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Gene: Akr1c20 MGI:2151104

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Gene Summary

Name:
aldo-keto reductase family 1, member C20
Synonyms:
2610528B18Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Akr1c20tm1a(KOMP)Wtsi
head, snout, abnormal snout morphology, HOM, Male, WTSI
Akr1c20tm1a(KOMP)Wtsi
snout, head, asymmetric snout, abnormal snout morphology, HOM, Male, WTSI
Akr1c20tm1a(KOMP)Wtsi
head, snout, asymmetric snout, abnormal snout morphology, HOM, Male, WTSI
Akr1c20tm1a(KOMP)Wtsi
head, upturned snout, abnormal snout morphology, abnormal snout morphology, snout, HOM, Female, WTSI
Akr1c20tm1a(KOMP)Wtsi
head, asymmetric snout, malocclusion, snout, abnormal snout morphology, HOM, Female, WTSI

View all 6 images

Human diseases caused by Akr1c20 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Akr1c20 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
46,Xy Sex Reversal 8
OMIM:614279

The table below shows human diseases predicted to be associated to Akr1c20 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
46,Xy Sex Reversal 8
OMIM:614279

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Akr1c20

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Akr1c20.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Akr1c20tm1a(KOMP)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Akr1c20tm1a(KOMP)Wtsi PMC6671969
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Akr1c20tm1a(KOMP)Wtsi PMC5827107

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Akr1c20tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Akr1c20tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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