Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Dclre1b by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Dyskeratosis Congenita, Autosomal Recessive 8 | Intrauterine growth retardation | OMIM:620133 |
The table below shows human diseases predicted to be associated to Dclre1b by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Granulomas, Congenital Cerebral | Neonatal death | OMIM:306300 | |
Genitourinary Tract Anomalies | Neonatal death | OMIM:305690 | |
Lethal Congenital Contracture Syndrome 3 | Neonatal death | OMIM:611369 | |
Pulmonary Hypoplasia, Primary | Neonatal death | OMIM:265430 | |
Hernia, Anterior Diaphragmatic | Neonatal death | OMIM:306950 | |
Epidermolysis Bullosa With Diaphragmatic Hernia | Neonatal death | OMIM:226735 | |
Pyknoachondrogenesis | Stillbirth | OMIM:265880 | |
Mitochondrial Complex I Deficiency, Nuclear Type 30 | Neonatal death, Intrauterine growth retardation | OMIM:301021 | |
Neutropenia, Lethal Congenital, With Eosinophilia | Neonatal death | OMIM:257100 | |
Thanatophoric Dysplasia, Glasgow Variant | Neonatal death | OMIM:273680 | |
Stuve-Wiedemann Syndrome 2 | Neonatal death, Intrauterine growth retardation, Stillbirth, Death in adolescence | OMIM:619751 | |
Lethal Congenital Contracture Syndrome 8 | Neonatal death, Death in infancy | OMIM:616287 | |
Immunoneurologic Disorder, X-Linked | Neonatal death | OMIM:300076 | |
Mitochondrial Dna Depletion Syndrome 12A (Cardiomyopathic Type), Autosomal Dominant | Neonatal death, Death in infancy | OMIM:617184 | |
Congenital Myopathy 2B, Severe Infantile, Autosomal Recessive | Neonatal death, Death in infancy, Death in childhood | OMIM:620265 | |
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4B | Neonatal death | OMIM:615228 | |
Combined Oxidative Phosphorylation Deficiency 8 | Neonatal death, Death in infancy, Death in childhood | OMIM:614096 | |
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia | Neonatal death | OMIM:612138 | |
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies | Neonatal death | OMIM:619602 | |
Ichthyosis, Congenital, Autosomal Recessive 4B | Neonatal death, Death in infancy | OMIM:242500 | |
Mitochondrial Complex I Deficiency, Nuclear Type 35 | Neonatal death, Intrauterine growth retardation | OMIM:619003 | |
Lung Agenesis, Congenital Heart Defects, And Thumb Anomalies Syndrome | Neonatal death | OMIM:601612 | |
Cardiomyopathy, Dilated, 2H | Neonatal death | OMIM:620203 | |
Arthrogryposis Multiplex Congenita 6 | Neonatal death, Death in infancy, Death in childhood | OMIM:619334 | |
Combined Oxidative Phosphorylation Deficiency 21 | Neonatal death | OMIM:615918 | |
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts | Neonatal death, Death in infancy | OMIM:613730 | |
Larsen-Like Syndrome, Lethal Type | Neonatal death | OMIM:245650 | |
Ulnar Agenesis And Endocardial Fibroelastosis | Neonatal death | OMIM:276822 | |
Fanconi Anemia, Complementation Group O | Neonatal death, Death in infancy, Miscarriage | OMIM:613390 | |
Medium Chain 3-Ketoacyl-Coa Thiolase Deficiency | Neonatal death | OMIM:602199 | |
Combined Oxidative Phosphorylation Deficiency 40 | Neonatal death, Intrauterine growth retardation, Death in infancy | OMIM:618835 | |
Combined Oxidative Phosphorylation Deficiency 42 | Neonatal death, Intrauterine growth retardation, Death in infancy | OMIM:618839 | |
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia | Neonatal death | OMIM:619817 | |
Fetal Gaucher Disease | Neonatal death, Death in infancy, Stillbirth | ORPHA:85212 | |
Afibrinogenemia, Congenital | Neonatal death, Death in infancy, Death in adolescence, Death in childhood | OMIM:202400 | |
Mitochondrial Complex I Deficiency, Nuclear Type 9 | Neonatal death | OMIM:618232 | |
Boomerang Dysplasia | Neonatal death | OMIM:112310 | |
Lymphatic Malformation 12 | Neonatal death, Death in adolescence | OMIM:620014 | |
Lethal Congenital Contracture Syndrome 1 | Neonatal death | OMIM:253310 | |
Abcd Syndrome | Neonatal death | OMIM:600501 | |
Mednik Syndrome | Neonatal death, Death in infancy, Death in childhood | OMIM:609313 | |
Sacral Agenesis With Vertebral Anomalies | Neonatal death | OMIM:615709 | |
Surfactant Metabolism Dysfunction, Pulmonary, 1 | Neonatal death, Death in infancy | OMIM:265120 | |
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3 | Neonatal death | OMIM:619362 | |
Dyskeratosis Congenita, Autosomal Recessive 8 | Intrauterine growth retardation | OMIM:620133 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Dclre1btm214409(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors |
Dclre1btm459024(L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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