The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy
Images
Zygosity
Mutant Expr
Heart atrium
N/A
heterozygote
Ambiguous
Axial skeleton
N/A
heterozygote
0.0% (0 of 2)
Brain
N/A
heterozygote
100% (2 of 2)
Central nervous system ganglion
N/A
heterozygote
Ambiguous
Cranium
N/A
heterozygote
100% (2 of 2)
Dorsal root ganglion
N/A
heterozygote
50% (1 of 2)
Ear
N/A
heterozygote
100% (2 of 2)
Embryo
N/A
heterozygote
100% (2 of 2)
Outer ear
N/A
heterozygote
0.0% (0 of 2)
Eye
N/A
heterozygote
100% (2 of 2)
Femur pre-cartilage condensation
N/A
heterozygote
Ambiguous
Footplate
N/A
heterozygote
Ambiguous
Forearm
N/A
heterozygote
Ambiguous
Forebrain
N/A
heterozygote
100% (2 of 2)
Forelimb
N/A
heterozygote
Ambiguous
Fronto-nasal process
N/A
heterozygote
50% (1 of 2)
Gut
N/A
heterozygote
50% (1 of 2)
Handplate
N/A
heterozygote
Ambiguous
Head mesenchyme
N/A
heterozygote
Ambiguous
Head
N/A
heterozygote
100% (2 of 2)
Heart ventricle
N/A
heterozygote
100% (2 of 2)
Heart
N/A
heterozygote
100% (2 of 2)
Hindbrain
N/A
heterozygote
100% (2 of 2)
Hindlimb
N/A
heterozygote
Ambiguous
Humerus pre-cartilage condensation
N/A
heterozygote
Ambiguous
Inner ear
N/A
heterozygote
100% (2 of 2)
Intestine
N/A
heterozygote
Not available
Liver
N/A
heterozygote
Ambiguous
Lower leg
N/A
heterozygote
Ambiguous
Lung
N/A
heterozygote
Ambiguous
Mandibular process
N/A
heterozygote
50% (1 of 2)
Maxillary process
N/A
heterozygote
100% (2 of 2)
Mesonephros of female
N/A
heterozygote
Not available
Mesonephros of male
N/A
heterozygote
Not available
Metanephros
N/A
heterozygote
Ambiguous
Midbrain
N/A
heterozygote
100% (2 of 2)
Nasal septum
N/A
heterozygote
100% (2 of 2)
Nose
N/A
heterozygote
100% (2 of 2)
Notochord
N/A
heterozygote
Ambiguous
Oral cavity
N/A
heterozygote
50% (1 of 2)
Outflow tract
N/A
heterozygote
Ambiguous
Pancreas
N/A
heterozygote
Ambiguous
N/A
heterozygote
0.0% (0 of 2)
Pharynx
N/A
heterozygote
50% (1 of 2)
Radius-ulna pre-cartilage condensation
N/A
heterozygote
Ambiguous
Rib pre-cartilage condensation
N/A
heterozygote
0.0% (0 of 2)
Skeleton
N/A
heterozygote
0.0% (0 of 2)
Skin
N/A
heterozygote
Ambiguous
Spinal cord
N/A
heterozygote
0.0% (0 of 2)
Stomach
N/A
heterozygote
Ambiguous
Tail somite
N/A
heterozygote
0.0% (0 of 2)
Tail
N/A
heterozygote
0.0% (0 of 2)
Thoracic vertebral cartilage condensation
N/A
heterozygote
0.0% (0 of 2)
Tongue
N/A
heterozygote
Ambiguous
Trachea
N/A
heterozygote
Ambiguous
Trunk mesenchyme
N/A
heterozygote
0.0% (0 of 2)
Umbilical artery embryonic part
N/A
heterozygote
100% (2 of 2)
Umbilical vein embryonic part
N/A
heterozygote
100% (2 of 2)
Upper arm
N/A
heterozygote
Ambiguous
Upper leg
N/A
heterozygote
Ambiguous
Urinary system
N/A
heterozygote
Ambiguous
Vibrissa
N/A
heterozygote
Ambiguous
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy
Background staining in controls (WT)
adrenal gland
0.0%
aorta
0.0%
bone
0.0%
brain
0.0%
brainstem
0.0%
brown adipose tissue
0.0%
cartilage tissue
0.0%
cecum
0.0%
cerebellum
0.0%
cerebral cortex
0.0%
esophagus
0.0%
eye
0.0%
gall bladder
0.0%
heart
0.0%
hippocampus
0.0%
hypothalamus
0.0%
kidney
0.0%
large intestine
0.0%
liver
0.0%
lower urinary tract
0.0%
lung
0.0%
lymph node
0.0%
mammary gland
0.0%
mesenteric lymph node
olfactory lobe
0.0%
oral epithelium
0.0%
ovary
0.0%
oviduct
0.0%
pancreas
0.0%
parathyroid gland
0.0%
peripheral nervous system
0.0%
peyers patch
0.0%
pituitary gland
0.0%
prostate gland
0.0%
skeletal muscle
0.0%
skin
0.0%
small intestine
0.0%
spinal cord
0.0%
spleen
0.0%
stomach
0.0%
striatum
0.0%
testis
0.0%
thymus
0.0%
thyroid gland
0.0%
trachea
0.0%
trigeminal v nerve
0.0%
urinary bladder
uterus
0.0%
vas deferens
Unavailable
vascular system
0.0%
white adipose tissue
0.0%
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy
Background staining in controls(WT)
atrium
Ambiguous
axial skeleton
Ambiguous
brain
0.0%
central nervous system ganglion
Ambiguous
cranium
Ambiguous
dorsal root ganglion
Ambiguous
ear
0.0%
embryo
0.0%
external ear
Ambiguous
eye
0.0%
femur pre-cartilage condensation
Ambiguous
footplate
0.0%
forearm
Ambiguous
forebrain
0.0%
forelimb
0.0%
fronto-nasal process
Ambiguous
gut
Ambiguous
handplate
0.0%
head
0.0%
head mesenchyme
Ambiguous
heart
0.0%
heart ventricle
Ambiguous
hindbrain
0.0%
hindlimb
0.0%
humerus pre-cartilage condensation
Ambiguous
inner ear
Ambiguous
intestine
Ambiguous
liver
0.0%
lower leg
Ambiguous
lung
0.0%
mandibular process
0.0%
maxillary process
0.0%
mesonephros of female
Ambiguous
mesonephros of male
Ambiguous
metanephros
Ambiguous
midbrain
0.0%
nasal septum
Ambiguous
nose
Ambiguous
notochord
Ambiguous
oral cavity
0.0%
outflow tract
Ambiguous
pancreas
Ambiguous
pericardium
Ambiguous
pharynx
Ambiguous
radius-ulna pre cartilage condensation
Ambiguous
rib pre-cartilage condensation
Ambiguous
skeleton
Ambiguous
skin
0.0%
spinal cord
Ambiguous
stomach
Ambiguous
tail
0.0%
tail somite group
0.0%
thoracic vertebral cartilage condensation
Ambiguous
tongue
Ambiguous
trachea
Ambiguous
trunk mesenchyme
Ambiguous
umbilical artery embryonic part
Ambiguous
umbilical vein embryonic part
Ambiguous
upper arm
Ambiguous
upper leg
Ambiguous
urinary system
Ambiguous
vibrissa
Ambiguous
Associated Images
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Eye Morphology
VIP of right fundus
16 Images
Eye Morphology
VIP of left fundus
16 Images
X-ray
XRay Images Skull Dorso Ventral Orientation
12 Images
X-ray
XRay Images Whole Body Lateral Orientation
12 Images
X-ray
XRay Images Skull Lateral Orientation
12 Images
Adult LacZ
LacZ Images Wholemount
25 Images
Eye Morphology
VIP of right eye
15 Images
X-ray
XRay Images Whole Body Dorso Ventral
12 Images
Eye Morphology
VIP of left eye
16 Images
MicroCT E18.5
Embryo reconstruction
9 Images
X-ray
XRay Images Forepaw
12 Images
Immunophenotyping
Panel A FCS file(s)
6 Images
Immunophenotyping
Panel B FCS file(s)
6 Images
Human diseases caused by Pptc7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Pptc7
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pptc7.
No publications found that use IMPC mice or data for Pptc7.
Order Mouse and ES Cells
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
