Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 25% (1 of 4) |
Aorta | Wholemount images | heterozygote | 50% (2 of 4) |
Brain | Wholemount images | heterozygote | 100% (4 of 4) |
Cecum | Section images | heterozygote | 100% (4 of 4) |
Cerebellum | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Chest bone | Wholemount images | heterozygote | 50% (2 of 4) |
Colon | Section images | heterozygote | 100% (4 of 4) |
Epididymis | Section images | heterozygote | 50% (2 of 4) |
Eye | Section images | heterozygote | 50% (2 of 4) |
Gall bladder | Wholemount images | heterozygote | 50% (2 of 4) |
Harderian gland | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Ileum | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Jejunum | Wholemount images | heterozygote | 50% (2 of 4) |
Kidney | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Mammary gland | Section images | heterozygote | 25% (1 of 4) |
Mesenteric lymph node | Wholemount images | heterozygote | 50% (2 of 4) |
Midbrain | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Olfactory lobe | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Oviduct | Wholemount images | heterozygote | 25% (1 of 4) |
Parathyroid gland | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Penis | Section images | heterozygote | 25% (1 of 4) |
Pituitary gland | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Prostate gland | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Skin | Section images | heterozygote | 50% (2 of 4) |
Spinal cord | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Stomach | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Testis | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Tongue | Wholemount images | heterozygote | 25% (1 of 4) |
Trigeminal V nerve | Section images | heterozygote | 50% (2 of 4) |
Urinary bladder | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Uterus | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Vagina | Wholemount images | heterozygote | 25% (1 of 4) |
Vas deferens | Section images | heterozygote | 50% (2 of 4) |
Vesicular gland | Section images | heterozygote | 50% (2 of 4) |
Blood | N/A | heterozygote | 0.0% (0 of 4) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 4) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Cartilage tissue | N/A | heterozygote | Not available |
Cerebral cortex | N/A | heterozygote | Not available |
Diaphragm | N/A | heterozygote | 0.0% (0 of 4) |
Duodenum | N/A | heterozygote | 0.0% (0 of 4) |
Esophagus | N/A | heterozygote | 0.0% (0 of 4) |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 4) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Large intestine | N/A | heterozygote | 100% (4 of 4) |
Liver | N/A | heterozygote | 0.0% (0 of 4) |
Lower urinary tract | N/A | heterozygote | Not available |
Lung | N/A | heterozygote | 0.0% (0 of 4) |
Lymph node | N/A | heterozygote | Not available |
Mesenteric adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Ovary | N/A | heterozygote | 0.0% (0 of 4) |
Pancreas | N/A | heterozygote | 0.0% (0 of 4) |
Parotid gland | N/A | heterozygote | 0.0% (0 of 4) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Quadriceps | N/A | heterozygote | 0.0% (0 of 4) |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 4) |
Skeletal muscle | N/A | heterozygote | Not available |
Small intestine | N/A | heterozygote | 75% (3 of 4) |
Spleen | N/A | heterozygote | 0.0% (0 of 4) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Sublingual gland | N/A | heterozygote | 0.0% (0 of 4) |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 4) |
Thymus | N/A | heterozygote | 0.0% (0 of 4) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 4) |
Trachea | N/A | heterozygote | 0.0% (0 of 4) |
Vascular system | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | Not available |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | N/A | heterozygote | 66.67% (2 of 3) |
Brain | N/A | homozygote | 100% (2 of 2) |
Ear | N/A | heterozygote | 0.0% (0 of 3) |
Ear | N/A | homozygote | 50% (1 of 2) |
Embryo | N/A | heterozygote | 100% (3 of 3) |
Embryo | N/A | homozygote | 100% (2 of 2) |
Eye | N/A | heterozygote | 33.33% (1 of 3) |
Eye | N/A | homozygote | 100% (2 of 2) |
Footplate | N/A | heterozygote | 0.0% (0 of 3) |
Footplate | N/A | homozygote | 0.0% (0 of 2) |
Forebrain | N/A | heterozygote | 66.67% (2 of 3) |
Forebrain | N/A | homozygote | 100% (2 of 2) |
Forelimb | N/A | heterozygote | 0.0% (0 of 3) |
Forelimb | N/A | homozygote | 100% (2 of 2) |
Handplate | N/A | heterozygote | 0.0% (0 of 3) |
Handplate | N/A | homozygote | 50% (1 of 2) |
Head | N/A | heterozygote | 100% (3 of 3) |
Head | N/A | homozygote | 100% (2 of 2) |
Heart | N/A | heterozygote | 33.33% (1 of 3) |
Heart | N/A | homozygote | 50% (1 of 2) |
Hindbrain | N/A | heterozygote | 66.67% (2 of 3) |
Hindbrain | N/A | homozygote | 100% (2 of 2) |
Hindlimb | N/A | heterozygote | 0.0% (0 of 3) |
Hindlimb | N/A | homozygote | 50% (1 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 3) |
Liver | N/A | homozygote | 50% (1 of 2) |
Lung | N/A | heterozygote | 33.33% (1 of 3) |
Lung | N/A | homozygote | 50% (1 of 2) |
Mandibular process | N/A | heterozygote | 33.33% (1 of 3) |
Mandibular process | N/A | homozygote | 50% (1 of 2) |
Maxillary process | N/A | heterozygote | 33.33% (1 of 3) |
Maxillary process | N/A | homozygote | 50% (1 of 2) |
Midbrain | N/A | heterozygote | 66.67% (2 of 3) |
Midbrain | N/A | homozygote | 100% (2 of 2) |
Oral cavity | N/A | heterozygote | 33.33% (1 of 3) |
Oral cavity | N/A | homozygote | 50% (1 of 2) |
Skin | N/A | heterozygote | 33.33% (1 of 3) |
Skin | N/A | homozygote | 50% (1 of 2) |
Tail somite | N/A | heterozygote | 0.0% (0 of 3) |
Tail somite | N/A | homozygote | 50% (1 of 2) |
Tail | N/A | heterozygote | 100% (3 of 3) |
Tail | N/A | homozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 0.0% |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
oral cavity | 0.0% |
skin | 0.0% |
tail | 0.0% |
tail somite group | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Ube2e2 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ube2e2.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. | PLoS genetics (February 2016) | Ube2e2tm1a(KOMP)Wtsi | PMC4739719 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Ube2e2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Ube2e2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice, Tissue |
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