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Genes Phenotypes Help, News, Blog

Gene: Ythdc1 MGI:2443713

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
YTH domain containing 1
Synonyms:
A730098D12Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ythdc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ythdc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ythdc1.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Reduction of mRNA m6A associates with glucose metabolism via YTHDC1 in human and mice. Diabetes research and clinical practice (March 2023) Ythdc1tm1c(EUCOMM)Wtsi Ythdc1tm1a(EUCOMM)Wtsi 36878322
Downregulation of the m6A reader protein YTHDC1 leads to islet β-cell failure and diabetes. Metabolism: clinical and experimental (October 2022) Ythdc1tm1c(EUCOMM)Wtsi 36302453
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication. Blood (December 2021) Ythdc1tm1c(EUCOMM)Wtsi PMC8718631
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos. Protein & cell (April 2021) Ythdc1tm1a(EUCOMM)Wtsi PMC8160034

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ythdc1tm46169(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ythdc1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ythdc1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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