Gene: Arhgef4

Name Rho guanine nucleotide exchange factor (GEF) 4

Synonyms
  • Asef
  • 9330140K16Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:2442507   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Arhgef4

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Arhgef4 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Male postnatal 1.39E-10
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 3.97E-10
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 5.95E-9
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 3.38E-8
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Male postnatal 3.61E-8
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 3.75E-8
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM Male postnatal 4.07E-7
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 4.11E-7
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 4.71E-7
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 4.97E-7
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM Male postnatal 5.57E-7
decreased IgG1 level Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 6.4E-7
increased circulating total protein level Arhgef4tm1a(KOMP)Wtsi HOM Female postnatal 7.34E-7
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Male postnatal 1.84E-6
decreased body weight Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 2.87E-6
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Female postnatal 4.01E-6
increased circulating free fatty acid level Arhgef4tm1a(KOMP)Wtsi HOM Female postnatal 9.21E-6
decreased circulating alanine transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 9.45E-6
decreased circulating aspartate transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 1.24E-5
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM Female postnatal 1.93E-5
decreased IgE level Arhgef4tm1a(KOMP)Wtsi HOM Male postnatal 4.02E-5
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM Female Male postnatal 9.22E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No (1/2)
Olfactory lobe 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse digestive system nervous system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
nervous system (4)
  • Arhgef4tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    SPINAL CORD, HET, Female, WTSI
trunk (2)
  • Arhgef4tm1a(KOMP)Wtsi
    ESOPHAGUS, HET, Female, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    SPINAL CORD, HET, Female, WTSI
digestive system (1)
  • Arhgef4tm1a(KOMP)Wtsi
    ESOPHAGUS, HET, Female, WTSI
sensory organ (1)
  • Arhgef4tm1a(KOMP)Wtsi
    EYE, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (68)
  • Arhgef4tm1a(KOMP)Wtsi
    TRUNK, HOM, Male, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    TRUNK, HOM, Male, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    HEAD, HOM, Male, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    HEAD, HOM, Male, WTSI
  • Arhgef4tm1a(KOMP)Wtsi
    LOWER ARM, HOM, Male, WTSI

show all 68 images

Skin Histopathology (1)
  • Arhgef4tm1a(KOMP)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene