Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Cadm3 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Charcot-Marie-Tooth Disease, Axonal, Type 2Ff | OMIM:619519 |
The table below shows human diseases predicted to be associated to Cadm3 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Guillain-Barre Syndrome, Familial | Acute demyelinating polyneuropathy | OMIM:139393 | |
Neuropathy, Hereditary Sensory, X-Linked | Decreased number of peripheral myelinated nerve fibers | OMIM:310470 | |
Pelizaeus-Merzbacher disease | Abnormal CNS myelination, Leukodystrophy | DECIPHER:38 | |
Intellectual Developmental Disorder, Autosomal Recessive 4 | Delayed myelination | OMIM:611107 | |
Autosomal Recessive Spastic Paraplegia Type 71 | Abnormal myelination | ORPHA:401840 | |
Slowed Nerve Conduction Velocity, Autosomal Dominant | Onion bulb formation, Peripheral demyelination | OMIM:608236 | |
Adult-onset autosomal dominant leukodystrophy (ADLD) | Peripheral demyelination, Leukodystrophy | DECIPHER:59 | |
Autosomal Recessive Spastic Paraplegia Type 70 | Abnormal myelination | ORPHA:401835 | |
Autosomal Recessive Spastic Paraplegia Type 57 | Abnormal myelination | ORPHA:431329 | |
Autosomal Recessive Spastic Paraplegia Type 69 | Abnormal myelination | ORPHA:401830 | |
Autosomal Recessive Spastic Paraplegia Type 67 | Abnormal myelination | ORPHA:401820 | |
Infantile Osteopetrosis With Neuroaxonal Dysplasia | Abnormal myelination | ORPHA:85179 | |
Cobblestone Lissencephaly Without Muscular Or Ocular Involvement | Abnormal myelination | ORPHA:352682 | |
Early-Onset Epileptic Encephalopathy And Intellectual Disability Due To Grin2A Mutation | Abnormal myelination | ORPHA:289266 | |
Intellectual Developmental Disorder With Dysmorphic Facies And Ptosis | Abnormal myelination | OMIM:617333 | |
Pelizaeus-Merzbacher Disease, Connatal Form | Cerebral hypomyelination, Abnormal myelination | ORPHA:280210 | |
Non-Specific Early-Onset Epileptic Encephalopathy | Abnormal myelination | ORPHA:442835 | |
X-Linked Intellectual Disability With Isolated Growth Hormone Deficiency | Abnormal myelination | ORPHA:67045 | |
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2Z | Mixed demyelinating and axonal polyneuropathy, Abnormal peripheral myelination, Abnormal myelination | ORPHA:466768 | |
Monosomy 18Q | Abnormal myelination | ORPHA:1600 | |
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome | Delayed myelination, Abnormal myelination | ORPHA:404454 | |
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome | Abnormal myelination | ORPHA:309854 | |
Cockayne Syndrome Type 3 | Demyelinating peripheral neuropathy, Abnormal myelination | ORPHA:90324 | |
Degcags Syndrome | Abnormal myelination | OMIM:619488 | |
Orofaciodigital Syndrome Type 14 | Abnormal myelination | ORPHA:434179 | |
Charcot-Marie-Tooth Disease, Axonal, Type 2Ff | OMIM:619519 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Cadm3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Cadm3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Cadm3tm2e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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