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Gene: Trim66 MGI:2152406

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Gene Summary

Name:
tripartite motif-containing 66
Synonyms:
Tif1d,  D7H11orf29

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Trim66tm1a(EUCOMM)Wtsi HOM Early adult 1.37×10-06
increased heart weight Trim66tm1a(EUCOMM)Wtsi HOM Early adult 5.69×10-07
decreased body weight Trim66tm1a(EUCOMM)Wtsi HOM Early adult 5.77×10-05
increased exploration in new environment Trim66tm1a(EUCOMM)Wtsi HOM Early adult 2.90×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Trim66tm1a(EUCOMM)Wtsi
body, HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
head, HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
head, HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
head, HOM, Female, WTSI
Trim66tm1a(EUCOMM)Wtsi
forearm, HOM, Female, WTSI

View all 85 images

Trim66tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
anterior commissure, decreased anterior commissure size, HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
anterior commissure, decreased anterior commissure size, HOM, Male, WTSI

View all 8 images

Trim66tm1a(EUCOMM)Wtsi
eye, abnormal retinal pigmentation, HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
abnormal retinal pigmentation, HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
abnormal retinal pigmentation, HOM, Male, WTSI
Trim66tm1a(EUCOMM)Wtsi
eye, abnormal retinal pigmentation, HOM, Female, WTSI
Trim66tm1a(EUCOMM)Wtsi
eye, abnormal retinal pigmentation, HOM, Female, WTSI

View all 6 images

Human diseases caused by Trim66 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Trim66 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ethanolaminosis
Cardiomegaly OMIM:227150
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity, Cardiomegaly ORPHA:88643
Mitochondrial Complex I Deficiency, Nuclear Type 39
Small for gestational age, Cardiomegaly, Perimembranous ventricular septal defect, Atrial septal ... OMIM:620135
Congenitally Uncorrected Transposition Of The Great Arteries
Levotransposition of the great arteries, Hepatomegaly, Small for gestational age, Ventricular sep... ORPHA:860
Congenital Tricuspid Valve Dysplasia
Hepatomegaly, Small for gestational age, Cardiomegaly, Pericardial effusion, Anomalous pulmonary ... ORPHA:555874
Double Outlet Left Ventricle
Double outlet left ventricle, Ventricular septal defect, Cardiomegaly, Bicuspid pulmonary valve, ... ORPHA:3427

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trim66

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trim66.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Trim66tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Trim66tm1a(EUCOMM)Wtsi PMC6459510
Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mammalian genome : official journal of the International Mammalian Genome Society (August 2013) Trim66tm2a(EUCOMM)Wtsi Trim66tm1a(EUCOMM)Wtsi PMC3745610

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Trim66tm47408(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Trim66tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Trim66tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Trim66tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Trim66tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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