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Gene: Ifnlr1 MGI:2429859

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Gene Summary

Name:
interferon lambda receptor 1
Synonyms:
IFNLR1,  Il28ra,  CRF2-12

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal epidermal immune compartment Ifnlr1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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DSS Histology

Images

8 Images

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Anti-nuclear antibody assay

Images

6 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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Ear epidermis immunophenotyping

Images

27 Images

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Legacy Phenotype Associated Images
Ifnlr1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Ifnlr1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Ifnlr1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Ifnlr1tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Ifnlr1tm1a(EUCOMM)Wtsi
WT, Female, WTSI

View all 120 images

Ifnlr1tm1a(EUCOMM)Wtsi
abnormal eye morphology, eyelids fail to open, eye, WT, Female, WTSI
Ifnlr1tm1a(EUCOMM)Wtsi
head, WT, Female, WTSI

Human diseases caused by Ifnlr1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ifnlr1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Candidiasis, Familial, 4
Onychomycosis, Recurrent vulvovaginal candidiasis OMIM:613108
Leishmaniasis, Tegumentary, Susceptibility To
Tegumentary leishmaniasis susceptibility OMIM:602068
Varicella, Severe Recurrent
Severe recurrent varicella OMIM:600670
Human Coronavirus Sensitivity
Susceptibility to coronavirus 229e OMIM:122460
Coxsackievirus B3 Susceptibility
Recurrent viral infections OMIM:120050
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Tuftsin Deficiency
Recurrent infections OMIM:191150
Immunodeficiency 30
Recurrent mycobacterial infections, Recurrent infections OMIM:614891
Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type
Hyperkeratosis with erythema, Diffuse palmoplantar hyperkeratosis ORPHA:86923
Hyperkeratosis Lenticularis Perstans
Hyperkeratosis lenticularis perstans OMIM:144150
Ichthyosis Hystrix, Lambert Type
Hyperkeratosis, Orthokeratotic hyperkeratosis OMIM:146600
Angioma Serpiginosum, Autosomal Dominant
Hyperkeratosis OMIM:106050
Papillomatosis, Confluent And Reticulated
Hyperkeratosis OMIM:167900
Immunodeficiency 34
Recurrent mycobacterial infections, BCGosis, Pulmonary tuberculosis OMIM:300645
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Recurrent bacterial infections, Recurrent protozoan infections, Recurrent viral infections OMIM:308220
Immunodeficiency 28
Recurrent mycobacterial infections OMIM:614889
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Immunodeficiency 31A
Herpes simplex encephalitis, Recurrent mycobacterium avium complex infections, BCGitis, Recurrent... OMIM:614892
Immunodeficiency 31B
Recurrent mycobacterial infections, Herpes simplex encephalitis, Recurrent viral infections OMIM:613796
Palmoplantar Keratoderma-Deafness Syndrome
Hyperkeratosis, Palmoplantar keratoderma ORPHA:2202
Immunodeficiency 35
Recurrent respiratory infections, Recurrent mycobacterial infections, Recurrent fungal infections... OMIM:611521
Agammaglobulinemia 8A, Autosomal Dominant
Recurrent otitis media, Post-vaccination polio, Recurrent infections OMIM:616941

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ifnlr1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ifnlr1.

There are 24 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity. Cell reports (November 2022) Ifnlr1tm1a(EUCOMM)Wtsi PMC9662704
Enterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract. mBio (May 2022) Ifnlr1tm1b(EUCOMM)Wtsi PMC9239134
Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation. Journal of immunology (Baltimore, Md. : 1950) (February 2022) Ifnlr1tm1a(EUCOMM)Wtsi 35173036
Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium. eLife (February 2022) Ifnlr1tm1a(EUCOMM)Wtsi PMC8853662
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota. Autophagy (September 2021) Ifnlr1tm1a(EUCOMM)Wtsi PMC9196718
Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22. PloS one (August 2021) Ifnlr1tm1a(EUCOMM)Wtsi PMC8360596
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters. Nature communications (November 2020) Ifnlr1tm1a(EUCOMM)Wtsi PMC7672082
IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells. Journal of immunology (Baltimore, Md. : 1950) (July 2020) Ifnlr1tm1a(EUCOMM)Wtsi 32690660
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection. Science (New York, N.Y.) (June 2020) Ifnlr1tm1a(EUCOMM)Wtsi PMC7292500
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Ifnlr1tm1a(EUCOMM)Wtsi PMC7263671
Interferon-λ Receptor Expression: Novel Reporter Mouse Reveals Within- and Cross-Tissue Heterogeneity. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (May 2020) Ifnlr1tm1c(EUCOMM)Wtsi Ifnlr1tm1a(EUCOMM)Wtsi 32364818
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Ifnlr1tm1a(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Ifnlr1tm1a(EUCOMM)Wtsi PMC6671969
Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells. PLoS pathogens (July 2019) Ifnlr1tm1a(EUCOMM)Wtsi PMC6675124
Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus. Nature immunology (June 2019) Ifnlr1tm1a(EUCOMM)Wtsi PMC6642690
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell host & microbe (May 2019) Ifnlr1tm1a(EUCOMM)Wtsi 31130511
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Ifnlr1tm1a(EUCOMM)Wtsi PMC6459510
Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Nature microbiology (April 2019) Ifnlr1tm1a(EUCOMM)Wtsi PMC6588490
Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells. Cell host & microbe (November 2018) Ifnlr1tm1a(EUCOMM)Wtsi 30392829
Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PloS one (May 2018) Ifnlr1tm1a(EUCOMM)Wtsi PMC5955543
Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine. Cell host & microbe (September 2017) Ifnlr1tm1a(EUCOMM)Wtsi 28966054
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Ifnlr1tm1a(EUCOMM)Wtsi PMC5827107
IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function. Nature immunology (August 2017) Ifnlr1tm1a(EUCOMM)Wtsi 28846084
Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus. Journal of virology (March 2017) Ifnlr1tm1a(EUCOMM)Wtsi PMC5355594

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MGI Allele Allele Type Produced
Ifnlr1tm271080(L1L2_6XOspnEnh_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ifnlr1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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