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Gene: Rapgef2 MGI:2659071

Gene Summary

Name:

Rap guanine nucleotide exchange factor (GEF) 2

Synonyms:

Pdzgef1, nRapGEP, CNRasGEF, RA-GEF-1, 5830453M24Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype	Allele	Zyg	Life Stage	P Value
preweaning lethality, complete penetrance	Rapgef2^em1(IMPC)H	HOM	Early adult	0.00
abnormal retina morphology	Rapgef2^em1(IMPC)H	HET	Early adult	1.15×10^-16
increased circulating bilirubin level	Rapgef2^em1(IMPC)H	HET	Early adult	3.51×10^-06
embryonic lethality prior to tooth bud stage	Rapgef2^em1(IMPC)H	HOM	E12.5	0.00
decreased exploration in new environment	Rapgef2^em1(IMPC)H	HET	Early adult	6.87×10^-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

OPT E9.5

Embryo reconstruction

5 Images

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Human diseases caused by Rapgef2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Rapgef2 (1 diseases)
Human diseases predicted to be associated with Rapgef2 (322 diseases)

The table below shows human diseases associated to Rapgef2 by orthology or direct annotation.

Disease	Similarity of phenotypes	Matching phenotypes	Source
Epilepsy, Familial Adult Myoclonic, 7			OMIM:618075

The table below shows human diseases predicted to be associated to Rapgef2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Retinal Dysplasia, Primary	Retinal dysplasia, Falciform retinal fold	OMIM:312550
Crigler-Najjar Syndrome Type 2	Neonatal hyperbilirubinemia, Unconjugated hyperbilirubinemia	ORPHA:79235
Congenital Herpes Simplex Virus Infection	Hydranencephaly, Intrauterine growth retardation, Premature birth, Microcephaly	ORPHA:293
Malaria	Retinopathy, Cognitive impairment, Hyperbilirubinemia, Elevated circulating C-reactive protein co...	ORPHA:673
Hyperbilirubinemia, Transient Familial Neonatal	Neonatal unconjugated hyperbilirubinemia	OMIM:237900
Jaundice, Familial Obstructive, Of Infancy	Neonatal hyperbilirubinemia	OMIM:308600
Crigler-Najjar Syndrome, Type Ii	Unconjugated hyperbilirubinemia	OMIM:606785
Hyperbilirubinemia, Conjugated, Type Iii	Conjugated hyperbilirubinemia	OMIM:237550
Stargardt Disease 1	Macular degeneration, Retinitis pigmentosa inversa, Bull's eye maculopathy	OMIM:248200
Anencephaly 1	Anencephaly, Spina bifida	OMIM:206500
Spina Bifida-Hypospadias Syndrome	Spina bifida, Spinal dysraphism	ORPHA:3176
Hydrocephalus, Congenital, 3, With Brain Anomalies	Polyhydramnios, Hydrocephalus, Cerebellar hypoplasia, Holoprosencephaly, Cerebellar agenesis, Hyd...	OMIM:617967
Glutathione Peroxidase Deficiency	Neonatal hyperbilirubinemia	OMIM:614164
Hypercholanemia, Familial, 2	Increased serum bile acid concentration, Unconjugated hyperbilirubinemia	OMIM:619256
Hemolytic Anemia Due To Glutathione Reductase Deficiency	Hyperbilirubinemia	OMIM:618660
Crigler-Najjar Syndrome Type 1	Memory impairment, Neonatal hyperbilirubinemia, Unconjugated hyperbilirubinemia	ORPHA:79234
Neural Tube Defects, Folate-Sensitive	Spinal dysraphism	OMIM:601634
Neural Tube Defects, Susceptibility To	Myelomeningocele, Spina bifida occulta, Anencephaly, Hydrocephalus	OMIM:182940
Hyperbilirubinemia, Rotor Type	Conjugated hyperbilirubinemia	OMIM:237450
Dubin-Johnson Syndrome	Conjugated hyperbilirubinemia	OMIM:237500
Crigler-Najjar Syndrome, Type I	Unconjugated hyperbilirubinemia	OMIM:218800
Cholestasis, Progressive Familial Intrahepatic, 11	Abnormal circulating bilirubin concentration, Increased serum bile acid concentration	OMIM:619874
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome	Anencephaly, Spina bifida	ORPHA:2476
Frontal Encephalocele	Encephalocele, Cerebral calcification, Spina bifida, Hydrocephalus, Aplasia/Hypoplasia of the cor...	ORPHA:1931
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs	Hydranencephaly, Truncus arteriosus, Microcephaly	OMIM:601355
Schisis Association	Encephalocele, Premature birth, Spina bifida, Microcephaly, Anencephaly	ORPHA:63862
Isolated Anencephaly/Exencephaly	Anencephaly	ORPHA:1048
Diprosopus	Anencephaly	ORPHA:1681
Ophthalmoplegia, External, And Myopia	Spina bifida	OMIM:311000
Anencephaly 2	Anencephaly	OMIM:619452
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome	Decreased fetal movement, Aplasia/Hypoplasia of the cerebellum, Microcephaly, Aplasia/Hypoplasia ...	ORPHA:2570
Exudative Vitreoretinopathy 7	Retinal detachment, Exudative vitreoretinopathy, Retinal hole, Retinal fold, Retinal degeneration	OMIM:617572
Placental Insufficiency	Intrauterine growth retardation, Abnormal umbilical cord blood vessel morphology, Abnormal placen...	ORPHA:439167
Hydrolethalus Syndrome 2	Agenesis of corpus callosum, Hydrocephalus, Anencephaly	OMIM:614120
Meckel Syndrome, Type 4	Encephalocele, Agenesis of cerebellar vermis, Microcephaly, Hydrocephalus, Meningocele, Anencepha...	OMIM:611134
Aminopterin/Methotrexate Embryofetopathy	Encephalocele, Microcephaly, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Aplasia/...	ORPHA:1908
Cholestasis, Progressive Familial Intrahepatic, 12	Conjugated hyperbilirubinemia, Increased serum bile acid concentration, Hyperbilirubinemia	OMIM:620010
Acalvaria	Aplasia/Hypoplasia of the cerebellum, Hydrocephalus, Holoprosencephaly, Spina bifida	ORPHA:945
Retinoschisis 1, X-Linked, Juvenile	Retinal detachment, Retinal atrophy, Retinal pigment epithelial atrophy, Mizuo phenomenon, Macula...	OMIM:312700
Exudative Vitreoretinopathy 3	Retinal detachment, Retinal exudate, Exudative vitreoretinopathy, Retinal hole, Retinal fold	OMIM:605750
Rotor Syndrome	Conjugated hyperbilirubinemia, Hyperbilirubinemia	ORPHA:3111
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome	Premature birth, Polyhydramnios, Microcephaly, Hydrocephalus, Hypoplasia of the brainstem, Cerebe...	OMIM:225790
Red Cell Phospholipid Defect With Hemolysis	Hyperbilirubinemia	OMIM:179700
Microhydranencephaly	Microcephaly, Hypoplasia of the brainstem, Cerebellar hypoplasia, Hydranencephaly, Pachygyria, Ag...	OMIM:605013
Craniorachischisis	Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism	ORPHA:63260
Distal Deletion 13Q	Encephalocele, Microcephaly, Anencephaly, Aplasia/Hypoplasia of the corpus callosum, Holoprosence...	ORPHA:1590
Meckel Syndrome, Type 2	Encephalocele, Meningocele, Anencephaly, Intrauterine growth retardation, Dandy-Walker malformation	OMIM:603194
Late-Onset Retinal Degeneration	Sub-RPE deposits, Choroidal neovascularization, Chorioretinal degeneration, Retinopathy, Retinal ...	OMIM:605670
Edinburgh Malformation Syndrome	Neonatal hyperbilirubinemia	OMIM:129850
X-Linked Retinal Dysplasia	Abnormal retinal vascular morphology, Abnormality of retinal pigmentation, Retinal dysplasia	ORPHA:1852
Gilbert Syndrome	Unconjugated hyperbilirubinemia	OMIM:143500
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly	Hypoplasia of the brainstem, Stillbirth, Cerebellar hypoplasia, Neonatal death, Hydranencephaly, ...	OMIM:236500
Trichomegaly-Retina Pigmentary Degeneration-Dwarfism Syndrome	Pigmentary retinopathy, Neonatal hyperbilirubinemia, Retinal degeneration	ORPHA:3363
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases	Spina bifida	OMIM:211960
Familial Drusen	Abnormality of retinal pigmentation, Macular drusen, Peripapillary chorioretinal atrophy, Choroid...	ORPHA:75376
Cholestasis, Progressive Familial Intrahepatic, 10	Conjugated hyperbilirubinemia, Hypoalbuminemia, Increased serum bile acid concentration, Hypercho...	OMIM:619868
Retinopathy, Pericentral Pigmentary, Dominant	Bone spicule pigmentation of the retina, Retinal atrophy, Retinal dystrophy, Pigmentary retinopat...	OMIM:180210
Meckel Syndrome, Type 10	Occipital encephalocele, Anencephaly, Cerebellar hypoplasia, Dandy-Walker malformation	OMIM:614175
Hydrolethalus	Premature birth, Absent septum pellucidum, Polyhydramnios, Hydrocephalus, Anencephaly, Agenesis o...	ORPHA:2189
Nevus Comedonicus Syndrome	Spina bifida occulta, Spina bifida, Microcephaly	ORPHA:64754
Meckel Syndrome, Type 5	Occipital encephalocele, Anencephaly	OMIM:611561
Birdshot Chorioretinopathy	Retinal detachment, Optic disc pallor, Abnormal chorioretinal morphology, Choroidal neovasculariz...	ORPHA:179
Growth Delay-Intellectual Disability-Hepatopathy Syndrome	Elevated hepatic transaminase, Cholestasis, Hepatosplenomegaly, Hepatic fibrosis, Esophagitis, In...	ORPHA:541423
Chiari Malformation Type Ii	Spina bifida, Myelomeningocele, Hydrocephalus, Cervical myelopathy, Syringomyelia, Agenesis of co...	OMIM:207950
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency	Intrauterine growth retardation, Severe intrauterine growth retardation, Small placenta, Microcep...	ORPHA:73272
Aplasia Cutis Congenita	Spinal dysraphism	ORPHA:1114
Hyperbilirubinemia, Shunt, Primary	Hyperbilirubinemia	OMIM:237800
Caudal Duplication	Myelomeningocele, Spinal cord lesion, Spina bifida	ORPHA:1756
Citrullinemia, Type Ii, Neonatal-Onset	Hypertyrosinemia, Decreased HDL cholesterol concentration, Hypertriglyceridemia, Conjugated hyper...	OMIM:605814
Iniencephaly	Encephalocele, Spina bifida, Polyhydramnios, Myelomeningocele, Hydrocephalus, Anencephaly, Spinal...	ORPHA:63259
Cerebroretinal Microangiopathy With Calcifications And Cysts 1	Anemia, Intestinal bleeding, Bone marrow hypocellularity, Intrauterine growth retardation, Oral l...	OMIM:612199
Silver-Russell Syndrome Due To A Point Mutation	Intrauterine growth retardation, Small placenta, Oligohydramnios	ORPHA:397590
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Increased total bilirubin	OMIM:174050
Retinitis Pigmentosa 70	Optic disc pallor, Macular degeneration, Rod-cone dystrophy, Retinal degeneration, Attenuation of...	OMIM:615922
Chromosome 13Q33-Q34 Deletion Syndrome	Encephalocele, Microcephaly, Patent ductus arteriosus, Anencephaly, Agenesis of corpus callosum, ...	OMIM:619148
Cerebrocostomandibular Syndrome	Cerebral calcification, Spina bifida, Microcephaly, Myelomeningocele, Meningocele, Porencephalic ...	ORPHA:1393
Acropectorovertebral Dysplasia	Spina bifida	ORPHA:957
Vacterl/Vater Association	Occipital encephalocele, Premature birth, Polyhydramnios, Anencephaly, Single umbilical artery, I...	ORPHA:887
Thoracoabdominal Syndrome	Patent ductus arteriosus, Anencephaly, Hydrocephalus	OMIM:313850
Short-Rib Thoracic Dysplasia 14 With Polydactyly	Cerebellar vermis hypoplasia, Polyhydramnios, Hydrocephalus, Anencephaly, Hydrops fetalis, Hypopl...	OMIM:616546
Isolated Klippel-Feil Syndrome	Spina bifida	ORPHA:2345
Liver Disease, Severe Congenital	Chronic gastritis, Cardiomegaly, Biliary hyperplasia, Leukopenia, Protein-losing enteropathy, Lym...	OMIM:619991
Limb Body Wall Complex	Encephalocele, Spina bifida, Myelomeningocele, Hydrocephalus, Anencephaly, Abnormal spinal cord m...	ORPHA:2369
Biliary Atresia, Extrahepatic	Unconjugated hyperbilirubinemia, Hyperbilirubinemia, Increased total bilirubin	OMIM:210500
Pelvis-Shoulder Dysplasia	Hydranencephaly, Hydrocephalus, Spina bifida	ORPHA:2839
Retinitis Pigmentosa 13	Bone spicule pigmentation of the retina, Optic disc drusen, Perifoveal ring of hyperautofluoresce...	OMIM:600059
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13	Communicating hydrocephalus, Occipital encephalocele, Agenesis of cerebellar vermis, Absent septu...	OMIM:615287
Camptodactyly Syndrome, Guadalajara Type 1	Intrauterine growth retardation, Spina bifida, Microcephaly	ORPHA:1327
De Barsy Syndrome	Ventricular septal defect, Patent ductus arteriosus, Cutis laxa, Excessive wrinkled skin, High pa...	ORPHA:2962
Short-Rib Thoracic Dysplasia 12	Polyhydramnios, Splenomegaly, Patent ductus arteriosus, Hydrocephalus, Anencephaly, Holoprosencep...	OMIM:269860
Amish Lethal Microcephaly	Decreased fetal movement, Cerebellar vermis hypoplasia, Spina bifida, Microcephaly, Lissencephaly...	ORPHA:99742
Cutis Laxa, Autosomal Dominant 3	Intrauterine growth retardation, Premature skin wrinkling, Cutis laxa, Dermal translucency	OMIM:616603
Cholestasis, Benign Recurrent Intrahepatic, 1	Conjugated hyperbilirubinemia, Increased serum bile acid concentration	OMIM:243300
Pentalogy Of Cantrell	Encephalocele, Hydrocephalus, Anencephaly, Polysplenia	ORPHA:1335
Bile Acid Synthesis Defect, Congenital, 5	Increased serum bile acid concentration, Increased total iron binding capacity, Hyperbilirubinemia	OMIM:616278
Hepatic Veno-Occlusive Disease	Increased total bilirubin	ORPHA:890
Cutis Laxa, Autosomal Recessive, Type Iiib	Pyloric stenosis, Cutis laxa, Excessive wrinkled skin, Intrauterine growth retardation, Dermal tr...	OMIM:614438
Combined Osteogenesis Imperfecta And Ehlers-Danlos Syndrome 1	Atrial septal defect, Dermal translucency	OMIM:619115
Isolated Polycystic Liver Disease	Increased total bilirubin	ORPHA:2924
Meckel Syndrome, Type 6	Occipital encephalocele, Hydrocephalus, Anencephaly	OMIM:612284
Neu-Laxova Syndrome 1	Decreased fetal movement, Spina bifida, Polyhydramnios, Fetal akinesia sequence, Patent ductus ar...	OMIM:256520
Meckel Syndrome, Type 1	Accessory spleen, Occipital encephalocele, Microcephaly, Asplenia, Large placenta, Patent ductus ...	OMIM:249000
Anophthalmia Plus Syndrome	Spina bifida	ORPHA:1104
Megaloblastic Anemia, Folate-Responsive	Increased circulating ferritin concentration, Hyperbilirubinemia, Hyperhomocystinemia	OMIM:601775
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome	Patent ductus arteriosus, Spina bifida	ORPHA:1120
Trisomy 18	Spina bifida, Microcephaly, Anencephaly, Aplasia/Hypoplasia of the corpus callosum, Holoprosencep...	ORPHA:3380
Lipoyltransferase 1 Deficiency	Hyperglutaminemia, Hyperprolinemia, Increased total bilirubin	OMIM:616299
Sirenomelia	Spina bifida, Sirenomelia	ORPHA:3169
Intellectual Disability-Autism-Speech Apraxia-Craniofacial Dysmorphism Syndrome	Dermal translucency	ORPHA:529965
Combined Osteogenesis Imperfecta And Ehlers-Danlos Syndrome 2	Dermal translucency	OMIM:619120
Ehlers-Danlos Syndrome, Dermatosparaxis Type	Umbilical hernia, Redundant skin, Dermal translucency	OMIM:225410
Fontaine Progeroid Syndrome	Dermal translucency, Atrial septal defect, Bicuspid aortic valve, Redundant skin, Periventricular...	OMIM:612289
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2	Ventricular septal defect, Patent ductus arteriosus, High palate, Pulmonic stenosis, Atrial septa...	OMIM:617506
Pilarowski-Bjornsson Syndrome	Dermal translucency	OMIM:617682
Neu-Laxova Syndrome 2	Decreased fetal movement, Spina bifida, Microcephaly, Polyhydramnios, Lissencephaly, Cerebellar h...	OMIM:616038
Exudative Vitreoretinopathy 2, X-Linked	Retinal detachment, Peripheral retinal avascularization, Subretinal exudate, Intraretinal exudate...	OMIM:305390
Czeizel-Losonci Syndrome	Thickened nuchal skin fold, Spina bifida, Myelomeningocele, Hydrocephalus, Spina bifida occulta	ORPHA:2437
Fetal Akinesia Deformation Sequence 1	Decreased fetal movement, Premature birth, Absent septum pellucidum, Polyhydramnios, Fetal akines...	OMIM:208150
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Hypertyrosinemia, Decreased HDL cholesterol concentration, Abnormal circulating lipid concentrati...	ORPHA:247598
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation	Large placenta, Umbilical hernia, Polyhydramnios	ORPHA:254534
Cholestasis-Lymphedema Syndrome	Conjugated hyperbilirubinemia, Hyperlipidemia	OMIM:214900
Reese Retinal Dysplasia	Remnants of the hyaloid vascular system, Retinal dysplasia	OMIM:266400
Aprosencephaly Syndrome	Aprosencephaly, Anencephaly	OMIM:207770
Neurodevelopmental Disorder With Microcephaly, Seizures, And Neonatal Cholestasis	Increased serum bile acid concentration, Irritability, Hyperbilirubinemia	OMIM:619685
Bile Acid Conjugation Defect 1	Conjugated hyperbilirubinemia	OMIM:619232
Glycogen Storage Disease Due To Phosphoglycerate Kinase 1 Deficiency	Retinal dystrophy, Hyperbilirubinemia	ORPHA:713
Diabetic Embryopathy	Microcephaly, Hydrocephalus, Aplasia/Hypoplasia of the corpus callosum, Spinal dysraphism, Single...	ORPHA:1926
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency	Increased circulating ferritin concentration, Elevated transferrin saturation, Increased serum ir...	ORPHA:766
Polymicrogyria With Or Without Vascular-Type Ehlers-Danlos Syndrome	Polymicrogyria, Pulmonic stenosis, Dermal translucency	OMIM:618343
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 2	Cleft palate, Cutis laxa, Dermal translucency	OMIM:615349
Hypermethioninemia Due To Adenosine Kinase Deficiency	Elevated circulating creatine kinase concentration, Elevated circulating S-adenosyl-L-methionine ...	OMIM:614300
Fountain Syndrome	Spina bifida occulta, Spina bifida	ORPHA:3219
Waardenburg Syndrome Type 1	Meningocele, Spina bifida	ORPHA:894
Exudative Vitreoretinopathy 1	Retinal detachment, Peripheral retinal avascularization, Vitreous floaters, Exudative vitreoretin...	OMIM:133780
Mosaic Trisomy 9	Spina bifida, Microcephaly, Asplenia, Polyhydramnios, Patent ductus arteriosus, Hydrops fetalis, ...	ORPHA:99776
Hijazi-Reis Syndrome	Hyperbilirubinemia	OMIM:301094
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome	Hydrocephalus, Mitral valve prolapse, High palate, Dermal translucency	ORPHA:536467
Vitreoretinal Degeneration, Snowflake Type	Retinal detachment, Snowflake vitreoretinal degeneration, Optically empty vitreous, Retinal dots	OMIM:193230
Meckel Syndrome	Encephalocele, Accessory spleen, Microcephaly, Asplenia, Hydrocephalus, Anencephaly, Lobar holopr...	ORPHA:564
Mitochondrial Dna Depletion Syndrome 16 (Hepatic Type)	Conjugated hyperbilirubinemia, Hyperkalemia, Hypoalbuminemia, Increased total bilirubin	OMIM:618528
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome	Dermal translucency	OMIM:137940
Loeys-Dietz Syndrome 1	Bicuspid aortic valve, Eosinophilic infiltration of the esophagus, Patent ductus arteriosus, Hydr...	OMIM:609192
Neu-Laxova Syndrome	Decreased fetal movement, Cerebral calcification, Absent septum pellucidum, Spina bifida, Abnorma...	ORPHA:2671
Spherocytosis, Type 4	Hyperbilirubinemia	OMIM:612653
Chromosome 17P13.1 Deletion Syndrome	Decreased fetal movement, Diffuse cerebral atrophy, Spina bifida, Microcephaly, Hydrocephalus, Um...	OMIM:613776
Rh-Null, Regulator Type	Unconjugated hyperbilirubinemia	OMIM:268150
Liver Failure, Infantile, Transient	Irritability, Hypoalbuminemia, Hyperbilirubinemia	OMIM:613070
Autosomal Dominant Spastic Paraplegia Type 29	Hyperbilirubinemia	ORPHA:101009
Cousin Syndrome	Hydranencephaly, Hydrocephalus	OMIM:260660
Hemophagocytic Lymphohistiocytosis, Familial, 1	Hyponatremia, Decreased HDL cholesterol concentration, Hypertriglyceridemia, Increased VLDL chole...	OMIM:267700
Elliptocytosis 2	Neonatal hyperbilirubinemia	OMIM:130600
Restrictive Dermopathy	Dextrocardia, Large placenta, Patent ductus arteriosus, Submucous cleft hard palate, Short umbili...	ORPHA:1662
Adenosine Deaminase, Elevated, Hemolytic Anemia Due To	Hyperbilirubinemia	OMIM:301083
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease	Increased circulating ferritin concentration, Hypertriglyceridemia, Hyperbilirubinemia, Elevated ...	ORPHA:158057
Cholestasis, Benign Recurrent Intrahepatic, 2	Conjugated hyperbilirubinemia	OMIM:605479
Barber-Say Syndrome	Redundant skin, Velopharyngeal insufficiency, High palate, Premature skin wrinkling, Dry skin, De...	OMIM:209885
Harderoporphyria	Increased circulating ferritin concentration, Neonatal hyperbilirubinemia	OMIM:618892
Hydrolethalus Syndrome 1	Accessory spleen, Absent septum pellucidum, Abnormal cortical gyration, Polyhydramnios, Anencepha...	OMIM:236680
Infantile Sialic Acid Storage Disease	Conjugated hyperbilirubinemia	OMIM:269920
Loeys-Dietz Syndrome 2	Bicuspid aortic valve, Eosinophilic infiltration of the esophagus, Patent ductus arteriosus, Hydr...	OMIM:610168
Spherocytosis, Type 1	Hyperbilirubinemia	OMIM:182900
Coloboma Of Optic Nerve	Retinal detachment, Optic disc coloboma	OMIM:120430
Spherocytosis, Type 2	Hyperbilirubinemia	OMIM:616649
Autosomal Dominant Cutis Laxa	Redundant neck skin, Redundant skin, Dilatation of the ventricular cavity, Cutis laxa, Small bowe...	ORPHA:90348
Idiopathic Congenital Hypothyroidism	Neonatal hyperbilirubinemia	ORPHA:95717
Vacterl With Hydrocephalus	Polyhydramnios, Spina bifida, Aqueductal stenosis, Hydrocephalus, Single umbilical artery, Intrau...	ORPHA:3412
Bachmann-Bupp Syndrome	Attention deficit hyperactivity disorder, Hyperbilirubinemia	OMIM:619075
Congenital Bile Acid Synthesis Defect Type 2	Conjugated hyperbilirubinemia, Hyperbilirubinemia, Abnormal serum bile acid concentration	ORPHA:79303
Bile Acid Synthesis Defect, Congenital, 4	Decreased serum bile acid concentration, Hyperbilirubinemia	OMIM:214950
Congenital Hypothyroidism Due To Transplacental Passage Of Tsh-Binding Inhibitory Antibodies	Conjugated hyperbilirubinemia, Abnormal circulating thyroglobulin level	ORPHA:95715
Intrahepatic Cholestasis Of Pregnancy	Increased serum bile acid concentration, Hyperbilirubinemia, Depression	ORPHA:69665
Hepatoportal Sclerosis	Cognitive impairment, Hypoalbuminemia, Hyperbilirubinemia	ORPHA:64743
Bile Acid Synthesis Defect, Congenital, 2	Hyperbilirubinemia	OMIM:235555
Car T Cell Therapy-Associated Cytokine Release Syndrome	Elevated circulating creatinine concentration, Confusion, Hyperbilirubinemia	ORPHA:542323
Trisomy 20P	Umbilical hernia, Spina bifida	ORPHA:261318
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1	Microcephaly, Tethered cord, Spinal dysraphism	OMIM:617660
Cholestasis, Progressive Familial Intrahepatic, 6	Conjugated hyperbilirubinemia	OMIM:619484
Anemia, Sideroblastic, 3, Pyridoxine-Refractory	Conjugated hyperbilirubinemia, Increased circulating ferritin concentration, Elevated hepatic iro...	OMIM:616860
Congenital Dyserythropoietic Anemia Type Iii	Increased serum iron, Increased total iron binding capacity, Hyperbilirubinemia	ORPHA:98870
Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency	Hyperbilirubinemia	OMIM:235700
Glycogen Storage Disease Vii	Hyperuricemia, Elevated circulating creatine kinase concentration, Increased total bilirubin	OMIM:232800
Dubin-Johnson Syndrome	Conjugated hyperbilirubinemia	ORPHA:234
Drug-Induced Autoimmune Hemolytic Anemia	Increased total bilirubin	ORPHA:90037
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi	Splenomegaly, Tethered cord, Spinal dysraphism	OMIM:612918
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion	Umbilical hernia, Large placenta, Polyhydramnios, Intrauterine growth retardation	ORPHA:254528
Fibular Hemimelia	Thrombocytopenia, Spina bifida	ORPHA:93323
Distal Xq28 Microduplication Syndrome	Neonatal hyperbilirubinemia, Attention deficit hyperactivity disorder, Depression	ORPHA:293939
Wiedemann-Rautenstrauch Syndrome	Hydrocephalus, Congenital malformation of the left heart, Severe intrauterine growth retardation,...	ORPHA:3455
Cholestasis, Progressive Familial Intrahepatic, 5	Conjugated hyperbilirubinemia, Hyperammonemia, Elevated circulating alpha-fetoprotein concentration	OMIM:617049
Lumbar Syndrome	Myelomeningocele, Spina bifida	ORPHA:83628
Focal Dermal Hypoplasia	Umbilical hernia, Patent ductus arteriosus, Spina bifida	ORPHA:2092
Phakomatosis Pigmentokeratotica	Spina bifida	ORPHA:2874
Congenital Bile Acid Synthesis Defect Type 3	Hyperbilirubinemia	ORPHA:79302
Ring Chromosome 13 Syndrome	Agenesis of corpus callosum, Anencephaly, Microcephaly	ORPHA:96176
Thrombocytopenia-Absent Radius Syndrome	Cerebellar vermis hypoplasia, Eosinophilia, Spina bifida, Thrombocytopenia, Patent ductus arterio...	OMIM:274000
Mosaic Trisomy 16	Premature birth, Large placenta, Patent ductus arteriosus, Single umbilical artery, Intrauterine ...	ORPHA:1708
Hypermanganesemia With Dystonia 1	Hypermanganesemia, Increased total iron binding capacity, Unconjugated hyperbilirubinemia	OMIM:613280
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair	Hyperbilirubinemia	OMIM:609734
Cholestasis, Progressive Familial Intrahepatic, 8	Conjugated hyperbilirubinemia, Hypercholesterolemia, Elevated circulating alpha-fetoprotein conce...	OMIM:619662
Loeys-Dietz Syndrome 3	Ventricular hypertrophy, Bicuspid aortic valve, Eosinophilic infiltration of the esophagus, Paten...	OMIM:613795
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2	Spinal dysraphism	OMIM:603546
Familial Thyroid Dyshormonogenesis	Abnormal circulating thyroglobulin level, Neonatal hyperbilirubinemia	ORPHA:95716
Peroxisome Biogenesis Disorder 12A (Zellweger)	Elevated circulating long chain fatty acid concentration, Hyperbilirubinemia	OMIM:614886
Hemophagocytic Lymphohistiocytosis, Familial, 2	Hyponatremia, Hypertriglyceridemia, Increased circulating ferritin concentration, Irritability, H...	OMIM:603553
Waardenburg Syndrome, Type 1	Myelomeningocele, Spina bifida	OMIM:193500
Fructose-1,6-Bisphosphatase Deficiency	Hyperalaninemia, Irritability, Hyperuricemia, Neonatal hyperbilirubinemia	ORPHA:348
Pagod Syndrome	Encephalocele, Spina bifida, Microcephaly, Abnormality of the spleen, Meningocele	ORPHA:991
Fibromuscular Dysplasia, Multifocal	Hiatus hernia, High palate, Striae distensae, Dermal translucency	OMIM:619329
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum	Tethered cord, Spina bifida, Patent ductus arteriosus, Partial agenesis of the corpus callosum, T...	OMIM:619480
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)	Hypertyrosinemia, Conjugated hyperbilirubinemia, Hypoalbuminemia, Hypermethioninemia, Hyperbiliru...	OMIM:617156
Dehydrated Hereditary Stomatocytosis 2	Hyperbilirubinemia	OMIM:616689
Nail-Patella Syndrome	Spina bifida	OMIM:161200
Fanconi Anemia	Pyridoxine-responsive sideroblastic anemia, Spina bifida, Microcephaly, Patent ductus arteriosus,...	ORPHA:84
Trichohepatoenteric Syndrome 1	Increased mean platelet volume, Polyhydramnios, Splenomegaly, Large placenta, Abnormalities of pl...	OMIM:222470
Wolcott-Rallison Syndrome	Hyponatremia, Hyperammonemia, Hypoalbuminemia, Hyperbilirubinemia	ORPHA:1667
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome	Optic nerve hypoplasia, Spina bifida, Microcephaly, Hypoplasia of the corpus callosum, Truncus ar...	ORPHA:508498
Mixed-Type Autoimmune Hemolytic Anemia	Increased total bilirubin	ORPHA:90036
Osteopetrosis, Autosomal Recessive 5	Optic disc pallor, Optic atrophy, Irritability, Hypocalcemia, Hyperbilirubinemia	OMIM:259720
Cloacal Exstrophy	Myelomeningocele, Spina bifida	ORPHA:93929
Sacral Defect With Anterior Meningocele	Myeloschisis, Tethered cord, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract, Hy...	OMIM:600145
Fanconi-Bickel Syndrome	Hypouricemia, Hypophosphatemia, Hypokalemia, Hypergalactosemia, Increased serum bile acid concent...	OMIM:227810
Ehlers-Danlos Syndrome, Vascular Type	Ecchymosis, Mitral valve prolapse, Anemia, Dermal translucency	OMIM:130050
Abetalipoproteinemia	Decreased HDL cholesterol concentration, Abnormality of retinal pigmentation, Rod-cone dystrophy,...	ORPHA:14
Ulnar Hemimelia	Spinal dysraphism	ORPHA:93320
Cholestasis, Progressive Familial Intrahepatic, 2	Conjugated hyperbilirubinemia	OMIM:601847
Aicardi Syndrome	Cerebellar vermis hypoplasia, Spina bifida, Microcephaly, Partial agenesis of the corpus callosum...	OMIM:304050
Jacobsen Syndrome	Premature birth, Spina bifida, Cerebral atrophy, Intrauterine growth retardation, Pachygyria, Age...	ORPHA:2308
22Q11.2 Deletion Syndrome	Spina bifida, Microcephaly, Polyhydramnios, Splenomegaly, Patent ductus arteriosus, Meningocele, ...	ORPHA:567
Cholestasis, Progressive Familial Intrahepatic, 1	Conjugated hyperbilirubinemia	OMIM:211600
Cutis Laxa, Autosomal Recessive, Type Ib	High palate, Cutis laxa, Dermal translucency	OMIM:614437
Basal Cell Nevus Syndrome 1	Calcification of falx cerebri, Hydrocephalus, Spina bifida	OMIM:109400
Dehydrated Hereditary Stomatocytosis	Hemolytic anemia, Reticulocytosis, Macrocytic anemia, Anemia of inadequate production, Portal vei...	ORPHA:3202
Vater/Vacterl Association	Occipital encephalocele, Tethered cord, Spina bifida, Patent ductus arteriosus, Single umbilical ...	OMIM:192350
Relapsing Fever	Elevated circulating creatinine concentration, Elevated circulating C-reactive protein concentrat...	ORPHA:91547
Bile Acid Synthesis Defect, Congenital, 1	Conjugated hyperbilirubinemia, Hypocholesterolemia	OMIM:607765
Hallermann-Streiff Syndrome	Spina bifida, Microcephaly	OMIM:234100
Graft Versus Host Disease	Irritability, Hyperbilirubinemia	ORPHA:39812
Spastic Paraplegia 29, Autosomal Dominant	Neonatal hyperbilirubinemia	OMIM:609727
Kagami-Ogata Syndrome	Large placenta, Premature birth, Polyhydramnios	ORPHA:254519
Pyruvate Carboxylase Deficiency	Hypoglutaminemia, Increased serum pyruvate, Hyperglutamatemia, Hyperammonemia, Hyperprolinemia, H...	ORPHA:3008
Sickle Cell Anemia	Elevated circulating creatinine concentration, Unconjugated hyperbilirubinemia	ORPHA:232
Pyruvate Kinase Deficiency Of Red Cells	Reduced haptoglobin level, Unconjugated hyperbilirubinemia	OMIM:266200
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Elevated circulating creatine kinase concentration, Elevated circulating long chain fatty acid co...	OMIM:608836
Hereditary Elliptocytosis	Neonatal hyperbilirubinemia, Hyperbilirubinemia	ORPHA:288
Overhydrated Hereditary Stomatocytosis	Hyperbilirubinemia	OMIM:185000
Chronic Bilirubin Encephalopathy	Hypernatremia, Hypoalbuminemia, Neonatal hyperbilirubinemia	ORPHA:529808
Acute Bilirubin Encephalopathy	Hypernatremia, Hypoalbuminemia, Neonatal hyperbilirubinemia	ORPHA:529799
Greenberg Dysplasia	Nonimmune hydrops fetalis, Polyhydramnios, Echogenic fetal bowel, Large placenta, Increased nucha...	OMIM:215140
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)	Elevated circulating alpha-fetoprotein concentration, Hypoalbuminemia, Hyperbilirubinemia	OMIM:251880
Autoimmune Hepatitis	Depression, Increased total bilirubin	ORPHA:2137
Bile Acid Synthesis Defect, Congenital, 3	Hyperbilirubinemia	OMIM:613812
Anemia, Congenital Dyserythropoietic, Type Iv	Unconjugated hyperbilirubinemia, Reduced haptoglobin level, Hyperbilirubinemia	OMIM:613673
Pituitary Hormone Deficiency, Combined, 6	Hyperbilirubinemia	OMIM:613986
Arthrogryposis, Renal Dysfunction, And Cholestasis 2	Conjugated hyperbilirubinemia	OMIM:613404
Restrictive Dermopathy 1	Spontaneous chorioamniotic separation, Decreased fetal movement, Premature birth, Polyhydramnios,...	OMIM:275210
Isolated Thyroid-Stimulating Hormone Deficiency	Depression, Attention deficit hyperactivity disorder, Hypercholesterolemia, Abnormal circulating ...	ORPHA:90674
Growth Retardation, Impaired Intellectual Development, Hypotonia, And Hepatopathy	Conjugated hyperbilirubinemia, Decreased serum zinc, Hypoalbuminemia, Hyperammonemia	OMIM:617093
Neurofibromatosis, Type I	Aqueductal stenosis, Hydrocephalus, Spina bifida	OMIM:162200
Holoprosencephaly	Encephalocele, Microcephaly, Abnormality of the spleen, Hydrocephalus, Spinal cord tumor, Spinal ...	ORPHA:2162
Split Cord Malformation	Tethered cord, Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Meningocele, Hydroc...	ORPHA:573278
Peroxisome Biogenesis Disorder 13A (Zellweger)	Conjugated hyperbilirubinemia, Increased circulating very long-chain fatty acid concentration	OMIM:614887
Wilson Disease	Decreased circulating ceruloplasmin concentration, Hypouricemia, Dementia, Hypoalbuminemia, High ...	OMIM:277900
Koolen-De Vries Syndrome Due To A Point Mutation	Spina bifida, Microcephaly, Hydrocephalus, Fetal pyelectasis, Dural ectasia, Hypoplasia of the co...	ORPHA:363965
17Q21.31 Microdeletion Syndrome	Spina bifida, Microcephaly, Hydrocephalus, Fetal pyelectasis, Dural ectasia, Hypoplasia of the co...	ORPHA:363958
Peroxisome Biogenesis Disorder 5A (Zellweger)	Conjugated hyperbilirubinemia, Optic nerve dysplasia, Optic atrophy, Elevated circulating phytani...	OMIM:614866
Rubinstein-Taybi Syndrome 1	Accessory spleen, Spina bifida, Microcephaly, Polyhydramnios, Patent ductus arteriosus, Hyperinte...	OMIM:180849
Vascular Ehlers-Danlos Syndrome	Abnormal heart valve morphology, Redundant skin, High, narrow palate, Mitral valve prolapse, Exce...	ORPHA:286
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency	Decreased glucose-6-phosphate dehydrogenase level in blood, Unconjugated hyperbilirubinemia	OMIM:300908
Rh Deficiency Syndrome	Reduced haptoglobin level, Hyperbilirubinemia	ORPHA:71275
Glycogen Storage Disease Xii	Reduced haptoglobin level, Elevated circulating creatine kinase concentration, Hyperbilirubinemia	OMIM:611881
Fumarase Deficiency	Optic atrophy, Hyperbilirubinemia	OMIM:606812
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Conjugated hyperbilirubinemia	OMIM:208085
Isolated Posterior Meningocele	Tethered cord, Hydrocephalus, Meningocele, Lipomyelomeningocele, Neural tube defect, Hydromyelia,...	ORPHA:268810
Anemia, Congenital Dyserythropoietic, Type Ia	Hyperbilirubinemia	OMIM:224120
Campomelic Dysplasia	Hydrocephalus, Polyhydramnios, Spina bifida, Spinal dysraphism	OMIM:114290
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome	Vitreous hemorrhage, Retinal hemorrhage, Hyperbilirubinemia	ORPHA:464321
Cystic Echinococcosis	Hyperbilirubinemia	ORPHA:400
Mitchell-Riley Syndrome	Hyperbilirubinemia	OMIM:615710
Lissencephaly Due To Lis1 Mutation	Neonatal hyperbilirubinemia	ORPHA:95232
Cartilage-Hair Hypoplasia	Neutropenia, Anemia, Spinal dysraphism	ORPHA:175
Hereditary Spherocytosis	Hyperbilirubinemia	ORPHA:822
Shiga Toxin-Associated Hemolytic Uremic Syndrome	Hyponatremia, Elevated circulating creatinine concentration, Irritability, Hypokalemia, Unconjuga...	ORPHA:90038
Developmental Delay, Impaired Speech, And Behavioral Abnormalities	Short attention span, Depression, Irritability, Diminished ability to concentrate, Attention defi...	OMIM:619475
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14	Premature birth, Polyhydramnios, Microcephaly, Large placenta, Spinal dysraphism, Hepatosplenomeg...	ORPHA:96334
Hypothyroidism Due To Tsh Receptor Mutations	Increased circulating thyroglobulin level, Neonatal hyperbilirubinemia	ORPHA:90673
Beckwith-Wiedemann Syndrome	Premature birth, Polyhydramnios, Splenomegaly, Large placenta, Subchorionic septal cyst, Umbilica...	ORPHA:116
Mirizzi Syndrome	Hyperbilirubinemia	ORPHA:521219
Lathosterolosis	Abnormal circulating cholesterol concentration, Elevated circulating lathosterol concentration, H...	OMIM:607330
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly	Conjugated hyperbilirubinemia, Retinal degeneration	OMIM:208500
Primary Biliary Cholangitis	Conjugated hyperbilirubinemia, Abnormal circulating lipid concentration, Hypoalbuminemia	ORPHA:186
Stomatin-Deficient Cryohydrocytosis With Neurologic Defects	Conjugated hyperbilirubinemia, Hyperkalemia	OMIM:608885
Parenteral Nutrition-Associated Cholestasis	Conjugated hyperbilirubinemia, Hyperlipidemia, Abnormal circulating fatty-acid concentration	ORPHA:567983
Otopalatodigital Syndrome, Type Ii	Umbilical hernia, Hydrocephalus, Stillbirth, Spina bifida	OMIM:304120
Caroli Syndrome	Conjugated hyperbilirubinemia, Hyperbilirubinemia	ORPHA:480520
Hardikar Syndrome	Pigmentary retinopathy, Irritability, Hyperbilirubinemia	OMIM:301068
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome	Hypocalcemia, Hyperbilirubinemia	ORPHA:163979
Ogden Syndrome	Irritability, Hyperbilirubinemia	OMIM:300855
Senior-Boichis Syndrome	Attention deficit hyperactivity disorder, Increased total bilirubin	ORPHA:84081
Exstrophy-Epispadias Complex	Hydrocephalus, Spina bifida, Microcephaly	ORPHA:322
Fructose Intolerance, Hereditary	Bicarbonaturia, Hyperuricemia, Hyperbilirubinemia, Hypophosphatemia	OMIM:229600
Caroli Disease	Conjugated hyperbilirubinemia, Abnormal circulating alpha-fetoprotein concentration	ORPHA:53035
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome	Hyperbilirubinemia	ORPHA:562639
Pearson Marrow-Pancreas Syndrome	Hyperbilirubinemia	OMIM:557000
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis	Irritability, Unconjugated hyperbilirubinemia	OMIM:618278
Hypothyroidism, Congenital, Nongoitrous, 2	Increased circulating thyroglobulin level, Hyperbilirubinemia	OMIM:218700
Hereditary Cryohydrocytosis With Reduced Stomatin	Conjugated hyperbilirubinemia	ORPHA:168577
Isolated Biliary Atresia	Conjugated hyperbilirubinemia	ORPHA:30391
Cranioectodermal Dysplasia 2	Hyperbilirubinemia	OMIM:613610
Reynolds Syndrome	Calcinosis, Hyperbilirubinemia	OMIM:613471
X-Linked Intellectual Disability, Nascimento Type	Neonatal hyperbilirubinemia	ORPHA:163956
Degcags Syndrome	Hyperbilirubinemia	OMIM:619488
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Hyperbilirubinemia, Progressive neurologic deterioration	OMIM:210710
Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome	Optic disc coloboma, Unconjugated hyperbilirubinemia	OMIM:620186
Rajab Interstitial Lung Disease With Brain Calcifications 1	Hypoalbuminemia, Hypocalcemia, Unconjugated hyperbilirubinemia	OMIM:613658
Congenital Erythropoietic Porphyria	Unconjugated hyperbilirubinemia, Abnormal circulating porphyrin concentration, Reduced haptoglobi...	ORPHA:79277
Congenital Disorder Of Glycosylation, Type Iim	Rod-cone dystrophy, Neonatal hyperbilirubinemia	OMIM:300896
Yellow Fever	Elevated circulating creatinine concentration, Elevated circulating creatine kinase concentration...	ORPHA:99829
Neurooculorenal Syndrome	Conjugated hyperbilirubinemia	OMIM:620305
Biliary, Renal, Neurologic, And Skeletal Syndrome	Conjugated hyperbilirubinemia, Increased circulating ferritin concentration, Elevated circulating...	OMIM:619534
Paroxysmal Nocturnal Hemoglobinuria	Unconjugated hyperbilirubinemia, Reduced haptoglobin level, Decreased serum iron, Increased blood...	ORPHA:447
Johanson-Blizzard Syndrome	Conjugated hyperbilirubinemia, Hypocalcemia, Increased VLDL cholesterol concentration	OMIM:243800
Epilepsy, Familial Adult Myoclonic, 7		OMIM:618075

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rapgef2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rapgef2.

No publications found that use IMPC mice or data for Rapgef2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Rapgef2^{tm1a(EUCOMM)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells
Rapgef2^em1(IMPC)H	Exon Deletion	Mice
Rapgef2^em2(IMPC)H	Exon Deletion	Mice
Rapgef2^{tm1e(EUCOMM)Wtsi}	Targeted, non-conditional allele	ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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