Gene: Tmem189

Order

Name transmembrane protein 189

Status ES CellsMice
tm1a
phenotype data available

Links MGI:2142624    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Tmem189

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Tmem189 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased T cell number Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 1.31E-15
decreased bone mineral content Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 1.75E-13
decreased CD8-positive, alpha-beta T cell number Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 3.88E-13
decreased lean body mass Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 5.97E-13
decreased bone mineral density Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 7.63E-13
decreased erythrocyte cell number Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 1.83E-12
decreased hemoglobin content Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 3.28E-11
abnormal bone structure Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 3.51E-11
increased mean platelet volume Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 6.11E-11
decreased hematocrit Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 7.76E-11
decreased circulating calcium level Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 2.04E-9
decreased circulating total protein level Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 5.88E-8
decreased CD4-positive, alpha beta T cell number Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 2.63E-7
abnormal incisor color Tmem189tm1a(KOMP)Wtsi HOM Female postnatal 3.09E-7
decreased total body fat amount Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 1.23E-6
increased mean corpuscular volume Tmem189tm1a(KOMP)Wtsi HOM Female postnatal 2.74E-6
increased B cell number Tmem189tm1a(KOMP)Wtsi HOM Male postnatal 1.38E-5
decreased circulating thyroxine level Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 2.06E-5
impaired glucose tolerance Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 3.14E-5
increased circulating magnesium level Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 3.6E-5
decreased grip strength Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 7.19E-5
increased circulating potassium level Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 8.96E-5
increased circulating LDL cholesterol level Tmem189tm1a(KOMP)Wtsi HOM Female Male postnatal 9.99E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No (1/2)
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse digestive system cardiovascular system nervous system reproductive system integumental system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (8)
  • Tmem189tm1a(KOMP)Wtsi
    HEART, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    OVARY, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    LIVER, HET, Male, WTSI

show all 8 images

nervous system (7)
  • Tmem189tm1a(KOMP)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI

show all 7 images

endocrine system (2)
  • Tmem189tm1a(KOMP)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    THYROID GLAND, HET, Female, WTSI
reproductive system (2)
  • Tmem189tm1a(KOMP)Wtsi
    OVARY, HET, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
cardiovascular system (1)
  • Tmem189tm1a(KOMP)Wtsi
    HEART, HET, Female, WTSI
digestive system (1)
  • Tmem189tm1a(KOMP)Wtsi
    LIVER, HET, Male, WTSI
integumental system (1)
  • Tmem189tm1a(KOMP)Wtsi
    AURICLE, SKIN, HET, Female, WTSI
respiratory system (1)
  • Tmem189tm1a(KOMP)Wtsi
    LUNG, HET, Female, WTSI
sensory organ (1)
  • Tmem189tm1a(KOMP)Wtsi
    AURICLE, SKIN, HET, Female, WTSI
urinary system (1)
  • Tmem189tm1a(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    38 Images
  • X-ray: XRay Images Lateral Orientation
    27 Images
  • X-ray: XRay Images Forepaw
    11 Images
  • X-ray: XRay Images Skull Lateral Orientation
    13 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
Legacy Phenotype Associated Images
Xray (125)
  • Tmem189tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    WT, Male, WTSI

show all 125 images

Eye Morphology (21)
  • Tmem189tm1a(KOMP)Wtsi
    EYE, abnormal retinal pigmentation, HOM, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    EYE, abnormal retinal pigmentation, HOM, Male, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    EYE, abnormal retinal pigmentation, HOM, Male, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    EYE, abnormal retinal pigmentation, HOM, Male, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    EYE, abnormal retinal pigmentation, HOM, Female, WTSI

show all 21 images

Skin Histopathology (2)
  • Tmem189tm1a(KOMP)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI
  • Tmem189tm1a(KOMP)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Tmem189tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Tmem189tm35635(L1L2_Pgk_P)
Vector
Gene
Tmem189tm361668(L1L2_Bact_P)
Vector
Gene