Gene: Ric8b

Order

Name RIC8 guanine nucleotide exchange factor B

Synonyms
  • Ric-8
  • Ric-8b

Status ES CellsMice
tm1a
Mice
tm1c
Mice
tm1b
phenotype data available

Links MGI:2682307    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Ric8b

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ric8b data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Ric8btm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
decreased bone mineral density Ric8btm1b(EUCOMM)Hmgu HET Female Male postnatal 2.8E-8
decreased lean body mass Ric8btm1b(EUCOMM)Hmgu HET Female Male postnatal 5.08E-8
decreased bone mineral content Ric8btm1b(EUCOMM)Hmgu HET Female Male postnatal 5.79E-8
increased leukocyte cell number Ric8btm1b(EUCOMM)Hmgu HET Female Male postnatal 1.76E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (1/2)
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No (2/2)
Mammary gland 2 No (1/2)
Olfactory lobe 2 No (2/2)
Oral epithelium 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (3/4)
Ear 2 (1/485) (2/4)
Embryo 2 (1/485) (4/4)
Eye 2 (1/485) (3/4)
Foot 2 (1/485) (2/4)
Forebrain 2 (1/485) (3/4)
Forelimb 2 (1/485) (3/4)
Hand 2 (1/485) (2/4)
Head 2 (5/485) (3/4)
Heart 2 (1/485) (2/4)
Hindbrain 2 (6/485) (3/4)
Hindlimb 2 (1/485) (3/4)
Liver 2 (1/485) (2/4)
Lung 2 (1/485) (2/4)
Mandibular process 2 (1/485) (2/4)
Maxillary process 2 (1/485) (2/4)
Midbrain 2 (1/485) (3/4)
Oral cavity 2 (1/485) (2/4)
Skin 2 (1/485) (2/4)
Tail 2 (1/485) (3/4)
Tail somite 2 (1/485) (3/4)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Echo: M-Mode Images
    28 Images
  • Adult LacZ: LacZ Images Wholemount
    22 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    9 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Ric8btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ric8btm1c(EUCOMM)Hmgu Wild type floxed exon (post-Flp)
Vector
Gene
Ric8btm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Ric8btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene