Gene: Sik3

Order

Name SIK family kinase 3

Synonyms
  • 9030204A07Rik
  • 5730525O22Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:2446296    Ensembl Gene    Ensembl Orthologs    My Genes   

Phenotype associations for Sik3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Sik3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased CD4-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased CD4-positive, alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased CD5-positive gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased KLRG1-positive NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased KLRG1-positive T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased Ly6C-positive mature NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased early germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased effector memory T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased germinal center B cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased memory-marker CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased memory-marker CD4-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
female infertility Sik3tm1a(EUCOMM)Hmgu HOM Female postpartum stage 0.0
increased CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased CD8-positive, alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased CD8-positive, naive alpha-beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased KLRG1+ CD8 alpha beta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased KLRG1-positive CD4-negative NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased KLRG1-positive T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased Ly6C-positive NK T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased effector memory T-helper cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased eosinophil cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased follicular B cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased granulocyte number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased memory-marker NK cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased memory-marker gamma-delta T cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
increased plasmacytoid dendritic cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 0.0
abnormal fibula morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.67E-19
abnormal tibia morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.67E-19
abnormal humerus morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.89E-18
abnormal femur morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 4.4E-17
abnormal ulna morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 4.4E-17
abnormal radius morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.21E-16
abnormal tail morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 5.34E-16
abnormal joint morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 6.3E-16
decreased circulating glucose level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 4.04E-15
abnormal thoracic cage shape Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.17E-14
increased mean corpuscular hemoglobin Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.22E-13
abnormal pelvic girdle bone morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.38E-13
abnormal cranium morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.02E-12
increased red blood cell distribution width Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 4.32E-12
abnormal coat/hair pigmentation Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 6.54E-12
decreased total body fat amount Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.28E-11
abnormal spine curvature Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.89E-11
decreased blood urea nitrogen level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 8.36E-11
abnormal vertebrae morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.56E-10
kyphosis Sik3tm1a(EUCOMM)Hmgu HOM Male postnatal 4.88E-10
abnormal bone structure Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.53E-9
decreased erythrocyte cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 6.57E-9
increased lean body mass Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.03E-8
increased circulating alkaline phosphatase level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.61E-8
decreased circulating calcium level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.74E-7
abnormal rib morphology Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.72E-7
increased bone mineral content Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.82E-7
decreased circulating insulin level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.4E-7
increased circulating sodium level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 6.68E-7
decreased Ly6C low monocyte number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.0E-6
increased neutrophil cell number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.0E-6
decreased circulating triglyceride level Sik3tm1a(EUCOMM)Hmgu HOM Male postnatal 1.67E-6
decreased circulating fructosamine level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.21E-6
decreased lean body mass Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.64E-5
decreased circulating free fatty acid level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 1.65E-5
abnormal zygomatic bone morphology Sik3tm1a(EUCOMM)Hmgu HOM Male postnatal 1.97E-5
increased circulating bilirubin level Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.13E-5
increased Ly6C high monocyte number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.26E-5
thrombocytopenia Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 2.85E-5
decreased caudal vertebrae number Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 3.04E-5
decreased circulating potassium level Sik3tm1a(EUCOMM)Hmgu HOM Male postnatal 3.51E-5
abnormal cornea morphology Sik3tm1a(EUCOMM)Hmgu HOM Female postnatal 3.53E-5
decreased body length Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 4.45E-5
improved glucose tolerance Sik3tm1a(EUCOMM)Hmgu HOM Female Male postnatal 5.57E-5

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
    180 Images
  • Spleen Immunophenotyping: Images associated with FACS analysis
    168 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    8 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Dorso Ventral
    43 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    15 Images
  • Eye Morphology: Images Slit Lamp
    8 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
Legacy Phenotype Associated Images
Xray (86)
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Female, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Female, WTSI

show all 86 images

Dysmorphology (35)
  • Sik3tm1a(EUCOMM)Hmgu
    tail, reduced tail length, HOM, Female, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    decreased body length, HOM, Female, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    decreased body length, HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    decreased body length, HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    reduced tail length, HOM, Female, WTSI

show all 35 images

Eye Morphology (15)
  • Sik3tm1a(EUCOMM)Hmgu
    abnormal cornea morphology, HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    abnormal cornea morphology, HOM, Female, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    abnormal retinal pigmentation, HOM, Female, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    abnormal retinal pigmentation, HOM, Female, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    abnormal cornea morphology, HOM, Female, WTSI

show all 15 images

Brain Histopathology (6)
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    anterior commissure, decreased anterior commissure size, HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    anterior commissure, decreased anterior commissure size, HOM, Male, WTSI
  • Sik3tm1a(EUCOMM)Hmgu
    HOM, Male, WTSI

show all 6 images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Sik3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene