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Gene: Ucn2 MGI:2176375

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
urocortin 2
Synonyms:
Ucn-2,  Urocortin II

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ucn2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ucn2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spinocerebellar Ataxia Type 27
Akinesia, Aggressive behavior, Limb ataxia, Gait ataxia, Gait disturbance, Difficulty walking, Tr... ORPHA:98764
Type 1 Diabetes Mellitus
Polydipsia, Diabetes mellitus, Polyphagia OMIM:222100
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Freezing of gait, Akinesia, Unsteady gait, Neuromuscular dysphagia, Falls, Gait imbalance, Loss o... ORPHA:240094
Corticosterone Methyloxidase Type Ii Deficiency
Decreased circulating aldosterone level, Increased circulating 18-hydroxycortisone level, Increas... OMIM:610600
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Acquired Central Diabetes Insipidus
Polydipsia, Diabetes insipidus ORPHA:95626
Hereditary Central Diabetes Insipidus
Polydipsia, Diabetes insipidus ORPHA:30925
Huntington Disease
Oral-pharyngeal dysphagia, Aggressive behavior, Inability to walk, Gait disturbance, Gait imbalan... ORPHA:399
Late-Onset Familial Hypoaldosteronism
Elevated serum 11-deoxycortisol, Decreased circulating aldosterone level, Increased circulating r... ORPHA:556037
Spinocerebellar Ataxia 21
Ataxia, Akinesia, Aggressive behavior, Impulsivity, Limb ataxia, Gait ataxia, Progressive cerebel... OMIM:607454
Early-Onset Familial Hypoaldosteronism
Elevated serum 11-deoxycortisol, Decreased circulating aldosterone level, Increased circulating r... ORPHA:556030
Manganese Poisoning
Akinesia, Aggressive behavior, Hypersexuality, Gait disturbance, Inappropriate laughter, Compulsi... ORPHA:306682
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Decreased serum testosterone concentration, Decreased circulating cortisol level, Precocious pube... ORPHA:90793
Kleine-Levin Syndrome
Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, Agitatio... ORPHA:33543
Central Diabetes Insipidus
Polydipsia, Diabetes insipidus, Anorexia ORPHA:178029
East Syndrome
Salt craving, Ataxia, Inability to walk, Hyperaldosteronism, Increased circulating renin level, D... ORPHA:199343
Brain-Lung-Thyroid Syndrome
Thyroid dysgenesis, Hypoparathyroidism, Thyroid hemiagenesis, Hyperactivity, Ataxia, Abnormal eat... ORPHA:209905
Familial Hyperaldosteronism Type I
Adrenal hyperplasia, Abnormal circulating renin, Dexamethasone-suppressible primary hyperaldoster... ORPHA:403
Perry Syndrome
Inappropriate behavior, Disinhibition, Short stepped shuffling gait, Akinesia OMIM:168605
Hyperaldosteronism, Familial, Type Iii
Polydipsia, Adrenal hyperplasia, Hyperaldosteronism, Decreased circulating renin level OMIM:613677
Pigmented Nodular Adrenocortical Disease, Primary, 1
Increased urinary cortisol level, Decreased circulating dehydroepiandrosterone concentration, Pig... OMIM:610489
Atypical Juvenile Parkinsonism
Akinesia, Inability to walk, Gait ataxia, Shuffling gait, Short stepped shuffling gait ORPHA:391411
Spinocerebellar Ataxia Type 21
Progressive cerebellar ataxia, Akinesia, Gait ataxia ORPHA:98773
Neurodegeneration With Brain Iron Accumulation 5
Akinesia, Aggressive behavior OMIM:300894
Kufor-Rakeb Syndrome
Ataxia, Akinesia, Aggressive behavior, Gait disturbance, Dysphagia OMIM:606693
Secondary Non-Traumatic Avascular Necrosis
Addictive alcohol use, Difficulty walking ORPHA:399180
Pigmented Nodular Adrenocortical Disease, Primary, 2
Pigmented micronodular adrenocortical disease, Paradoxical increased cortisol secretion on dexame... OMIM:610475
Classic Progressive Supranuclear Palsy Syndrome
Impulsivity, Akinesia, Neuromuscular dysphagia, Falls, Gait imbalance ORPHA:240071
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Parkinson Disease 17
Akinesia OMIM:614203
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Ataxia, Akinesia, Gait ataxia, Dysdiadochokinesis, Shuffling gait, Dysphagia ORPHA:247234
Familial Hyperaldosteronism Type Iii
Adrenal hyperplasia, Glucocortocoid-insensitive primary hyperaldosteronism, Abnormal circulating ... ORPHA:251274
Methanol Poisoning
Type I diabetes mellitus, Hyperlipidemia, Addictive alcohol use, Type II diabetes mellitus ORPHA:31825
Apparent Mineralocorticoid Excess
Polydipsia, Decreased circulating aldosterone level, Abnormality of circulating cortisol level, D... ORPHA:320
Cystinosis
Nephrogenic diabetes insipidus, Abnormal repetitive mannerisms, Gait disturbance, Delayed puberty... ORPHA:213
Adrenocortical Carcinoma
Increased urinary cortisol level, Diabetes mellitus, Paradoxical increased cortisol secretion on ... ORPHA:1501
Panhypophysitis
Decreased circulating cortisol level, Polydipsia, Reduced circulating prolactin concentration, Ad... ORPHA:95513
Marchiafava-Bignami Disease
Ataxia, Aggressive behavior, Gait ataxia, Addictive alcohol use, Gait disturbance ORPHA:221074
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Adrenal hyperplasia, Abnormal circulating renin, Athetosis, Hyperaldosteronism, Dexamethasone-sup... ORPHA:369929
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Primary Unilateral Adrenal Hyperplasia
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Adrenal hyperplasia, Decreased... ORPHA:231580
Congenital Myopathy 9A
Akinesia OMIM:618822
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Freezing of gait, Akinesia OMIM:619911
Hereditary Late-Onset Parkinson Disease
Impulsivity, Akinesia, Agitation, Shuffling gait, Dysphagia ORPHA:411602
Pediatric-Onset Graves Disease
Hyperactivity, Puberty and gonadal disorders, Thyrotoxicosis with diffuse goiter, Increased circu... ORPHA:525731
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Salt craving, Ataxia, Dysdiadochokinesis, Hyperaldosteronism, Increased circulating renin level, ... OMIM:612780
Corticobasal Syndrome
Gait disturbance, Akinesia ORPHA:454887
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
46,Xy Difference Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Hypergonadotropic hypogonadism, Elevated circulating luteinizing hormone level, Absence of second... ORPHA:90796
Familial Cold Urticaria
Polydipsia ORPHA:47045
Postencephalitic Parkinsonism
Akinesia, Dysphagia ORPHA:97349
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Teratoma, Pineal
Polydipsia OMIM:273120
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency
Abnormal circulating pregnenolone concentration, Abnormal response to human chorionic gonadotroph... ORPHA:95699
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia, Diabetes insipidus OMIM:304800
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Nephrogenic diabetes insipidus, Polydipsia OMIM:125800
Neurodegeneration With Brain Iron Accumulation 1
Hyperactivity, Ataxia, Akinesia, Phonic tics, Choreoathetosis, Gait disturbance, Dysphagia, Obses... OMIM:234200
Ochoa Syndrome
Polydipsia ORPHA:2704
Aceruloplasminemia
Diabetes mellitus, Ataxia, Akinesia, Limb ataxia, Gait ataxia ORPHA:48818
Pituitary Dermoid And Epidermoid Cysts
Enlarged pituitary gland, Polydipsia, Neoplasm of the anterior pituitary, Hypogonadism, Hyperpitu... ORPHA:91351
Isolated Osteopoikilosis
Abnormality of the endocrine system, Addictive alcohol use ORPHA:166119
Staphylococcal Necrotizing Pneumonia
Diabetes mellitus, Addictive alcohol use, Increased circulating procalcitonin concentration ORPHA:36238
Mitochondrial Complex I Deficiency, Nuclear Type 28
Choreoathetosis, Akinesia, Truncal ataxia OMIM:618249
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Hypothyroidism, Akinesia OMIM:619147
Septo-Optic Dysplasia Spectrum
Anterior pituitary hypoplasia, Maternal diabetes, Polydipsia, Abnormality of the hypothalamus-pit... ORPHA:3157
Nephrogenic Diabetes Insipidus
Nephrogenic diabetes insipidus, Polydipsia, Anorexia ORPHA:223
Acquired Aneurysmal Subarachnoid Hemorrhage
Hypercholesterolemia, Hypopituitarism, Hypothyroidism, Addictive alcohol use ORPHA:90065
Bardet-Biedl Syndrome 17
Polydipsia, Hypogonadism OMIM:615994
Hyperparathyroidism, Neonatal Severe
Primary hyperparathyroidism, Elevated circulating parathyroid hormone level, Polydipsia OMIM:239200
Congenital Myopathy 12
Akinesia OMIM:612540
Supranuclear Palsy, Progressive, 2
Falls, Gait imbalance, Akinesia, Dysphagia OMIM:609454
Fetal Akinesia Deformation Sequence
Akinesia ORPHA:994
Gaucher Disease, Perinatal Lethal
Akinesia, Dysphagia OMIM:608013
Whipple Disease
Hypothyroidism, Polydipsia, Ataxia, Anorexia ORPHA:3452
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Increased urinary cortisol level, Paradoxical increased cortisol secretion on dexamethasone suppr... ORPHA:189427
Nephronophthisis 4
Polydipsia OMIM:606966
Acute Lung Injury
Addictive alcohol use ORPHA:178320
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Gitelman Syndrome
Salt craving, Ataxia, Increased circulating renin level, Delayed puberty, Polydipsia OMIM:263800
Wolfram Syndrome
Diabetes mellitus, Ataxia, Hypogonadism, Delayed puberty, Male hypogonadism, Polydipsia, Diabetes... ORPHA:3463
Parkinson Disease 23, Autosomal Recessive Early-Onset
Akinesia OMIM:616840
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Rabson-Mendenhall Syndrome
Increased pineal volume, Precocious puberty, Insulin-resistant diabetes mellitus, Fasting hyperin... ORPHA:769
Supranuclear Palsy, Progressive, 1
Falls, Gait imbalance, Akinesia, Dysphagia OMIM:601104
Herpes Simplex Virus Encephalitis
Addictive alcohol use ORPHA:1930
Nephronophthisis 3
Polydipsia OMIM:604387
Helix Syndrome
Hyperparathyroidism, Polydipsia OMIM:617671
Nephronophthisis 1
Polydipsia OMIM:256100
Acute Promyelocytic Leukemia
Addictive alcohol use, Anorexia ORPHA:520
Hyperparathyroidism-Jaw Tumor Syndrome
Primary hyperparathyroidism, Abnormal parathyroid morphology, Elevated circulating parathyroid ho... ORPHA:99880
Dpagt1-Cdg
Ataxia, Akinesia, Aggressive behavior, Inability to walk, Head-banging, Stereotypical body rocking ORPHA:86309
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Decreased response to growth hormone stimulation test, Central diabetes insipidus, Aggressive beh... ORPHA:293987
Parathyroid Carcinoma
Primary hyperparathyroidism, Abnormal parathyroid morphology, Elevated circulating parathyroid ho... ORPHA:143
Erdheim-Chester Disease
Ataxia, Hypogonadotropic hypogonadism, Xanthelasma, Polydipsia, Diabetes insipidus ORPHA:35687
Hypomagnesemia 3, Renal
Polydipsia, Elevated circulating parathyroid hormone level OMIM:248250
African Trypanosomiasis
Akinesia, Aggressive behavior, Abnormality of the endocrine system, Abnormality of renin-angioten... ORPHA:3385
Nephronophthisis 11
Polydipsia OMIM:613550
Porphyria Cutanea Tarda
Diabetes mellitus, Addictive alcohol use ORPHA:101330
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Renal Hypoplasia
Polydipsia ORPHA:93101
Senior-Boichis Syndrome
Polydipsia, Agitation, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:84081
Arthrogryposis Multiplex Congenita 5
Akinesia OMIM:618947
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Abnormality of endocrine pancreas physiology, Polydipsia, Diabetes mellitus, Hypothyroidism ORPHA:93111
Gitelman Syndrome
Salt craving, Maternal diabetes, Diabetic ketoacidosis, Type I diabetes mellitus, Type II diabete... ORPHA:358
Cirrhotic Cardiomyopathy
Addictive alcohol use ORPHA:57777
Ethylene Glycol Poisoning
Addictive alcohol use, Ataxia ORPHA:31826
Infantile Nephropathic Cystinosis
Polydipsia, Abnormality of thyroid physiology ORPHA:411629
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia, Hyperaldosteronism OMIM:602522
Oligomeganephronia
Polydipsia ORPHA:2260
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Cystinosis, Nephropathic
Diabetes mellitus, Oral-pharyngeal dysphagia, Dysphagia, Primary hypothyroidism, Delayed puberty,... OMIM:219800
Arima Syndrome
Polydipsia, Ataxia OMIM:243910
Juvenile Nephropathic Cystinosis
Polydipsia, Hypothyroidism ORPHA:411634
Cushing Syndrome Due To Ectopic Acth Secretion
Increased urinary cortisol level, Adrenal hyperplasia, Diabetes mellitus, Paradoxical increased c... ORPHA:99889
Bartter Syndrome, Type 2, Antenatal
Polydipsia, Hyperactive renin-angiotensin system, Hyperaldosteronism, Increased circulating renin... OMIM:241200
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Cushing Disease
Increased urinary cortisol level, Adrenal hyperplasia, Diabetes mellitus, Paradoxical increased c... ORPHA:96253
Proximal Renal Tubular Acidosis
Polydipsia ORPHA:47159
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ucn2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ucn2.

No publications found that use IMPC mice or data for Ucn2.

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