Gene: Afap1l2

Order

Name actin filament associated protein 1-like 2

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:2147658    Ensembl Gene    Ensembl Orthologs    My Genes   

Phenotype associations for Afap1l2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Afap1l2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal spleen morphology Afap1l2tm1b(KOMP)Wtsi HOM Female postnatal 0.0
abnormal coat/ hair morphology Afap1l2tm1b(KOMP)Wtsi HOM Male postnatal 5.53E-13
decreased total body fat amount Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.36E-8
improved glucose tolerance Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.89E-7
decreased circulating insulin level Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.34E-6
hypoactivity Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 9.67E-6
increased lean body mass Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.57E-5
increased circulating alkaline phosphatase level Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 6.6E-5
abnormal behavior Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 7.9E-5
prolonged RR interval Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 8.43E-5
long tibia Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 9.19E-5
decreased heart rate Afap1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 9.32E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415) (2/4)
Aorta 4 No
Blood 4 No
Bone marrow 4 No
Brain 4 No (2/4)
Brainstem 4 No
Brown adipose tissue 4 No (2/4)
Cartilage tissue 4 No
Cecum 4 No (12/383) (2/4)
Cerebellum 4 No (4/4)
Cerebral cortex 4 No
Chest bone 4 No (2/4)
Colon 4 No (12/127) (2/4)
Diaphragm 4 No (1/4)
Duodenum 4 No (2/127) (2/4)
Epididymis 4 No (18/134) (2/4)
Esophagus 4 No (7/415) (4/4)
Eye 4 No (1/4)
Gall bladder 4 No
Gonadal fat pad 4 No (1/4)
Harderian gland 4 No (2/4)
Heart 4 No
Hindlimb 4 No
Hippocampus 4 No
Hypothalamus 4 No
Ileum 4 No (14/127) (4/4)
Jejunum 4 No (6/127) (2/4)
Kidney 4 No (18/584) (4/4)
Large intestine 4 No (10/584)
Liver 4 No
Lower urinary tract 4 No
Lung 4 No
Lymph node 4 No
Mammary gland 4 No
Mesenteric lymph node 4 No (2/4)
Mesenteric adipose tissue 4 No (3/4)
Midbrain 4 No (4/4)
Olfactory lobe 4 No (3/4)
Ovary 4 No (1/584) (1/4)
Oviduct 4 No (1/4)
Pancreas 4 No (5/584) (2/4)
Parathyroid gland 4 No
Parotid gland 4 No
Penis 4 No (2/4)
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No
Prostate gland 4 No (12/584) (1/4)
Quadriceps 4 No (3/4)
Sciatic nerve 4 No (4/4)
Skeletal muscle 4 No
Skin 4 No (4/4)
Small intestine 4 No (9/584)
Spinal cord 4 No (4/4)
Spleen 4 No (2/584) (3/4)
Stomach 4 No (12/584) (4/4)
Stomach pyloric region 4 No
Striatum 4 No
Sublingual gland 4 No
Submandibular gland 4 No (2/132) (1/4)
Testis 4 No (2/584) (2/4)
Thymus 4 No (2/4)
Thyroid gland 4 No (15/584) (4/4)
Tongue 4 No (5/127) (4/4)
Trachea 4 No (3/4)
Trigeminal V nerve 4 No (2/4)
Urinary bladder 4 No (4/4)
Uterus 4 No (2/4)
Vagina 4 No (1/4)
Vas deferens 4 No (15/388) (2/4)
Vascular system 4 No
Vesicular gland 4 No (2/4)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system limb respiratory system digestive system set of connective tissues reproductive system adipose tissue musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    40 Images
  • X-ray: XRay Images Lateral Orientation
    20 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Afap1l2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Afap1l2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene