Gene: Slc5a5

Name solute carrier family 5 (sodium iodide symporter), member 5

Synonyms NIS

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2149330   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Slc5a5

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Slc5a5 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal sleep behavior Slc5a5tm1b(KOMP)Wtsi HOM Female Male postnatal 5.74E-7
increased body length Slc5a5tm1b(KOMP)Wtsi HOM Male postnatal 1.81E-5
decreased bone mineral density Slc5a5tm1b(KOMP)Wtsi HOM Female postnatal 2.4E-5
decreased urine creatinine level Slc5a5tm1b(KOMP)Wtsi HOM Female Male postnatal 2.51E-5
prolonged QRS complex duration Slc5a5tm1b(KOMP)Wtsi HOM Female Male postnatal 3.38E-5
decreased exploration in new environment Slc5a5tm1b(KOMP)Wtsi HOM Male postnatal 8.95E-5
decreased prepulse inhibition Slc5a5tm1b(KOMP)Wtsi HOM Female Male postnatal 9.88E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354)
Aorta 2 No (2/530)
Brain 2 No (8/530)
Brainstem 2 No (5/530)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530)
Cerebellum 2 No (6/530)
Cerebral cortex 2 No (6/530)
Epididymis 2 No (1/103)
Esophagus 2 No (1/354)
Eye 2 No (1/530)
Heart 2 No (4/530)
Hippocampus 2 No (7/530)
Hypothalamus 2 No (5/529)
Kidney 2 No (13/530)
Large intestine 2 No (7/530)
Liver 2 No
Lower urinary tract 2 No (3/530)
Lung 2 No (4/530)
Lymph node 2 No (2/530)
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No (3/354)
Ovary 2 No (1/530)
Oviduct 2 No (1/530)
Pancreas 2 No (2/530)
Peripheral nervous system 2 No (4/530)
Peyer's patch 2 No (1/354)
Pituitary gland 2 No (2/530)
Prostate gland 2 No (3/530)
Skeletal muscle 2 No
Skin 2 No (2/530)
Small intestine 2 No (5/530)
Spinal cord 2 No (5/530)
Spleen 2 No (3/530)
Stomach 2 No (5/530)
Striatum 2 No (6/530)
Submandibular gland 2 No
Testis 2 No (7/530) (1/2)
Thalamus 2 No
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530)
Trachea 2 No (5/530)
Urinary bladder 2 No
Uterus 2 No (1/530)
Vascular system 2 No (1/354)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    reproductive system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (5/413)
Dorsal root ganglion 2 No Data
Ear 2
Embryo 2
Eye 2
Foot 2
Forebrain 2
Forelimb 2
Fronto-nasal process 2
Hand 2
Head 2 (4/413)
Heart 2
Hindbrain 2 (5/413)
Hindlimb 2
Liver 2
Lung 2
Mandibular process 2
Maxillary process 2
Midbrain 2
Nose 2 No Data
Oral cavity 2
Skin 2
Spinal cord 2 No Data
Tail 2
Tail somite 2


Associated Images

Associated Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Slc5a5tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Slc5a5tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Slc5a5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene