Gene: Lrrc8a

Order

Name leucine rich repeat containing 8A

Synonyms
  • Lrrc8
  • ebo

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:2652847    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Lrrc8a

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Lrrc8a data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Lrrc8atm1.1(KOMP)Vlcg HOM Female Male embryonic day 15.5 0.0
abnormal embryo size Lrrc8atm1.1(KOMP)Vlcg HOM Female Male embryonic day 15.5 0.0
abnormal eye morphology Lrrc8atm1.1(KOMP)Vlcg HET Female postnatal 0.0
abnormal lung morphology Lrrc8atm1.1(KOMP)Vlcg HET Female postnatal 0.0
abnormal seminal vesicle morphology Lrrc8atm1.1(KOMP)Vlcg HET Male postnatal 0.0
anophthalmia Lrrc8atm1.1(KOMP)Vlcg HOM Female Male embryonic day 15.5 0.0
edema Lrrc8atm1.1(KOMP)Vlcg HOM Female Male embryonic day 15.5 0.0
enlarged lung Lrrc8atm1.1(KOMP)Vlcg HET Female postnatal 0.0
prenatal lethality prior to heart atrial septation Lrrc8atm1.1(KOMP)Vlcg HOM Female Male embryonic day 14.5 0.0
preweaning lethality, complete penetrance Lrrc8atm1.1(KOMP)Vlcg HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415) (4/4)
Aorta 4 No (4/4)
Blood 2 No
Bone marrow 2 No (1/2)
Brain 4 No (2/4)
Brainstem 4 No (2/4)
Brown adipose tissue 4 No (4/4)
Cartilage tissue 4 No
Cecum 2 No (12/383) (2/2)
Cerebellum 4 No (2/4)
Cerebral cortex 4 No (2/4)
Chest bone 2 No
Colon 2 No (12/127) (2/2)
Diaphragm 2 No (2/2)
Duodenum 2 No (2/127) (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 4 No (7/415) (4/4)
Eye 4 No (4/4)
Gall bladder 2 No
Gonadal fat pad 2 No (2/2)
Harderian gland 2 No (2/2)
Heart 4 No (2/4)
Hindlimb 2 No
Hippocampus 4 No
Hypothalamus 4 No
Ileum 2 No (14/127) (2/2)
Jejunum 2 No (6/127)
Kidney 4 No (18/584) (4/4)
Large intestine 4 No (10/584) (2/4)
Liver 4 No (1/4)
Lower urinary tract 4 No (2/4)
Lung 4 No (4/4)
Lymph node 4 No
Mammary gland 4 No (1/4)
Mesenteric lymph node 2 No
Mesenteric adipose tissue 2 No (2/2)
Midbrain 2 No (2/2)
Olfactory lobe 4 No (2/4)
Ovary 4 No (1/584) (2/4)
Oviduct 4 No (2/4)
Pancreas 4 No (5/584) (4/4)
Parathyroid gland 2 No (2/2)
Parotid gland 2 No (2/2)
Penis 2 No (1/2)
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No (2/4)
Prostate gland 4 No (12/584) (2/4)
Quadriceps 2 No (2/2)
Sciatic nerve 2 No (1/2)
Skeletal muscle 4 No (2/4)
Skin 4 No (4/4)
Small intestine 4 No (9/584) (2/4)
Spinal cord 4 No (4/4)
Spleen 4 No (2/584) (2/4)
Stomach 4 No (12/584) (4/4)
Stomach pyloric region 2 No
Striatum 4 No
Sublingual gland 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 4 No (2/584) (1/4)
Thymus 4 No (1/4)
Thyroid gland 4 No (15/584) (4/4)
Tongue 2 No (5/127) (2/2)
Trachea 4 No (4/4)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 4 No (2/4)
Vagina 2 No
Vas deferens 2 No (15/388)
Vascular system 4 No (2/4)
Vesicular gland 2 No (1/2)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    limb digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    adipose tissue
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Adult LacZ: LacZ Images Section
    18 Images
  • Gross Morphology Embryo E14.5-E15.5
    3 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Lrrc8atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Lrrc8atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue
Lrrc8atm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene