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Gene: Arhgap32 MGI:2450166

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Rho GTPase activating protein 32
Synonyms:
3426406O18Rik,  GC-GAP,  Grit,  PX-RICS,  p200RhoGAP

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Arhgap32 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Arhgap32 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autism, Susceptibility To, 20
Compulsive behaviors, Impaired social interactions, Attention deficit hyperactivity disorder OMIM:618830
Autism, Susceptibility To, 8
Restrictive behavior, Impaired ability to form peer relationships, Seizure, Abnormal repetitive m... OMIM:607373
Autism
Restrictive behavior, Impaired ability to form peer relationships, Seizure, Abnormal repetitive m... OMIM:209850
Chromosome 15Q11-Q13 Duplication Syndrome
Restrictive behavior, Bilateral tonic-clonic seizure, Impaired ability to form peer relationships... OMIM:608636
Asperger Syndrome, Susceptibility To, 1
Restrictive behavior, Abnormal repetitive mannerisms, Impaired ability to form peer relationships... OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Restrictive behavior, Abnormal repetitive mannerisms, Impaired ability to form peer relationships... OMIM:608631
Intellectual Developmental Disorder, Autosomal Recessive 66
Gait ataxia, Aggressive behavior, Attention deficit hyperactivity disorder, Shyness OMIM:618221
Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures
Dystonia, Ataxia, Focal motor status epilepticus, Aggressive behavior, Focal-onset seizure, Chore... OMIM:619150
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Seizure, Hyperactivity, Abnormal social behavior ORPHA:436151
Childhood Disintegrative Disorder
Social and occupational deterioration, Seizure, Dementia, Abnormal emotion, Progressive language ... ORPHA:168782
Neurodevelopmental Disorder With Hypotonia And Impaired Expressive Language And With Or Without Seizures
Bilateral tonic-clonic seizure, Aggressive behavior, Agitation, Status epilepticus, Emotional lab... OMIM:617171
Intellectual Developmental Disorder With Autism And Speech Delay
Abnormal repetitive mannerisms, Impaired social interactions OMIM:606053
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Bilateral tonic-clonic seizure, Impulsivity, Aggressive behavior, Abnormal eating ... ORPHA:101039
Hereditary Geniospasm
Abnormal social behavior, Chin myoclonus, Intention tremor ORPHA:53372
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Ataxia, Tremor, Chorea, Depression, Inappropriate behavior, Myoclonus, Cognitive impairment, Dyst... ORPHA:401901
Intellectual Developmental Disorder, Autosomal Dominant 50, With Behavioral Abnormalities
Seizure, Abnormal repetitive mannerisms, Attention deficit hyperactivity disorder OMIM:617787
Behavioral Variant Of Frontotemporal Dementia
Restrictive behavior, Collectionism, Restlessness, Bilateral tonic-clonic seizure, Aggressive beh... ORPHA:275864
Intellectual Developmental Disorder, Autosomal Recessive 6
Torticollis, Postural tremor, Kinetic tremor, Myoclonus, Impaired social interactions, Atonic sei... OMIM:611092
Pick Disease Of Brain
Frontotemporal dementia, Abnormal repetitive mannerisms, Irritability, Disinhibition, Inappropria... OMIM:172700
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Restlessness, Aggressive behavior, Frontotemporal dementia, Inappropriate behavior, Disinhibition... OMIM:600795
Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive
Self-injurious behavior, Seizure, Impaired social interactions, Dystonia, Abnormal repetitive man... OMIM:617820
Autism, Susceptibility To, X-Linked 3
Restrictive behavior, Seizure, Abnormal repetitive mannerisms, Inflexible adherence to routines OMIM:300496
Autism, Susceptibility To, X-Linked 1
Restrictive behavior, Seizure, Abnormal repetitive mannerisms, Inflexible adherence to routines OMIM:300425
Foxg1 Syndrome
Dystonia, Bilateral tonic-clonic seizure, Infantile spasms, Focal-onset seizure, Bruxism, Choreoa... ORPHA:561854
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Generalized-onset seizure, Ataxia, Bilateral tonic-clonic seizure with focal onset... OMIM:610042
Neurodevelopmental Disorder With Nonspecific Brain Abnormalities And With Or Without Seizures
Seizure, Ataxia, Abnormal repetitive mannerisms, Attention deficit hyperactivity disorder OMIM:618709
N-Acetylaspartate Deficiency
Short attention span, Seizure, Truncal ataxia, Abnormal repetitive mannerisms, Self-mutilation OMIM:614063
Hsd10 Disease
Short attention span, Ataxia, Tremor, Choreoathetosis, Seizure, Myoclonus, Dysphagia, Abnormal so... ORPHA:391417
Primary Dystonia, Dyt13 Type
Torticollis, Generalized dystonia, Postural tremor, Dystonia, Torsion dystonia, Focal dystonia, L... ORPHA:98807
Autism, Susceptibility To, 3
Restrictive behavior, Impaired ability to form peer relationships, Seizure, Abnormal repetitive m... OMIM:608049
Intellectual Developmental Disorder, X-Linked 72
Seizure, Hyperactivity, Abnormal repetitive mannerisms OMIM:300271
Neurodevelopmental Disorder With Epilepsy, Cataracts, Feeding Difficulties, And Delayed Brain Myelination
Infantile spasms, Tonic seizure, Focal-onset seizure, Irritability, Seizure, Abnormal repetitive ... OMIM:617393
Early-Onset Autosomal Dominant Alzheimer Disease
Ataxia, Confusion, Seizure, Dementia, Agitation, Semantic dementia, Disinhibition, Myoclonus, Mem... ORPHA:1020
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Brain Atrophy
Bilateral tonic-clonic seizure, Hand tremor, Gait ataxia, Dysphagia, Recurrent hand flapping, Abn... OMIM:617862
Severe Intellectual Disability-Progressive Postnatal Microcephaly-Midline Stereotypic Hand Movements Syndrome
Self-injurious behavior, Seizure, Stereotypical hand wringing, Impaired social interactions ORPHA:397933
Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Dominant
Epileptic spasm, Dystonia, Oculogyric crisis, Chorea, Myoclonic seizure, Self-injurious behavior,... OMIM:614254
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Hyperactivity, Tremor, Self-injurious behavior, Seizure, Bruxism, Abnormal repetitive mannerisms,... OMIM:618718
Neurodevelopmental Disorder With Language Impairment And Behavioral Abnormalities
Bilateral tonic-clonic seizure, Tonic seizure, Clonic seizure, Focal-onset seizure, Chorea, Gait ... OMIM:618917
Hyperprolinemia, Type I
Hyperactivity, Ataxia, Aggressive behavior, Seizure, Status epilepticus, Abnormal repetitive mann... OMIM:239500
Developmental And Epileptic Encephalopathy 107
Clonic seizure, Seizure, Abnormal repetitive mannerisms, Tonic seizure OMIM:620033
Intellectual Developmental Disorder, Autosomal Recessive 58
Aggressive behavior, Pica, Choreoathetosis, Self-injurious behavior, Abnormal repetitive mannerisms OMIM:617270
Developmental And Epileptic Encephalopathy 6B
Epileptic spasm, Bilateral tonic-clonic seizure, Ataxia, Tonic seizure, Focal hemiclonic seizure,... OMIM:619317
Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures
Short attention span, Epileptic spasm, Bilateral tonic-clonic seizure, Ataxia, Impulsivity, Aggre... OMIM:619580
Atypical Rett Syndrome
Restrictive behavior, Infantile spasms, Impaired pain sensation, Tremor, Tongue thrusting, Gait a... ORPHA:3095
11Q22.2Q22.3 Microdeletion Syndrome
Short attention span, Seizure, Compulsive behaviors, Attention deficit hyperactivity disorder, Ab... ORPHA:444002
Childhood Absence Epilepsy
Bilateral tonic-clonic seizure, Typical absence seizure, Depression, Punding, Attention deficit h... ORPHA:64280
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia
Frontotemporal dementia, Disinhibition, Dysphagia, Emotional lability, Abnormal repetitive manner... OMIM:612069
Parkinsonism-Dystonia 3, Childhood-Onset
Dystonia, Ataxia, Aggressive behavior, Tremor, Chorea, Depression, Impaired social interactions, ... OMIM:619738
Smith-Magenis syndrome
Hyperactivity, Abnormal repetitive mannerisms, Self-mutilation DECIPHER:8
Syngap1-Related Developmental And Epileptic Encephalopathy
Generalized-onset seizure, Ataxia, Abnormal eating behavior, Tremor, Eating-induced seizure, Impa... ORPHA:544254
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders
Seizure, Abnormal repetitive mannerisms, Attention deficit hyperactivity disorder OMIM:620065
Neurodevelopmental Disorder With Or Without Variable Movement Or Behavioral Abnormalities
Resting tremor, Bilateral tonic-clonic seizure, Ataxia, Chorea, Nocturnal seizures, Myoclonus, At... OMIM:619725
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Short attention span, Hyperactivity, Shyness, Aggressive behavior, Depression, Irritability, Self... ORPHA:449291
Developmental And Epileptic Encephalopathy 58
Seizure, Abnormal repetitive mannerisms, Status epilepticus OMIM:617830
Late Infantile Neuronal Ceroid Lipofuscinosis
Hyperactivity, Bilateral tonic-clonic seizure, Generalized myoclonic seizure, Atonic seizure, Agg... ORPHA:168491
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Hyperactivity, Aggressive behavior, Tremor, Seizure, Abnormal repetitive mannerisms OMIM:619470
Developmental And Epileptic Encephalopathy 67
Bilateral tonic-clonic seizure, Tonic seizure, Focal hemiclonic seizure, Generalized non-motor (a... OMIM:618141
Developmental And Epileptic Encephalopathy 30
Generalized myoclonic seizure, Seizure, Abnormal repetitive mannerisms, Bilateral tonic-clonic se... OMIM:616341
Severe Intellectual Disability And Progressive Spastic Paraplegia
Seizure, Dystonia, Abnormal repetitive mannerisms, Shyness ORPHA:280763
Bilateral Generalized Polymicrogyria
Generalized-onset seizure, Bilateral tonic-clonic seizure, Oculogyric crisis, Atonic seizure, Ora... ORPHA:208447
Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features
Aggressive behavior, Self-injurious behavior, Compulsive behaviors, Attention deficit hyperactivi... OMIM:613670
Christianson Syndrome
Generalized-onset seizure, Dystonia, Truncal ataxia, Gait ataxia, Inappropriate laughter, Dysphag... ORPHA:85278
Cortical Dysplasia, Complex, With Other Brain Malformations 2
Self-injurious behavior, Seizure, Abnormal repetitive mannerisms, Clonic seizure OMIM:615282
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Paroxysmal dystonia, Bilateral tonic-clonic seizure, Focal hyperkinetic seizure, Depression, Atte... ORPHA:98784
Kleine-Levin Syndrome
Confusion, Abnormal eating behavior, Repetitive compulsive behavior, Hypersexuality, Sweet cravin... ORPHA:33543
Autism, Susceptibility To, X-Linked 2
Restrictive behavior, Seizure, Abnormal repetitive mannerisms, Inflexible adherence to routines OMIM:300495
Intellectual Developmental Disorder With Autistic Features And Language Delay, With Or Without Seizures
Spastic ataxia, Seizure, Abnormal repetitive mannerisms, Attention deficit hyperactivity disorder OMIM:618906
Lamb-Shaffer Syndrome
Hyperactivity, Ataxia, Seizure, Abnormal temper tantrums, Abnormal social behavior, Abnormal repe... ORPHA:530983
Intellectual Developmental Disorder, Autosomal Dominant 7
Hyperactivity, Ataxia, Seizure, Inappropriate laughter, Febrile seizure (within the age range of ... OMIM:614104
Juvenile Neuronal Ceroid Lipofuscinosis
Bilateral tonic-clonic seizure, Depression, Seizure, Dementia, Progressive language deterioration... ORPHA:79264
2Q23.1 Microdeletion Syndrome
Hyperactivity, Ataxia, Abnormal repetitive mannerisms, Self-injurious behavior, Seizure, Polyphag... ORPHA:228402
Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities
Bilateral tonic-clonic seizure with generalized onset, Ataxia, Tremor, Focal-onset seizure, Myocl... OMIM:619092
Intellectual Developmental Disorder, Autosomal Dominant 45
Hyperactivity, Bilateral tonic-clonic seizure, Chorea, Generalized non-motor (absence) seizure, M... OMIM:617600
Lopes-Maciel-Rodan Syndrome
Dystonia, Tremor, Bruxism, Seizure, Agitation, Focal impaired awareness seizure, Dysphagia, Abnor... OMIM:617435
Neurodevelopmental Disorder With Language Delay And Behavioral Abnormalities, With Or Without Seizures
Hyperactivity, Bilateral tonic-clonic seizure, Aggressive behavior, Seizure, Status epilepticus, ... OMIM:620292
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Ataxia, Confusion, Seizure, Agitation, Cognitive impairment, Emotional lability, Abnormal repetit... ORPHA:927
Baker-Gordon Syndrome
Ataxia, Choreoathetosis, Self-injurious behavior, Dystonia, Abnormal repetitive mannerisms OMIM:618218
Xq28 (MECP2) duplication
Gait ataxia, Depression, Seizure, Dysphagia, Abnormal repetitive mannerisms DECIPHER:45
Neurodevelopmental Disorder With Poor Growth And Behavioral Abnormalities
Short attention span, Hyperactivity, Aggressive behavior, Dysphoria, Depression, Seizure, Attenti... OMIM:620242
Rett Syndrome, Congenital Variant
Dystonia, Chorea, Tongue thrusting, Irritability, Seizure, Athetosis, Impaired social interaction... OMIM:613454
Metachromatic Leukodystrophy, Adult Form
Short attention span, Chorea, Progressive psychomotor deterioration, Emotional lability, Depressi... ORPHA:309271
Intellectual Developmental Disorder, X-Linked 98
Hyperactivity, Bilateral tonic-clonic seizure, Ataxia, Atonic seizure, Aggressive behavior, Tonic... OMIM:300912
Metachromatic Leukodystrophy, Juvenile Form
Short attention span, Progressive psychomotor deterioration, Seizure, Progressive gait ataxia, Dy... ORPHA:309263
Chromosome 3Q29 Deletion Syndrome
Gait ataxia, Hyperactivity, Abnormal repetitive mannerisms, Aggressive behavior OMIM:609425
Pontocerebellar Hypoplasia, Type 11
Ataxia, Limb ataxia, Self-injurious behavior, Seizure, Attention deficit hyperactivity disorder, ... OMIM:617695
Brunet-Wagner Neurodevelopmental Syndrome
Self-injurious behavior, Abnormal repetitive mannerisms, Myoclonic seizure OMIM:619690
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Short attention span, Hyperactivity, Ataxia, Abnormal eating behavior, Tremor, Tongue thrusting, ... ORPHA:98794
Obesity, Hyperphagia, And Developmental Delay
Abnormal repetitive mannerisms, Seizure, Polyphagia, Generalized non-motor (absence) seizure OMIM:613886
Young-Onset Parkinson Disease
Short attention span, Restless legs, Dystonia, Impulsivity, Tremor, Depression, Frontal lobe deme... ORPHA:2828
Chromosome 15Q11.2 Deletion Syndrome
Ataxia, Seizure, Diminished ability to concentrate, Compulsive behaviors, Impaired social interac... OMIM:615656
Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type
Pain insensitivity, Ataxia, Tonic seizure, Repetitive compulsive behavior, Chorea, Generalized no... OMIM:300260
Galloway-Mowat Syndrome 6
Seizure, Abnormal repetitive mannerisms, Paroxysmal bursts of laughter OMIM:618347
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
Bilateral tonic-clonic seizure, Tremor, Depression, Seizure, Abnormal repetitive mannerisms, Self... ORPHA:457240
Developmental And Epileptic Encephalopathy 66
Bilateral tonic-clonic seizure, Bilateral tonic-clonic seizure with focal onset, Tonic seizure, C... OMIM:618067
Intellectual Developmental Disorder, Autosomal Dominant 63, With Macrocephaly
Pain insensitivity, Aggressive behavior, Seizure, Attention deficit hyperactivity disorder, Obses... OMIM:618825
Choreoacanthocytosis
Chorea, Oromandibular dystonia, Compulsive behaviors, Limb dystonia, Laryngeal dystonia, Impaired... ORPHA:2388
Autism Spectrum Disorder Due To Auts2 Deficiency
Hyperactivity, Repetitive compulsive behavior, Seizure, Compulsive behaviors, Attention deficit h... ORPHA:352490
Focal Segmental Glomerulosclerosis And Neurodevelopmental Syndrome
Bilateral tonic-clonic seizure, Bilateral tonic-clonic seizure with focal onset, Infantile spasms... OMIM:619428
Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Short attention span, Hyperactivity, Aggressive behavior, Tremor, Attention deficit hyperactivity... OMIM:618342
Shukla-Vernon Syndrome
Impulsivity, Aggressive behavior, Seizure, Attention deficit hyperactivity disorder, Abnormal rep... OMIM:301029
Oromandibular Dystonia
Torticollis, Generalized dystonia, Bruxism, Dysphagia, Depression, Blepharospasm, Limb dystonia, ... ORPHA:93958
Intellectual Developmental Disorder, Autosomal Recessive 41
Generalized-onset seizure, Bilateral tonic-clonic seizure, Generalized non-motor (absence) seizur... OMIM:615637
48,Xxyy Syndrome
Ataxia, Tremor, Depression, Seizure, Attention deficit hyperactivity disorder, Abnormal repetitiv... ORPHA:10
Proximal 16P11.2 Microdeletion Syndrome
Dystonia, Choreoathetosis, Seizure, Impaired social interactions, Attention deficit hyperactivity... ORPHA:261197
Niemann-Pick Disease Type C
Generalized-onset seizure, Progressive neurologic deterioration, Tremor, Chorea, Progressive gait... ORPHA:646
Metachromatic Leukodystrophy, Late Infantile Form
Gait ataxia, Seizure, Progressive gait ataxia, Dystonia, Emotional lability, Abnormal social beha... ORPHA:309256
Developmental And Epileptic Encephalopathy 64
Paroxysmal dystonia, Dystonia, Chorea, Self-injurious behavior, Seizure, Status epilepticus, Brux... OMIM:618004
Nmda Receptor Encephalitis
Short attention span, Generalized-onset seizure, Confusion, Oculogyric crisis, Hypersexuality, Fo... ORPHA:217253
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Infantile spasms, Atonic seizure, Generalized non-motor (absence) seizure, Focal impaired awarene... ORPHA:411986
Cerebral Creatine Deficiency Syndrome 1
Dystonia, Aggressive behavior, Seizure, Impaired social interactions, Attention deficit hyperacti... OMIM:300352
Chromosome 2Q37 Deletion Syndrome
Hyperactivity, Pain insensitivity, Aggressive behavior, Self-injurious behavior, Seizure, Skin-pi... OMIM:600430
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Ataxia, Aggressive behavior, Dysmetria, Positive Romberg sign, Nonprogressive cerebellar ataxia, ... ORPHA:314647
Aromatic L-Amino Acid Decarboxylase Deficiency
Torticollis, Exaggerated startle response, Oculogyric crisis, Tongue thrusting, Limb tremor, Chor... OMIM:608643
Developmental Delay, Language Impairment, And Ocular Abnormalities
Hyperactivity, Impulsivity, Aggressive behavior, Attention deficit hyperactivity disorder, Freque... OMIM:620141
Smith-Magenis Syndrome
Hyperactivity, Impaired pain sensation, Self hugging, Head-banging, Seizure, Onychotillomania, Ab... OMIM:182290
Developmental And Speech Delay Due To Sox5 Deficiency
Aggressive behavior, Self-injurious behavior, Seizure, Attention deficit hyperactivity disorder, ... ORPHA:313892
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Spastic ataxia, Short attention span, Torticollis, Focal-onset seizure, Delayed early-childhood s... ORPHA:300570
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity, Abnormal repetitive mannerisms, Aggressive behavior OMIM:615541
Blepharophimosis-Impaired Intellectual Development Syndrome
Seizure, Low frustration tolerance, Attention deficit hyperactivity disorder, Abnormal repetitive... OMIM:619293
Short Stature, Developmental Delay, And Congenital Heart Defects
Self-injurious behavior, Compulsive behaviors, Abnormal repetitive mannerisms, Attention deficit ... OMIM:617044
Intellectual Developmental Disorder, Autosomal Dominant 38
Ataxia, Infantile spasms, Aggressive behavior, Hair-pulling, Self-injurious behavior, Bruxism, Ab... OMIM:616393
Houge-Janssens Syndrome 3
Bilateral tonic-clonic seizure, Bilateral tonic-clonic seizure with focal onset, Focal-onset seiz... OMIM:618354
Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type
Ataxia, Aggressive behavior, Self-injurious behavior, Seizure, Compulsive behaviors, Attention de... OMIM:300986
Cri-Du-Chat Syndrome
Short attention span, Hyperactivity, Aggressive behavior, Abnormal repetitive mannerisms, Self-mu... OMIM:123450
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Irritability, Hyperactivity, Abnormal repetitive mannerisms, Aggressive behavior ORPHA:391307
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Hyperactivity, Gait ataxia, Seizure, Low frustration tolerance, Abnormal repetitive mannerisms, S... OMIM:300486
Coffin-Siris Syndrome 6
Abnormal repetitive mannerisms, Seizure, Tics, Attention deficit hyperactivity disorder OMIM:617808
Neurodevelopmental Disorder With Hypotonia, Impaired Language, And Dysmorphic Features
Gait ataxia, Impaired pain sensation, Abnormal repetitive mannerisms, Overfriendliness OMIM:616579
48,Xxxy Syndrome
Tremor, Irritability, Seizure, Attention deficit hyperactivity disorder, Abnormal social behavior... ORPHA:96263
Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly
Pain insensitivity, Aggressive behavior, Tremor, Self-injurious behavior, Seizure, Compulsive beh... OMIM:617061
Den Hoed-De Boer-Voisin Syndrome
Short attention span, Ataxia, Generalized clonic seizure, Tremor, Focal-onset seizure, Focal myoc... OMIM:619229
Intellectual Developmental Disorder, Autosomal Recessive 71
Seizure, Abnormal repetitive mannerisms, Attention deficit hyperactivity disorder OMIM:618504
Ritscher-Schinzel Syndrome 4
Bilateral tonic-clonic seizure, Ataxia, Impulsivity, Aggressive behavior, Focal-onset seizure, Ch... OMIM:619435
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hyperactivity, Bilateral tonic-clonic seizure, Infantile spasms, Hair-pulling, Irritability, Myoc... ORPHA:447997
Intellectual Developmental Disorder, Autosomal Dominant 52
Hyperactivity, Pica, Irritability, Seizure, Obsessive-compulsive trait, Abnormal repetitive manne... OMIM:617796
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Repetitive compulsive behavior, Frontotemporal dementia, Hypersexuality, Agitation, Progressive l... OMIM:607485
Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, And Decreased Cortical White Matter
Dystonia, Generalized-onset seizure, Abnormal repetitive mannerisms, Gait ataxia OMIM:617807
Dentici-Novelli Neurodevelopmental Syndrome
Epileptic spasm, Abnormal repetitive mannerisms, Bilateral tonic-clonic seizure, Myoclonic seizure OMIM:619877
Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities
Hyperactivity, Ataxia, Aggressive behavior, Seizure, Compulsive behaviors, Abnormal repetitive ma... OMIM:618430
4Q21 Microdeletion Syndrome
Tremor, Self-injurious behavior, Seizure, Abnormal repetitive mannerisms ORPHA:238750
Radio-Tartaglia Syndrome
Ataxia, Impulsivity, Aggressive behavior, Tremor, Seizure, Attention deficit hyperactivity disord... OMIM:619312
X-Linked Intellectual Disability, Cantagrel Type
Seizure, Abnormal repetitive mannerisms ORPHA:85277
Inverted Duplicated Chromosome 15 Syndrome
Hyperactivity, Aggressive behavior, Self-biting, Seizure, Abnormal repetitive mannerisms ORPHA:3306
Alazami Syndrome
Abnormal eating behavior, Seizure, Abnormal repetitive mannerisms, Self-mutilation, Stereotypical... ORPHA:319671
Potocki-Lupski Syndrome
Seizure, Hyperactivity, Abnormal repetitive mannerisms, Oral-pharyngeal dysphagia OMIM:610883
Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language
Seizure, Abnormal repetitive mannerisms OMIM:613443
Phelan-Mcdermid Syndrome
Aggressive behavior, Impaired pain sensation, Tongue thrusting, Seizure, Impaired social interact... OMIM:606232
Snijders Blok-Campeau Syndrome
Abnormal repetitive mannerisms, Infantile spasms, Attention deficit hyperactivity disorder, Myocl... OMIM:618205
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
Aggressive behavior, Tremor, Gait ataxia, Seizure, Compulsive behaviors, Attention deficit hypera... ORPHA:476126
White-Sutton Syndrome
Hyperactivity, Aggressive behavior, Hypoglycemic seizures, Irritability, Self-injurious behavior,... OMIM:616364
Neurodevelopmental Disorder With Dysmorphic Features, Spasticity, And Brain Abnormalities
Generalized non-motor (absence) seizure, Abnormal repetitive mannerisms, Inappropriate laughter, ... OMIM:615802
Niemann-Pick Disease, Type C2
Dystonia, Ataxia, Seizure, Dementia, Dysphagia, Abnormal repetitive mannerisms OMIM:607625
5Q14.3 Microdeletion Syndrome
Seizure, Abnormal repetitive mannerisms ORPHA:228384
Neurodevelopmental Disorder With Cardiomyopathy, Spasticity, And Brain Abnormalities
Aggressive behavior, Dysmetria, Attention deficit hyperactivity disorder, Truncal ataxia, Abnorma... OMIM:619121
Hijazi-Reis Syndrome
Seizure, Abnormal repetitive mannerisms OMIM:301094
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Clonic seizure, Tics, Compulsive behaviors, Abnormal repetitive mannerisms, Intention tremor, Res... OMIM:619475
3P25.3 Microdeletion Syndrome
Bilateral tonic-clonic seizure, Ataxia, Generalized non-motor (absence) seizure, Attention defici... ORPHA:435638
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Nail-biting, Pain insensitivity, Bilateral tonic-clonic seizure, Aggressive behavior, Hair-pullin... OMIM:620330
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome
Ataxia, Aggressive behavior, Seizure, Low frustration tolerance, Abnormal temper tantrums, Abnorm... ORPHA:457279
22Q11.2 Duplication Syndrome
Seizure, Compulsive behaviors, Abnormal repetitive mannerisms, Attention deficit hyperactivity di... ORPHA:1727
Neurodevelopmental Disorder With Microcephaly, Seizures, And Cortical Atrophy
Focal-onset seizure, Seizure, Status epilepticus, Dysphagia, Abnormal repetitive mannerisms OMIM:617802
Tuberous Sclerosis Complex
Hyperactivity, Epileptic spasm, Impulsivity, Aggressive behavior, Infantile spasms, Repetitive co... ORPHA:805
Developmental And Epileptic Encephalopathy 100
Bilateral tonic-clonic seizure, Infantile spasms, Tonic seizure, Focal-onset seizure, Typical abs... OMIM:619777
Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities
Head-banging, Seizure, Attention deficit hyperactivity disorder, Frequent temper tantrums, Abnorm... OMIM:619103
Smith-Magenis Syndrome
Impaired pain sensation, Self-injurious behavior, Seizure, Attention deficit hyperactivity disord... ORPHA:819
Neurodevelopmental Disorder With Dysmorphic Facies And Skeletal And Brain Abnormalities
Seizure, Febrile seizure (within the age range of 3 months to 6 years), Abnormal repetitive manne... OMIM:620073
Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome
Myoclonic seizure, Abnormal repetitive mannerisms, Infantile spasms, Dysphagia ORPHA:572013
Intellectual Developmental Disorder, Autosomal Dominant 48
Seizure, Hyperactivity, Abnormal repetitive mannerisms OMIM:617751
Prader-Willi Syndrome Due To Translocation
Head-banging, Seizure, Compulsive behaviors, Impaired social interactions, Attention deficit hype... ORPHA:177907
Microcephaly-Intellectual Disability-Sensorineural Hearing Loss-Epilepsy-Abnormal Muscle Tone Syndrome
Bilateral tonic-clonic seizure, Infantile spasms, Generalized non-motor (absence) seizure, Self-i... ORPHA:457351
Intellectual Developmental Disorder, Autosomal Dominant 34
Abnormal repetitive mannerisms, Bilateral tonic-clonic seizure, Bruxism OMIM:616351
Chromosome 5P13 Duplication Syndrome
Self-injurious behavior, Seizure, Abnormal repetitive mannerisms, Compulsive behaviors OMIM:613174
Macrocephaly-Developmental Delay Syndrome
Self-injurious behavior, Seizure, Abnormal repetitive mannerisms ORPHA:397612
Fg Syndrome Type 1
Compulsive behaviors, Seizure, Abnormal social behavior, Attention deficit hyperactivity disorder ORPHA:93932
Coffin-Siris Syndrome 7
Abnormal repetitive mannerisms, Hyperactivity, Severe temper tantrums, Compulsive behaviors OMIM:618027
Developmental And Epileptic Encephalopathy 2
Generalized-onset seizure, Multifocal seizures, Infantile spasms, Seizure, Myoclonus, Generalized... OMIM:300672
Van Esch-O'Driscoll Syndrome
Impulsivity, Shyness, Seizure, Attention deficit hyperactivity disorder, Abnormal repetitive mann... OMIM:301030
Wiedemann-Steiner Syndrome
Psychomotor deterioration, Short attention span, Hyperactivity, Aggressive behavior, Seizure, Low... ORPHA:319182
Rett Syndrome
Seizure, Agitation, Dystonia, Abnormal repetitive mannerisms, Stereotypical hand wringing ORPHA:778
Trichotillomania
Hair-pulling, Compulsive behaviors OMIM:613229
Microcephaly-Corpus Callosum And Cerebellar Vermis Hypoplasia-Facial Dysmorphism-Intellectual Disability Syndrom
Seizure, Abnormal repetitive mannerisms ORPHA:500159
Intellectual Disability-Autism-Speech Apraxia-Craniofacial Dysmorphism Syndrome
Seizure, Abnormal repetitive mannerisms ORPHA:529965
Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome
Dystonia, Bilateral tonic-clonic seizure, Ataxia, Dysphagia, Febrile seizure (within the age rang... ORPHA:496641
Dihydropyrimidine Dehydrogenase Deficiency
Focal motor seizure, Irritability, Seizure, Febrile seizure (within the age range of 3 months to ... ORPHA:1675
Pilarowski-Bjornsson Syndrome
Seizure, Abnormal repetitive mannerisms OMIM:617682
7Q11.23 Microduplication Syndrome
Collectionism, Hyperactivity, Aggressive behavior, Polyphagia, Dysmetria, Self-injurious behavior... ORPHA:96121
Neurodevelopmental, Jaw, Eye, And Digital Syndrome
Self-injurious behavior, Abnormal repetitive mannerisms, Impulsivity, Aggressive behavior OMIM:618914
2Q37 Microdeletion Syndrome
Seizure, Compulsive behaviors, Abnormal repetitive mannerisms, Attention deficit hyperactivity di... ORPHA:1001
Developmental Delay With Or Without Intellectual Impairment Or Behavioral Abnormalities
Short attention span, Head-banging, Self-injurious behavior, Seizure, Attention deficit hyperacti... OMIM:619575
Infantile Hypotonia-Oculomotor Anomalies-Hyperkinetic Movements-Developmental Delay Syndrome
Ataxia, Repetitive compulsive behavior, Chorea, Self-biting, Choreoathetosis, Dystonia, Abnormal ... ORPHA:522077
Helsmoortel-Van Der Aa Syndrome
Hyperactivity, Tonic seizure, Abnormal repetitive mannerisms, Typical absence seizure, Bruxism, D... OMIM:615873
Transketolase Deficiency
Self-injurious behavior, Compulsive behaviors, Abnormal repetitive mannerisms, Attention deficit ... ORPHA:488618
Megalocornea-Intellectual Disability Syndrome
Seizure, Abnormal repetitive mannerisms, Ataxia ORPHA:2479
Foxg1 Syndrome Due To 14Q12 Microdeletion
Seizure, Abnormal repetitive mannerisms ORPHA:261144
Kleefstra Syndrome 1
Seizure, Abnormal repetitive mannerisms, Compulsive behaviors, Aggressive behavior OMIM:610253
White-Sutton Syndrome
Hyperactivity, Aggressive behavior, Self-injurious behavior, Seizure, Focal impaired awareness se... ORPHA:468678
Congenital Disorder Of Glycosylation, Type Iia
Aggressive behavior, Seizure, Abnormal repetitive mannerisms, Self-mutilation, Stereotypical hand... OMIM:212066
Neurodevelopmental Disorder With Dysmorphic Facies, Impaired Speech, And Hypotonia
Impaired pain sensation, Seizure, Attention deficit hyperactivity disorder, Abnormal repetitive m... OMIM:619005
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Social and occup... ORPHA:353281
Mend Syndrome
Seizure, Hyperactivity, Abnormal social behavior, Aggressive behavior ORPHA:401973
Cerebellar Dysfunction With Variable Cognitive And Behavioral Abnormalities
Hyperactivity, Bilateral tonic-clonic seizure, Ataxia, Aggressive behavior, Generalized myoclonic... OMIM:614756
Joubert Syndrome 6
Abnormal repetitive mannerisms, Ataxia OMIM:610688
Kleefstra Syndrome
Aggressive behavior, Self-injurious behavior, Seizure, Abnormal repetitive mannerisms, Self-mutil... ORPHA:261494
Pitt-Hopkins Syndrome
Self-injurious behavior, Seizure, Abnormal repetitive mannerisms, Gait ataxia OMIM:610954
Cystinosis
Polydipsia, Abnormal repetitive mannerisms ORPHA:213
Mucopolysaccharidosis Type 2
Short attention span, Hyperactivity, Progressive neurologic deterioration, Aggressive behavior, I... ORPHA:580
Bainbridge-Ropers Syndrome
Self-injurious behavior, Recurrent hand flapping, Abnormal repetitive mannerisms, Seizure OMIM:615485
Rauch-Steindl Syndrome
Hyperactivity, Abnormal repetitive mannerisms, Aggressive behavior OMIM:619695
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies
Short attention span, Multifocal seizures, Aggressive behavior, Seizure, Abnormal repetitive mann... OMIM:301066
Hypotonia, Ataxia, And Delayed Development Syndrome
Pain insensitivity, Ataxia, Truncal ataxia, Dysmetria, Gait ataxia, Seizure, Dysphagia, Abnormal ... OMIM:617330
Monosomy 22Q13.3
Hyperactivity, Impaired pain sensation, Hair-pulling, Seizure, Bruxism ORPHA:48652
Koolen-De Vries Syndrome Due To A Point Mutation
Generalized-onset seizure, Focal hemiclonic seizure, Focal-onset seizure, Seizure, Inappropriate ... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Generalized-onset seizure, Focal hemiclonic seizure, Focal-onset seizure, Seizure, Inappropriate ... ORPHA:363958
Neurodevelopmental Disorder With Hypotonia And Brain Abnormalities
Hyperactivity, Bilateral tonic-clonic seizure, Tonic seizure, Myoclonic seizure, Self-injurious b... OMIM:619512
Hydroxykynureninuria
Abnormal repetitive mannerisms ORPHA:79155
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Generalized-onset seizure, Opisthotonus, Seizure, Abnormal repetitive mannerisms, Focal myoclonic... ORPHA:508533
Kinsship Syndrome
Bilateral tonic-clonic seizure, Focal-onset seizure, Generalized non-motor (absence) seizure, Myo... OMIM:619297
Intellectual Disability-Seizures-Abnormal Gait-Facial Dysmorphism Syndrome
Bilateral tonic-clonic seizure, Repetitive compulsive behavior, Generalized non-motor (absence) s... ORPHA:513456
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
Seizure, Abnormal repetitive mannerisms, Bilateral tonic-clonic seizure OMIM:301040
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Social and occup... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Social and occup... ORPHA:353277
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation
Seizure, Abnormal repetitive mannerisms, Simple febrile seizure, Attention deficit hyperactivity ... ORPHA:464311
Oculocerebrorenal Syndrome Of Lowe
Depression, Self-injurious behavior, Seizure, Compulsive behaviors, Attention deficit hyperactivi... ORPHA:534
Ogden Syndrome
Torticollis, Generalized-onset seizure, Bilateral tonic-clonic seizure, Irritability, Dysphagia, ... OMIM:300855
Dyrk1A-Related Intellectual Disability Syndrome
Febrile seizure (within the age range of 3 months to 6 years), Seizure, Hyperactivity, Abnormal r... ORPHA:464306
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Self-injurious behavior, Seizure, Abnormal repetitive mannerisms ORPHA:468631
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Multifocal seizures, Bilateral tonic-clonic seizure, Infantile spasms, Focal-onset seizure, Seizu... OMIM:301044
Arboleda-Tham Syndrome
Seizure, Dystonia, Abnormal repetitive mannerisms, Dysphagia OMIM:616268
Norrie Disease
Irritability, Self-injurious behavior, Seizure, Attention deficit hyperactivity disorder, Abnorma... ORPHA:649
Williams Syndrome
Ataxia, Tremor, Dysmetria, Depression, Compulsive behaviors, Attention deficit hyperactivity diso... ORPHA:904
Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb
Bilateral tonic-clonic seizure, Tremor, Generalized non-motor (absence) seizure, Self-injurious b... OMIM:612474
Intellectual Developmental Disorder, X-Linked, Syndromic, Turner Type
Seizure, Hyperactivity, Abnormal repetitive mannerisms OMIM:309590
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response, Seizure, Attention deficit hyperactivity disorder, Dysphagia, Abnor... OMIM:619522
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Abnormal repetitive mannerisms ORPHA:508498
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Abnormal repetitive mannerisms OMIM:618653
Primrose Syndrome
Restlessness, Ataxia, Aggressive behavior, Self-injurious behavior, Seizure, Tics, Attention defi... OMIM:259050
1P36 Deletion Syndrome
Polyphagia, Self-injurious behavior, Seizure, Dysphagia, Abnormal repetitive mannerisms ORPHA:1606
Mowat-Wilson Syndrome
Ataxia, Impaired pain sensation, Focal-onset seizure, Bruxism, Seizure, Status epilepticus, Atypi... ORPHA:2152
Seizures, Scoliosis, And Macrocephaly/Microcephaly Syndrome
Seizure, Abnormal repetitive mannerisms OMIM:616682
Coffin-Siris Syndrome 12
Seizure, Abnormal repetitive mannerisms OMIM:619325
Lowe Oculocerebrorenal Syndrome
Seizure, Abnormal repetitive mannerisms, Aggressive behavior OMIM:309000
Wolf-Hirschhorn Syndrome
Seizure, Abnormal repetitive mannerisms OMIM:194190
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Impaired pain sensation, Focal-onset seizure, Bruxism, Seizure, Atypical absence seizure, Dysphag... ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Impaired pain sensation, Focal-onset seizure, Bruxism, Seizure, Atypical absence seizure, Dysphag... ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Arhgap32

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Arhgap32.

No publications found that use IMPC mice or data for Arhgap32.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Arhgap32tm453763(L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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