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Gene: Dclre1b MGI:2156057

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
DNA cross-link repair 1B
Synonyms:
mSNM1B,  SNMIB,  Apollo

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dclre1b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dclre1b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Dyskeratosis Congenita, Autosomal Recessive 8
Intrauterine growth retardation OMIM:620133

The table below shows human diseases predicted to be associated to Dclre1b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Lethal Congenital Contracture Syndrome 3
Neonatal death OMIM:611369
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Pyknoachondrogenesis
Stillbirth OMIM:265880
Mitochondrial Complex I Deficiency, Nuclear Type 30
Neonatal death, Intrauterine growth retardation OMIM:301021
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death OMIM:273680
Stuve-Wiedemann Syndrome 2
Neonatal death, Intrauterine growth retardation, Stillbirth, Death in adolescence OMIM:619751
Lethal Congenital Contracture Syndrome 8
Neonatal death, Death in infancy OMIM:616287
Immunoneurologic Disorder, X-Linked
Neonatal death OMIM:300076
Mitochondrial Dna Depletion Syndrome 12A (Cardiomyopathic Type), Autosomal Dominant
Neonatal death, Death in infancy OMIM:617184
Congenital Myopathy 2B, Severe Infantile, Autosomal Recessive
Neonatal death, Death in infancy, Death in childhood OMIM:620265
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 4B
Neonatal death OMIM:615228
Combined Oxidative Phosphorylation Deficiency 8
Neonatal death, Death in infancy, Death in childhood OMIM:614096
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Neonatal death OMIM:612138
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies
Neonatal death OMIM:619602
Ichthyosis, Congenital, Autosomal Recessive 4B
Neonatal death, Death in infancy OMIM:242500
Mitochondrial Complex I Deficiency, Nuclear Type 35
Neonatal death, Intrauterine growth retardation OMIM:619003
Lung Agenesis, Congenital Heart Defects, And Thumb Anomalies Syndrome
Neonatal death OMIM:601612
Cardiomyopathy, Dilated, 2H
Neonatal death OMIM:620203
Arthrogryposis Multiplex Congenita 6
Neonatal death, Death in infancy, Death in childhood OMIM:619334
Combined Oxidative Phosphorylation Deficiency 21
Neonatal death OMIM:615918
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts
Neonatal death, Death in infancy OMIM:613730
Larsen-Like Syndrome, Lethal Type
Neonatal death OMIM:245650
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death OMIM:276822
Fanconi Anemia, Complementation Group O
Neonatal death, Death in infancy, Miscarriage OMIM:613390
Medium Chain 3-Ketoacyl-Coa Thiolase Deficiency
Neonatal death OMIM:602199
Combined Oxidative Phosphorylation Deficiency 40
Neonatal death, Intrauterine growth retardation, Death in infancy OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Neonatal death, Intrauterine growth retardation, Death in infancy OMIM:618839
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Neonatal death OMIM:619817
Fetal Gaucher Disease
Neonatal death, Death in infancy, Stillbirth ORPHA:85212
Afibrinogenemia, Congenital
Neonatal death, Death in infancy, Death in adolescence, Death in childhood OMIM:202400
Mitochondrial Complex I Deficiency, Nuclear Type 9
Neonatal death OMIM:618232
Boomerang Dysplasia
Neonatal death OMIM:112310
Lymphatic Malformation 12
Neonatal death, Death in adolescence OMIM:620014
Lethal Congenital Contracture Syndrome 1
Neonatal death OMIM:253310
Abcd Syndrome
Neonatal death OMIM:600501
Mednik Syndrome
Neonatal death, Death in infancy, Death in childhood OMIM:609313
Sacral Agenesis With Vertebral Anomalies
Neonatal death OMIM:615709
Surfactant Metabolism Dysfunction, Pulmonary, 1
Neonatal death, Death in infancy OMIM:265120
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Neonatal death OMIM:619362
Dyskeratosis Congenita, Autosomal Recessive 8
Intrauterine growth retardation OMIM:620133

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dclre1b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dclre1b.

No publications found that use IMPC mice or data for Dclre1b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Dclre1btm214409(L1L2_Bact_P) Reporter-tagged deletion allele (with selection cassette) Targeting vectors
Dclre1btm459024(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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