Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
CD207 antigen
Synonyms:
Langerin

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cd207 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd207 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Gamma-A-Globulin, Defect In Assembly Of
Decreased circulating IgA level OMIM:137050
Immune Deficiency, Familial Variable
Decreased circulating IgG level, Decreased circulating IgA level OMIM:146830
Immunodeficiency With Hyper-Igm, Type 3
Impaired Ig class switch recombination, Absence of lymph node germinal center, Impaired memory B ... OMIM:606843
Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin
Decreased circulating IgA level OMIM:235500
Immunodeficiency With Hyper-Igm, Type 2
Impaired Ig class switch recombination, Lymphadenopathy, Increased circulating IgM level, Decreas... OMIM:605258
B-Cell Expansion With Nfkb And T-Cell Anergy
Splenomegaly, Decreased circulating total IgM, Decreased specific antibody response to polysaccha... OMIM:616452
Immunodeficiency With Hyper-Igm, Type 5
Impaired Ig class switch recombination, Lymphadenopathy, Increased circulating IgM level, Decreas... OMIM:608106
Pa Polymorphism Of Alpha-2-Globulin
Abnormal immunoglobulin level OMIM:260100
Hepatic Venoocclusive Disease With Immunodeficiency
Decreased circulating IgG level, Absence of lymph node germinal center OMIM:235550
Immunodeficiency, Common Variable, 4
Decreased circulating total IgM, Complete or near-complete absence of specific antibody response ... OMIM:613494
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Persistent Polyclonal B-Cell Lymphocytosis
Splenomegaly, Decreased circulating total IgM OMIM:606445
Immunodeficiency, Common Variable, 7
Splenomegaly, Chronic (near) absent circulating IgG4, Reduced isohemagglutinin level, Chronic par... OMIM:614699
Immunoglobulin A Deficiency 2
Decreased circulating IgA level OMIM:609529
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 4
Agammaglobulinemia, Decreased circulating antibody level OMIM:616911
Histiocytosis, Progressive Mucinous
Mucinous histiocytosis OMIM:142630
Immunodeficiency, Common Variable, 3
Decreased circulating total IgM, Reduced isohemagglutinin level, Chronic decreased circulating to... OMIM:613493
Immunoerythromyeloid Hypoplasia
Decreased circulating IgG level OMIM:242880
Agammaglobulinemia 10, Autosomal Dominant
Agammaglobulinemia, Decreased circulating total IgM, Decreased circulating IgG level, Decreased c... OMIM:619707
Caspase 8 Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:607271
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Decreased circulating total IgM, Cervical lymphadenopathy, Decreased circulating IgG level OMIM:618987
Immunodeficiency 44
Decreased circulating total IgM, Decreased circulating IgA level, Abnormal circulating IgG level OMIM:616636
Immunodeficiency 86
Impaired oxidative burst, Decreased circulating IgG level, Increased circulating IgM level OMIM:619549
Immunoglobulin A Deficiency 1
Decreased circulating IgA level OMIM:137100
Immunodeficiency Due To Defect In Mapbp-Interacting Protein
Decreased circulating total IgM OMIM:610798
Agammaglobulinemia 4, Autosomal Recessive
Agammaglobulinemia, Decreased circulating total IgM, Decreased circulating IgG level, Decreased c... OMIM:613502
Neutropenia-Monocytopenia-Deafness Syndrome
Abnormal macrophage morphology, Abnormality of neutrophils ORPHA:2690
Agammaglobulinemia 5, Autosomal Dominant
Agammaglobulinemia OMIM:613506
Immunodeficiency, Common Variable, 14
Decreased circulating total IgM, Decreased specific antibody response to vaccination, Decreased c... OMIM:617765
Agammaglobulinemia 2, Autosomal Recessive
Agammaglobulinemia, Decreased circulating total IgM, Decreased circulating IgA level OMIM:613500
Lymphoma, Hodgkin, Classic
Polyclonal elevation of IgM OMIM:236000
Asthma, Short Stature, And Elevated Iga
Increased circulating IgA level OMIM:208600
Transcobalamin Deficiency
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... ORPHA:859
Immunodeficiency 24
Decreased circulating IgG level, Defective T cell proliferation, Reduced antigen-specific T cell ... OMIM:615897
Severe Combined Immunodeficiency, X-Linked
Reduced natural killer cell activity, Agammaglobulinemia, Decreased circulating total IgM, Decrea... OMIM:300400
Immunodeficiency, Partial Combined, With Absence Of Hla Determinants And Beta-2-Microglobulin From Lymphocytes
Decreased circulating IgG level OMIM:242870
Immunodeficiency 33
Decreased circulating total IgM, Increased circulating IgA level OMIM:300636
Immunodeficiency, Common Variable, 5
Chronic decreased circulating total IgG OMIM:613495
Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections
Decreased circulating IgG level, Decreased circulating total IgM, Increased circulating interleuk... OMIM:618944
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Agammaglobulinemia, Hypoplasia of the thymus OMIM:200900
Agammaglobulinemia 6, Autosomal Recessive
Agammaglobulinemia, Decreased circulating total IgM, Decreased circulating IgG level, Decreased c... OMIM:612692
Immunodeficiency 61
Agammaglobulinemia, Decreased circulating total IgM, Decreased circulating IgG2 level, Decreased ... OMIM:300310
Immunodeficiency 105
Absence of lymph node germinal center, Decreased circulating antibody level, Hepatosplenomegaly, ... OMIM:619924
Immunodeficiency 62
Decreased circulating IgG level, Decreased circulating total IgM, Reduced isohemagglutinin level,... OMIM:618459
Intellectual Developmental Disorder, X-Linked, Syndromic, Chudley-Schwartz Type
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:300861
Immunodeficiency, Common Variable, 2
Impaired T cell function, Follicular hyperplasia, Splenomegaly, Lymphadenopathy, Decreased circul... OMIM:240500
Macroglobulinemia, Waldenstrom, Susceptibility To, 1
Monoclonal immunoglobulin M proteinemia, Polyclonal elevation of IgM OMIM:153600
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:611926
Undritz Anomaly
Hypersegmentation of neutrophil nuclei OMIM:191500
Immunodeficiency 70
Decreased circulating total IgA, Decreased circulating total IgM, Decreased circulating total IgG... OMIM:618969
Immunodeficiency Due To Selective Anti-Polysaccharide Antibody Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... ORPHA:70593
Agammaglobulinemia 8B, Autosomal Recessive
Splenomegaly, Agammaglobulinemia, Decreased circulating total IgM, Decreased circulating IgE, Par... OMIM:619824
Facial Dysmorphism, Immunodeficiency, Livedo, And Short Stature
Decreased circulating total IgM OMIM:615139
Immunodeficiency 50
Decreased circulating antibody level OMIM:300988
Immunodeficiency, Common Variable, 1
Impaired T cell function, Splenomegaly, Lymphadenopathy, Decreased circulating total IgM, Decreas... OMIM:607594
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Partial absence of specific antibody response to tetanus vaccine, Lymphadenop... OMIM:618261
Immunodeficiency 11A
Agammaglobulinemia, Reduced antigen-specific T cell proliferation, Decreased circulating antibody... OMIM:615206
Epilepsy-Telangiectasia Syndrome
Decreased circulating IgA level, Decreased circulating antibody level ORPHA:1951
Benign Cephalic Histiocytosis
Histiocytosis ORPHA:157997
Immunodeficiency 14B, Autosomal Recessive
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... OMIM:619281
Histiocytosis, Familial Lipochrome
Increased circulating antibody level OMIM:235900
Immunodeficiency 8 With Lymphoproliferation
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:615401
Spastic Ataxia-Corneal Dystrophy Syndrome
Decreased circulating antibody level ORPHA:2572
Combined Cellular And Humoral Immune Defects With Granulomas
Decreased circulating IgG level OMIM:233650
Immunodeficiency 60 And Autoimmunity
Splenomegaly, Decreased circulating total IgM, Decreased circulating IgE, Decreased circulating I... OMIM:618394
Agammaglobulinemia 8A, Autosomal Dominant
Agammaglobulinemia OMIM:616941
Immunodeficiency 11B With Atopic Dermatitis
Decreased circulating total IgM, Increased circulating IgE level OMIM:617638
Immunodeficiency, Developmental Delay, And Hypohomocysteinemia
Decreased circulating IgA level, Decreased circulating antibody level OMIM:617744
Immunodeficiency 14A With Lymphoproliferation, Autosomal Dominant
Splenomegaly, Lymphadenopathy, Increased circulating IgM level, Decreased circulating IgG2 level,... OMIM:615513
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency
Absent peripheral lymph nodes in presence of infection, Abnormal immunoglobulin level, Increased ... ORPHA:98813
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 2
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... OMIM:614069
Polyneuropathy Associated With Igm Monoclonal Gammopathy With Anti-Mag
Monoclonal immunoglobulin M proteinemia ORPHA:639
Immunodeficiency 96
Decreased circulating total IgM, Defective T cell proliferation, Decreased circulating IgG level,... OMIM:619774
Microcephalic Primordial Dwarfism, Toriello Type
Decreased circulating total IgM, Decreased circulating IgG level ORPHA:2643
Immunodeficiency 95
Decreased circulating IgG3 level, Increased circulating IgG3 level OMIM:619773
Papular Xanthoma
Histiocytosis ORPHA:158008
Agammaglobulinemia 7, Autosomal Recessive
Agammaglobulinemia, Panhypogammaglobulinemia OMIM:615214
Thrombocytopenia With Elevated Serum Iga And Renal Disease
Increased circulating IgA level OMIM:314000
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Splenomegaly, Lymphadenopathy, Decreased circulating antibody level, Decreased circulating total ... OMIM:616100
Autoinflammation, Antibody Deficiency, And Immune Dysregulation
Decreased circulating total IgM, Decreased circulating IgA level OMIM:614878
Immunodeficiency 15B
Agammaglobulinemia, Decreased lymphocyte proliferation in response to mitogen, Decreased circulat... OMIM:615592
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias
Absent specific antibody response, Follicular hyperplasia, Lymphadenopathy, Decreased circulating... OMIM:619846
Immunodeficiency 109 With Lymphoproliferation
Generalized lymphadenopathy, Decreased lymphocyte proliferation in response to anti-CD3, Splenome... OMIM:620282
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Increased circulating IgG level, Increased circulating IgM level, Lymphadenopathy, Fluctuating sp... OMIM:619220
Immunodeficiency With Hyper-Igm, Type 1
Dysgammaglobulinemia, Impaired Ig class switch recombination, Increased circulating IgA level, Ab... OMIM:308230
Immunodeficiency 48
Splenomegaly, Panhypogammaglobulinemia OMIM:269840
Immunodeficiency 64 With Lymphoproliferation
Increased circulating IgA level, Mediastinal lymphadenopathy, Cervical lymphadenopathy, Splenomeg... OMIM:618534
Autoinflammatory Disease, Systemic, X-Linked
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:301081
Immunodeficiency 102
Increased circulating interleukin 6 concentration, Partial absence of specific antibody response ... OMIM:301082
Neurodevelopmental Disorder With Dysmorphic Facies And Ischiopubic Hypoplasia
Splenomegaly, Decreased circulating total IgM, Decreased circulating IgG level OMIM:620210
Sodium-Dependent Multivitamin Transporter Deficiency
Decreased circulating IgG level OMIM:618973
Axonal Polyneuropathy Associated With Igg/Igm/Iga Monoclonal Gammopathy
Cryoglobulinemia, Monoclonal immunoglobulin M proteinemia ORPHA:209004
Immunodeficiency 85 And Autoimmunity
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgE, Decr... OMIM:619510
Myeloma, Multiple
Paraproteinemia OMIM:254500
Immunodeficiency 25
Increased circulating IgA level, Increased circulating IgE level, Increased circulating IgG level... OMIM:610163
Whim Syndrome 1
Decreased circulating IgG level, Decreased circulating antibody level OMIM:193670
Neutropenia, Chronic Familial
Increased circulating antibody level OMIM:162700
Rosaï-Dorfman Disease
Dysgammaglobulinemia, Lymphadenopathy ORPHA:158014
Combined Immunodeficiency, X-Linked
Decreased circulating IgG level OMIM:312863
Immunodeficiency 93 And Hypertrophic Cardiomyopathy
Agammaglobulinemia, Decreased circulating total IgM, Decreased circulating IgG level OMIM:619705
Immunodeficiency 37
Decreased circulating antibody level OMIM:616098
Chondroitin-6-Sulfaturia, Defective Cellular Immunity, Nephrotic Syndrome
Decreased circulating IgA level OMIM:215250
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Hepatosplenomegaly, Increased circulating antibody level, Decreased lymphocyte proliferation in r... ORPHA:169160
Riddle Syndrome
Decreased circulating IgG level OMIM:611943
Hyper-Ige Syndrome 4A, Autosomal Dominant, With Recurrent Infections
Decreased circulating total IgM, Decreased circulating IgG level, Increased circulating IgE level... OMIM:619752
Immunodeficiency, Common Variable, 10
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:615577
Neuronal Intestinal Pseudoobstruction
Decreased circulating antibody level ORPHA:99811
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Lymphadenitis, Decreased circulating antibody level, Hepatosplenomegaly, Decreased circulating to... ORPHA:331206
Xq28 (MECP2) duplication
Decreased circulating IgA level DECIPHER:45
Immunoneurologic Disorder, X-Linked
Decreased circulating IgG2 level OMIM:300076
Immunoglobulin Kappa Light Chain Deficiency
Abnormal immunoglobulin level OMIM:614102
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation
Hepatosplenomegaly, Increased circulating IgG level, Increased circulating IgE level, Lymphadenop... OMIM:618982
Immunodeficiency, Common Variable, 13
Decreased circulating antibody level OMIM:616873
Agammaglobulinemia 3, Autosomal Recessive
Agammaglobulinemia, Absent isohemagglutinin level OMIM:613501
Immunodeficiency 36 With Lymphoproliferation
Splenomegaly, Increased circulating IgM level, Decreased circulating IgG level, Decreased circula... OMIM:616005
Sneddon Syndrome
Decreased circulating total IgM OMIM:182410
Deafness, Neural, With Atypical Atopic Dermatitis
Increased circulating IgE level OMIM:221700
Immunodeficiency 22
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgE, Decr... OMIM:615758
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency
Splenomegaly, Lymphadenopathy, Decreased circulating antibody level, Decreased circulating total ... ORPHA:436159
Alpha-Heavy Chain Disease
Splenomegaly, Dysgammaglobulinemia, Lymphadenopathy ORPHA:100025
Immunodeficiency 92
Partial absence of specific antibody response to tetanus vaccine, Decreased circulating IgG level... OMIM:619652
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Decreased circulating IgG level, Decreased circulating IgA level ORPHA:275
Immunodeficiency 52
Splenomegaly, Lymphadenopathy, Decreased circulating antibody level OMIM:617514
Immunodeficiency 43
Decreased circulating IgG level, Decreased specific antibody response to polysaccharide vaccine, ... OMIM:241600
Kimura Disease
Increased circulating IgE level, Lymphadenopathy, Follicular hyperplasia ORPHA:482
Immunodeficiency 97 With Autoinflammation
Mediastinal lymphadenopathy, Splenomegaly, Decreased circulating antibody level, Hepatosplenomega... OMIM:619802
Immunodeficiency, Common Variable, 11
Decreased circulating IgG level, Increased circulating IgE level OMIM:615767
Autoimmune Disease, Multisystem, Infantile-Onset, 2
Decreased specific pneumococcal antibody level OMIM:617006
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Splenomegaly, Hepatosplenomegaly, Lymphadenopathy, Abnormal natural killer cell physiology, Decre... OMIM:613101
Neutropenia, Severe Congenital, 2, Autosomal Dominant
Monocytosis, B lymphocytopenia, Neutropenia OMIM:613107
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Increased circulating IgA level, Follicular hyperplasia, S... OMIM:601859
Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia
Splenomegaly, Decreased circulating antibody level OMIM:618042
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Abnormal immunoglobulin level, Increased circulating IgG level, Lymph node hypoplasia, Decreased ... ORPHA:276
Hemophagocytic Lymphohistiocytosis, Familial, 3
Hemophagocytosis, Granulocytopenia, Anemia, Hepatosplenomegaly OMIM:608898
X-Linked Immunoneurologic Disorder
Decreased circulating IgG2 level ORPHA:2571
Transcobalamin Ii Deficiency
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:275350
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Increased circulating IgE level, Increased circulating IgM level, Hypoplasia of the thymus, Reduc... OMIM:617241
Microcephaly With Chemotactic Defect And Transient Hypogammaglobulinemia
Transient hypogammaglobulinemia of infancy OMIM:251240
Hyper-Ige Syndrome 2, Autosomal Recessive, With Recurrent Infections
Increased circulating IgG level, Increased circulating IgE level, Decreased circulating total IgM OMIM:243700
Ige Responsiveness, Atopic
Increased circulating IgE level OMIM:147050
Lymphopenic Hypergammaglobulinemia, Antibody Deficiency, Autoimmune Hemolytic Anemia, And Glomerulonephritis
Increased circulating antibody level OMIM:247800
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
Increased circulating IgM level, Decreased circulating IgA level OMIM:242860
Immunodeficiency 46
Decreased circulating antibody level OMIM:616740
Immunodeficiency 89 And Autoimmunity
Reduced circulating interleukin 17A concentration, Reduced circulating interleukin 23 concentrati... OMIM:619632
Hyper-Ige Syndrome 3, Autosomal Recessive, With Recurrent Infections
Increased circulating IgE level, Decreased circulating IgA level OMIM:618282
Ataxia-Pancytopenia Syndrome
Splenomegaly, Abnormal platelet function, Decreased circulating antibody level ORPHA:2585
Ectodermal Dysplasia And Immunodeficiency 1
Dysgammaglobulinemia, Reduced natural killer cell activity, Increased circulating IgA level, Incr... OMIM:300291
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Mediastinal lymphadenopathy, Splenomegaly, Decreased specific anti-polysaccharide antibody level,... OMIM:300853
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 3
Agammaglobulinemia, Decreased circulating antibody level OMIM:616910
Rasmussen Subacute Encephalitis
Decreased circulating total IgA ORPHA:1929
Alopecia Antibody Deficiency
Decreased circulating antibody level ORPHA:1006
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Decreased lymphocyte proliferation in response to anti-CD3, Increased circulating IgE level, Decr... OMIM:606367
Bone Marrow Failure Syndrome 4
Bone marrow hypocellularity, Decreased circulating antibody level OMIM:618116
Dyskeratosis Congenita, Digenic
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:620040
Primary Intestinal Lymphangiectasia
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... ORPHA:90362
Immunodeficiency, Common Variable, 8, With Autoimmunity
Generalized lymphadenopathy, Splenomegaly, Lymphadenopathy, Decreased circulating total IgM, Decr... OMIM:614700
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Partial IgA deficiency, Lack of T cell function, Hepatosplenomegaly, Decreased circulating total ... ORPHA:35078
Osteopetrosis, Autosomal Recessive 7
Splenomegaly, Decreased circulating total IgM, Decreased circulating IgG level, Decreased circula... OMIM:612301
Agammaglobulinemia, X-Linked
Agammaglobulinemia, Decreased circulating total IgM, Lymph node hypoplasia, Decreased circulating... OMIM:300755
Immunodeficiency, Common Variable, 6
Complete or near-complete absence of specific antibody response to tetanus vaccine, Chronic decre... OMIM:613496
Dyskeratosis Congenita, Autosomal Recessive 5
Bone marrow hypocellularity, Decreased circulating antibody level OMIM:615190
Immunodeficiency 27A
Splenomegaly, Enlarged mesenteric lymph node, Lymphadenopathy, Increased circulating IgG level, I... OMIM:209950
Congenital Disorder Of Glycosylation, Type Iib
Decreased circulating IgA level, Decreased circulating antibody level OMIM:606056
Lambert Syndrome
Decreased circulating antibody level ORPHA:1296
X-Linked Intellectual Disability-Hypogammaglobulinemia-Progressive Neurological Deterioration Syndrome
Decreased circulating antibody level ORPHA:85317
Lymphangiectasia, Intestinal
Decreased circulating IgG level OMIM:152800
Lymphoproliferative Syndrome, X-Linked, 1
Dysgammaglobulinemia, Reduced natural killer cell activity, Splenomegaly, Decreased circulating a... OMIM:308240
Cernunnos-Xlf Deficiency
Decreased circulating antibody level ORPHA:169079
Activated Pi3K-Delta Syndrome
Splenomegaly, Increased circulating IgM level, Lymphadenopathy, Decreased circulating antibody level ORPHA:397596
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
Absent specific antibody response, Aplasia of the thymus, Splenomegaly, Increased circulating IgE... OMIM:102700
Congenital Disorder Of Glycosylation, Type Iir
Decreased circulating antibody level OMIM:301045
Proteasome-Associated Autoinflammatory Syndrome 2
Increased circulating IgG level, Abnormal circulating IgM level, Lymphadenopathy, Increased circu... OMIM:618048
Smith-Kingsmore Syndrome
Decreased circulating IgA level OMIM:616638
Erythema Elevatum Diutinum
Increased circulating antibody level ORPHA:90000
X-Linked Severe Congenital Neutropenia
Monocytopenia, Neutropenia ORPHA:86788
Schnitzler Syndrome
Splenomegaly, Increased circulating IgM level, Lymphadenopathy ORPHA:37748
Mogs-Cdg
Hepatosplenomegaly, Decreased circulating antibody level, Decreased circulating total IgM, Decrea... ORPHA:79330
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
Decreased circulating antibody level ORPHA:1116
Congenital Disorder Of Glycosylation, Type Ig
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:607143
Myotonic Dystrophy 2
Decreased circulating total IgM, Decreased circulating IgG level OMIM:602668
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive
Panhypogammaglobulinemia OMIM:601457
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome
Decreased circulating IgA level ORPHA:457485
Lymphoproliferative Syndrome, X-Linked, 2
Splenomegaly, Decreased circulating antibody level OMIM:300635
Immunodeficiency 57 With Autoinflammation
Partial absence of specific antibody response to tetanus vaccine, Decreased circulating antibody ... OMIM:618108
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Increased circulating IgA level, Increased circulating IgE level, Hepatosplenomegaly, Lymphadenop... ORPHA:169154
Autoimmune Lymphoproliferative Syndrome, Type Iia
Chronic noninfectious lymphadenopathy, Increased circulating IgA level, Follicular hyperplasia, S... OMIM:603909
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 6
Bone marrow hypocellularity, Decreased circulating antibody level OMIM:619767
Immunodeficiency 47
Accessory spleen, Decreased circulating total IgG, Splenomegaly, Decreased circulating antibody l... OMIM:300972
Agammaglobulinemia 9, Autosomal Recessive
Agammaglobulinemia OMIM:619693
Lymphoproliferative Syndrome 2
Splenomegaly, Hepatosplenomegaly, Lymphadenopathy, Decreased circulating antibody level, Decrease... OMIM:615122
Immunodeficiency, Common Variable, 12, With Autoimmunity
Decreased circulating antibody level OMIM:616576
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Splenomegaly, Increased circulating IgG level, Lymphadenopathy OMIM:618495
Autoimmune Disease, Multisystem, With Facial Dysmorphism
Hypersplenism, Splenomegaly, Decreased circulating IgA level OMIM:613385
Reticular Dysgenesis
Decreased circulating antibody level ORPHA:33355
Combined Immunodeficiency With Facio-Oculo-Skeletal Anomalies
Decreased lymphocyte proliferation in response to anti-CD3, Decreased circulating antibody level,... ORPHA:221139
Selective Igm Deficiency
Lymphadenitis, Paraproteinemia, Lymphadenopathy, Decreased circulating total IgM, Decreased speci... ORPHA:331235
Autoimmune Lymphoproliferative Syndrome, Type Iii
Generalized lymphadenopathy, Reduced natural killer cell activity, Follicular hyperplasia, Medias... OMIM:615559
Riddle Syndrome
Generalized lymphadenopathy, Decreased circulating total IgM, Decreased circulating IgG level, De... ORPHA:420741
Boutonneuse Fever
Increased circulating IgG level, Cervical lymphadenopathy, Increased circulating IgM level, Lymph... ORPHA:83313
Ataxia-Telangiectasia
Decreased circulating IgG level, Hypoplasia of the thymus, Decreased circulating IgG2 level, Defe... OMIM:208900
Calcific Aortic Disease With Immunologic Abnormalities, Familial
Increased circulating antibody level OMIM:114065
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Decreased lymphocyte proliferation in response to anti-CD3, Absent peripheral lymph nodes in pres... OMIM:600802
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Increased circulating IgM level, Lymphadenopathy, Increased circulating IgA level OMIM:617099
Lipodystrophy, Congenital Generalized, Type 4
Splenomegaly, Decreased circulating IgA level OMIM:613327
Bloom Syndrome
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:210900
Autoinflammation With Arthritis And Dyskeratosis
Splenomegaly, Increased circulating IgG level, Increased circulating IgA level OMIM:617388
Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency
Decreased circulating total IgM, Decreased circulating IgG level, Decreased specific pneumococcal... ORPHA:183675
Lymphoproliferative Syndrome 1
Splenomegaly, Decreased circulating IgG level, Lymphadenopathy, Decreased circulating antibody level OMIM:613011
Secondary Intestinal Lymphangiectasia
Decreased circulating total IgM, Decreased circulating IgG1 level, Decreased circulating IgA leve... ORPHA:90363
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Increased circulating IgA level, Hypersplenism, Splenomega... ORPHA:3261
Roifman Syndrome
Hepatosplenomegaly, Decreased T cell activation, Lymphadenopathy, Decreased circulating antibody ... ORPHA:353298
Okur-Chung Neurodevelopmental Syndrome
Decreased circulating IgG level, Decreased circulating IgA level, Decreased circulating antibody ... OMIM:617062
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies
Hepatosplenomegaly, Lymphadenopathy, Decreased circulating antibody level OMIM:619750
Celiac Disease, Susceptibility To, 1
Decreased circulating IgA level OMIM:212750
Maternal Uniparental Disomy Of Chromosome 1
Panhypogammaglobulinemia ORPHA:251009
Iga Pemphigus
Monoclonal elevation of circulating IgA, Increased circulating IgA level ORPHA:555905
Ring Chromosome 21 Syndrome
Decreased circulating antibody level ORPHA:1445
Congenital Disorder Of Glycosylation, Type Ia
Decreased circulating IgG level, Decreased circulating IgA level OMIM:212065
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Generalized lymphadenopathy, Aplasia of the thymus, Splenomegaly, Increased circulating IgE level... OMIM:602450
Thrombocytopenia 1
Increased circulating IgE level, Increased circulating IgA level OMIM:313900
Angiostrongyliasis
Increased circulating specific IgE antibody, Increased circulating IgG level, Increased circulati... ORPHA:74
Bloom Syndrome
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... ORPHA:125
Bone Marrow Failure Syndrome 5
Decreased circulating antibody level OMIM:618165
Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia
Decreased circulating antibody level OMIM:617780
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy, Increased circulating IgA level ORPHA:343
Adult Idiopathic Neutropenia
Increased circulating IgM level ORPHA:2688
Primordial Dwarfism-Immunodeficiency-Lipodystrophy Syndrome
Accessory spleen, Decreased circulating total IgM, Decreased circulating IgG level, Decreased cir... OMIM:620005
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Generalized lymphadenopathy, Decreased lymphocyte proliferation in response to anti-CD3, Partial ... OMIM:618986
Agammaglobulinemia 1, Autosomal Recessive
Agammaglobulinemia, Panhypogammaglobulinemia, Decreased circulating antibody level OMIM:601495
Spondyloepimetaphyseal Dysplasia, Krakow Type
Decreased circulating total IgM OMIM:618162
Ataxia-Telangiectasia
Decreased circulating antibody level ORPHA:100
Griscelli Syndrome
Lymphadenopathy, Splenomegaly, Bone marrow hypocellularity, Decreased circulating antibody level ORPHA:381
Monosomy 18Q
Decreased circulating IgA level ORPHA:1600
Wolfram Syndrome 2
Impaired collagen-induced platelet aggregation, Decreased circulating antibody level OMIM:604928
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Increased circulating IgE level, Decreased circulating antibody level, Decreased circulating tota... ORPHA:508533
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome
Decreased circulating total IgM, Decreased circulating IgA level ORPHA:369837
Multiple Myeloma
Increased circulating IgA level, Splenomegaly, Lymphadenopathy, Decreased circulating antibody le... ORPHA:29073
Sting-Associated Vasculopathy, Infantile-Onset
Increased circulating IgG level, Follicular hyperplasia, Paratracheal lymphadenopathy, Increased ... OMIM:615934
Bare Lymphocyte Syndrome, Type Ii
Agammaglobulinemia, Cutaneous anergy, Panhypogammaglobulinemia OMIM:209920
Immunodeficiency 56
Panhypogammaglobulinemia OMIM:615207
Wiskott-Aldrich Syndrome
Reduced natural killer cell activity, Increased circulating IgA level, Increased circulating IgE ... OMIM:301000
Immunodeficiency 98 With Autoinflammation, X-Linked
Splenomegaly, Decreased circulating IgG level, Bone marrow hypocellularity, Lymphadenopathy OMIM:301078
Autoimmune Disease, Multisystem, Infantile-Onset, 1
Hepatosplenomegaly, Decreased circulating antibody level OMIM:615952
Immunodeficiency 12
Absent isohemagglutinin level, Complete or near-complete absence of specific antibody response to... OMIM:615468
Dubowitz Syndrome
Decreased circulating IgG level, Decreased circulating IgA level OMIM:223370
Familial Hemophagocytic Lymphohistiocytosis
Increased circulating interleukin 6 concentration, Reduced natural killer cell activity, Splenome... ORPHA:540
Hyper-Igd Syndrome
Increased circulating IgA level, Lymphadenitis, Splenomegaly, Hepatosplenomegaly, Lymphadenopathy... OMIM:260920
Immunodeficiency 82 With Systemic Inflammation
Decreased circulating total IgG, Follicular hyperplasia, Splenomegaly, Lymphadenopathy, Decreased... OMIM:619381
Tempi Syndrome
Increased circulating IgG level ORPHA:284227
Immunodeficiency By Defective Expression Of Mhc Class Ii
Lack of T cell function, Decreased circulating antibody level, Abnormality of humoral immunity, D... ORPHA:572
Hereditary Folate Malabsorption
Decreased circulating antibody level ORPHA:90045
Good Syndrome
Mediastinal lymphadenopathy, Decreased circulating antibody level ORPHA:169105
Macrocephaly/Autism Syndrome
Splenomegaly, Decreased circulating antibody level OMIM:605309
Netherton Syndrome
Increased circulating IgE level, Decreased circulating antibody level ORPHA:634
Trichothiodystrophy 3, Photosensitive
Increased circulating IgA level OMIM:616395
Icf Syndrome
Decreased circulating antibody level ORPHA:2268
Simple Cryoglobulinemia
Monoclonal elevation of circulating IgA, Monoclonal immunoglobulin M proteinemia, Paraproteinemia... ORPHA:91139
Autosomal Agammaglobulinemia
Agammaglobulinemia ORPHA:33110
Netherton Syndrome
Decreased circulating IgG level, Increased circulating IgE level OMIM:256500
Zika Virus Disease
Increased circulating IgM level ORPHA:448237
Vici Syndrome
Decreased circulating IgG2 level, Decreased circulating IgG level ORPHA:1493
Mohr-Tranebjaerg Syndrome
Agammaglobulinemia ORPHA:52368
Lassa Fever
Increased circulating IgM level ORPHA:99824
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Agammaglobulinemia, Hypoplasia of the thymus, Decreased circulating antibody level OMIM:243150
Sideroblastic Anemia With B-Cell Immunodeficiency, Periodic Fevers, And Developmental Delay
Splenomegaly, Decreased circulating antibody level OMIM:616084
Alg12-Cdg
Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine, Abn... ORPHA:79324
Immunodeficiency 59 And Hypoglycemia
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:233600
Thymoma
Abnormal lymphocyte physiology, Abnormal lymphocyte proliferation, Decreased circulating antibody... ORPHA:99867
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Decreased circulating antibody level OMIM:226300
X-Linked Agammaglobulinemia
Agammaglobulinemia ORPHA:47
Liver Failure, Infantile, Transient
Decreased circulating IgG level OMIM:613070
Pgm3-Cdg
Increased circulating IgA level, Increased circulating IgE level, Increased circulating IgG level... ORPHA:443811
Common Variable Immunodeficiency
Splenomegaly, Lymphadenopathy, Decreased circulating antibody level ORPHA:1572
Immunodeficiency 23
Increased circulating IgG level, Increased circulating IgE level, Increased circulating IgM level OMIM:615816
Congenital Disorder Of Glycosylation, Type Iil
Splenomegaly, Decreased specific anti-polysaccharide antibody level, Impaired T cell function OMIM:614576
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Absence of lymph node germinal center, Hepatosplenomegaly, Abnormal circulating interferon-gamma ... ORPHA:79124
Igg4-Related Submandibular Gland Disease
Increased circulating IgG4 level, Increased circulating IgE level, Lymphadenopathy, Increased cir... ORPHA:449432
Distal Deletion 19P
Decreased circulating antibody level ORPHA:96129
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Agammaglobulinemia ORPHA:935
Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities
Decreased circulating antibody level OMIM:617425
Primary Biliary Cholangitis
Increased circulating IgM level, Increased circulating IgA level ORPHA:186
Immunodeficiency 58
Decreased specific antibody response to vaccination, Decreased T cell activation, Decreased circu... OMIM:618131
Autoimmune Hepatitis
Splenomegaly, Increased circulating IgG level, Increased circulating antibody level ORPHA:2137
Mannosidosis, Alpha B, Lysosomal
Splenomegaly, Decreased circulating antibody level OMIM:248500
Schimke Immunoosseous Dysplasia
Abnormal immunoglobulin level, Decreased circulating antibody level OMIM:242900
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Decreased circulating total IgM ORPHA:83617
Igg4-Related Dacryoadenitis And Sialadenitis
Increased circulating IgM level, Lymphadenopathy, Increased circulating IgG4 level, Increased cir... ORPHA:79078
Mucopolysaccharidosis-Plus Syndrome
Splenomegaly, Increased circulating IgM level, Bone marrow hypocellularity OMIM:617303
Mgat2-Cdg
Decreased circulating IgG level, Impaired platelet aggregation, Decreased lymphocyte proliferatio... ORPHA:79329
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Panhypogammaglobulinemia OMIM:307200
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Defective T cell proliferation, Increased circulating IgG level, Decreased T cell activation, Inc... OMIM:618213
Cowden Syndrome 1
Decreased circulating antibody level OMIM:158350
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Increased circulating IgG level, Increased circulating IgM level ORPHA:562639
Insulin-Resistance Syndrome Type B
Increased circulating IgG level, Decreased circulating complement factor B concentration, Increas... ORPHA:2298
Say-Barber-Miller Syndrome
Decreased circulating IgG level, Transient hypogammaglobulinemia of infancy, Impaired neutrophil ... ORPHA:3132
Immunodeficiency 17
Chronic decreased cirulating IgG2 OMIM:615607
Diarrhea 10, Protein-Losing Enteropathy Type
Decreased circulating antibody level OMIM:618183
Whim Syndrome
Lymphadenitis, Decreased circulating antibody level ORPHA:51636
Rift Valley Fever
Increased circulating IgG level, Increased circulating IgM level ORPHA:319251
Viss Syndrome
Increased circulating IgG level, Increased circulating IgE level, Decreased circulating IgA level OMIM:619472
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Splenomegaly, Lymphadenopathy, Hepatosplenomegaly, Decreased circulating antibody level, Bone mar... OMIM:615688
Autoimmune Polyendocrinopathy Type 4
Aplasia/Hypoplasia of the spleen, Decreased circulating antibody level ORPHA:227990
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Increased circulating IgM level, Decreased circulating IgG level, Bone marrow hypocellularity, He... ORPHA:505248
Proteasome-Associated Autoinflammatory Syndrome 1
Increased circulating interleukin 6 concentration, Increased circulating interleukin 8 concentrat... OMIM:256040
Trichothiodystrophy 1, Photosensitive
Decreased circulating IgG level OMIM:601675
Autoimmune Polyendocrinopathy Type 3
Aplasia/Hypoplasia of the spleen, Decreased circulating antibody level ORPHA:227982
Postinfectious Vasculitis
Abnormality of humoral immunity, Cryoglobulinemia, Increased circulating antibody level, Increase... ORPHA:48435
Japanese Encephalitis
Increased circulating IgM level, Increased circulating antibody level ORPHA:79139
Tick-Borne Encephalitis
Increased circulating IgG level, Abnormality of serum cytokine level, Increased circulating IgM l... ORPHA:297
Hennekam Syndrome
Splenomegaly, Lymphadenopathy, Decreased circulating antibody level ORPHA:2136
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Decreased circulating antibody level ORPHA:79396
Trichohepatoenteric Syndrome 1
Splenomegaly, Decreased circulating antibody level OMIM:222470
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Decreased circulating antibody level ORPHA:293978
Coccidioidomycosis
Abnormality of the spleen, Mediastinal lymphadenopathy, Lymphadenopathy, Increased circulating Ig... ORPHA:228123
Vici Syndrome
Decreased circulating IgG2 level, Cutaneous anergy, Decreased circulating IgG level, Decreased T ... OMIM:242840
Primary Sjögren Syndrome
Decreased circulating antibody level, Lymphadenopathy, Increased circulating antibody level, Decr... ORPHA:289390
Syndromic Diarrhea
Splenomegaly, Hypoplasia of the thymus, Panhypogammaglobulinemia ORPHA:84064
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Hepatosplenomegaly, Decreased circulating antibody level ORPHA:247598
Cartilage-Hair Hypoplasia
Decreased circulating antibody level ORPHA:175
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Decreased circulating IgG level, Hepatosplenomegaly OMIM:618278
Trichothiodystrophy
Panhypogammaglobulinemia ORPHA:33364
Brucellosis
Hypersplenism, Splenomegaly, Lymphadenopathy, Increased circulating IgG level, Increased circulat... ORPHA:1304
Nijmegen Breakage Syndrome
Dysgammaglobulinemia OMIM:251260
Spondyloepimetaphyseal Dysplasia, Sponastrime Type
Decreased circulating IgG level OMIM:271510
Lysinuric Protein Intolerance
Hepatosplenomegaly, Decreased circulating antibody level, Abnormality of humoral immunity, Increa... ORPHA:470
Thrombocytopenia-Absent Radius Syndrome
Hepatosplenomegaly, Decreased circulating antibody level OMIM:274000
Primary Sclerosing Cholangitis
Splenomegaly, Hepatosplenomegaly, Polyclonal elevation of IgM ORPHA:171
Leukocyte Adhesion Deficiency Type Ii
Abnormal isohemagglutinin level ORPHA:99843
Crimean-Congo Hemorrhagic Fever
Splenomegaly, Increased circulating IgG level, Increased circulating IgM level, Lymphadenopathy ORPHA:99827
Yellow Fever
Increased circulating IgM level, Increased circulating interleukin 6 concentration ORPHA:99829
Sponastrime Dysplasia
Decreased circulating antibody level ORPHA:93357
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Decreased circulating IgG level, Secretory IgA deficiency ORPHA:500150
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Asplenia, Decreased circulating antibody level ORPHA:261537
Mowat-Wilson Syndrome
Asplenia, Decreased circulating antibody level ORPHA:2152
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Asplenia, Decreased circulating antibody level ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd207

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd207.

No publications found that use IMPC mice or data for Cd207.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cd207tm189369(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cd207tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd207tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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