Gene: Wsb2

Name WD repeat and SOCS box-containing 2

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2144041   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Wsb2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Wsb2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
female infertility Wsb2tm1b(EUCOMM)Hmgu HOM Female postpartum stage 0.0
male infertility Wsb2tm1b(EUCOMM)Hmgu HOM Male postpartum stage 0.0
decreased respiratory quotient Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.48E-16
decreased food intake Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.9E-11
decreased vertical activity Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 6.14E-9
decreased heart rate Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.34E-7
hyperactivity Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.17E-7
decreased total retina thickness Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.1E-6
abnormal retinal vasculature morphology Wsb2tm1b(EUCOMM)Hmgu HOM Female postnatal 1.19E-6
abnormal retinal blood vessel morphology Wsb2tm1b(EUCOMM)Hmgu HOM Female postnatal 3.42E-6
decreased cardiac muscle contractility Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.17E-5
dilated heart left ventricle Wsb2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.01E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Blood 2 No
Bone 2 No (1/539)
Bone marrow 2 No
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cecum 2 No (1/355)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Chest bone 2 No (2/2)
Colon 2 No (1/99)
Cranium 2 No
Diaphragm 2 No
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562) (1/2)
Gall bladder 2 No
Harderian gland 2 No
Heart 2 No (3/562)
Hindlimb 2 No
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562)
Main olfactory bulb 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No
Olfactory lobe 2 No (4/393)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Parotid gland 2 No
Penis 2 No
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Sciatic nerve 2 No
Skeletal muscle 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Stomach pyloric region 2 No
Striatum 2 No (4/562)
Sublingual gland 2 No
Submandibular gland 2 No (1/104)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Tongue 2 No
Trachea 2 No (3/562)
Trigeminal V nerve 2 No
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562)
Vagina 2 No
Vas deferens 2 No (1/360)
Vascular system 2 No (1/393)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    digestive system
    nervous system
    sensory organ
    reproductive system
    musculoskeletal system
    integumental system
    trunk
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Wholemount
    24 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Wsb2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Wsb2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Wsb2tm44148(L1L2_gt2)
Vector
Gene