Gene: Klk14

Order

Name kallikrein related-peptidase 14

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:2447564    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Klk14

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Klk14 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal vitreous body morphology Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 9.5E-13
increased red blood cell distribution width Klk14tm1.1(KOMP)Vlcg HOM Female postnatal 1.39E-10
long tibia Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 3.38E-8
hypoactivity Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 7.11E-8
decreased startle reflex Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.02E-7
abnormal sensory capabilities/reflexes/nociception Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.31E-5
decreased circulating triglyceride level Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.32E-5
increased circulating cholesterol level Klk14tm1.1(KOMP)Vlcg HOM Male postnatal 1.54E-5
decreased circulating chloride level Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.7E-5
decreased circulating glucose level Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 2.14E-5
abnormal retinal blood vessel morphology Klk14tm1.1(KOMP)Vlcg HOM Male postnatal 2.14E-5
abnormal behavior Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 2.76E-5
increased prepulse inhibition Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 3.88E-5
convulsive seizures Klk14tm1.1(KOMP)Vlcg HET Female Male postnatal 4.71E-5
abnormal lens morphology Klk14tm1.1(KOMP)Vlcg HOM Female postnatal 6.47E-5
decreased circulating sodium level Klk14tm1.1(KOMP)Vlcg HOM Female Male postnatal 8.81E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Bone 2 No
Bone marrow 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Epididymis 2 No (18/134)
Esophagus 2 No (7/415) (2/2)
Eye 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Quadriceps 2 No
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Submandibular gland 2 No (2/132)
Testis 2 No (2/584)
Thalamus 2 No
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No
Uterus 2 No
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system digestive system immune system integumental system trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485)
Dorsal root ganglion 2 (1/47)
Ear 2 (1/485)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Fronto-nasal process 2 (1/48)
Gut 2 (1/50) (2/2)
Hand 2 (1/485)
Head 2 (5/485)
Heart 2 (1/485) (2/3)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485)
Nose 2 (1/51)
Oral cavity 2 (1/485)
Skin 2 (1/485)
Spinal cord 2 (1/50)
Tail 2 (1/485)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    18 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    19 Images
  • Sleep Wake: Wake state (bmp file)
    12 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • X-ray: XRay Images Dorso Ventral
    19 Images
  • X-ray: XRay Images Skull Lateral Orientation
    19 Images
  • X-ray: XRay Images Lateral Orientation
    19 Images
  • Electroretinography 2: Rod and cone PDF
    7 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Klk14tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Klk14tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Klk14tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene