)Wtsi
    HOM, Male, WTSI

show all 70 images

Eye Morphology (2)
  • Pfkfb4tm1a(KOMP)Wtsi
    retinal hemorrhage, HOM, Female, WTSI
  • Pfkfb4tm1a(KOMP)Wtsi
    left eye, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Pfkfb4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Pfkfb4tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue