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Gene: Cyp4x1 MGI:1932403

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cytochrome P450, family 4, subfamily x, polypeptide 1
Synonyms:
Cyp4a28-ps

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cyp4x1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cyp4x1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity
Increased waist to hip ratio, Obesity, Decreased resting energy expenditure OMIM:601665
Maturity-Onset Diabetes Of The Young, Type 11
Overweight, Obesity OMIM:613375
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Severe Intellectual Disability-Hypotonia-Strabismus-Coarse Face-Planovalgus Syndrome
Gait disturbance, Obesity ORPHA:436141
Adiposis Dolorosa
Obesity, Painful subcutaneous lipomas OMIM:103200
Obesity Due To Melanocortin 4 Receptor Deficiency
Childhood-onset truncal obesity, Obesity, Increased adipose tissue ORPHA:71529
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Simpson-Golabi-Behmel Syndrome, Type 2
Inguinal hernia, Obesity OMIM:300209
X-Linked Intellectual Disability-Hypogonadism-Ichthyosis-Obesity-Short Stature Syndrome
Hernia of the abdominal wall, Obesity ORPHA:3055
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Obesity Due To Prohormone Convertase I Deficiency
Failure to thrive, Childhood-onset truncal obesity, Obesity, Increased adipose tissue ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Failure to thrive, Childhood-onset truncal obesity, Obesity, Increased adipose tissue ORPHA:71526
Hypothyroidism, Congenital, Nongoitrous, 6
Omphalocele, Increased body mass index, Broad-based gait, Increased body weight OMIM:614450
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Truncal obesity, Obesity, Large for gestational age OMIM:240900
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Autism, Susceptibility To, X-Linked 6
Obesity OMIM:300872
Summitt Syndrome
Obesity OMIM:272350
Obesity-Hypoventilation Syndrome
Cyanosis, Obesity OMIM:257500
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Body Mass Index Quantitative Trait Locus 20
Obesity, Tall stature OMIM:618406
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Obesity And Hypopigmentation
Overgrowth, Obesity OMIM:620195
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Lethargy, Increased body weight ORPHA:276608
Bardet-Biedl Syndrome 22
Obesity, Large for gestational age OMIM:617119
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor
Umbilical hernia, Inguinal hernia, Overgrowth, Large for gestational age OMIM:618272
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Gait disturbance, Increased body weight ORPHA:589905
Joubert Syndrome 32
Ataxia, Tall stature, Large for gestational age OMIM:617757
Laurence-Moon Syndrome
Ataxia, Obesity OMIM:245800
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity ORPHA:88643
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Omphalocele, Small for gestational age, Large for gestational age, Overgrowth, Umbilical hernia ORPHA:254534
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy
Waddling gait, Lipodystrophy, Achilles tendon contracture, Elbow flexion contracture, Obesity, De... ORPHA:98855
Congenital Myopathy 9A
Obesity, Akinesia OMIM:618822
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Pigmented Nodular Adrenocortical Disease, Primary, 4
Dorsocervical fat pad, Increased body weight OMIM:615830
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Hypogonadotropic Hypogonadism 27 Without Anosmia
Obesity OMIM:619755
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Small for gestational age, Increased body weight OMIM:274300
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Lethargy, Increased body weight, Large for gestational age ORPHA:263455
Congenital Analbuminemia
Small for gestational age, Lipodystrophy, Obesity ORPHA:86816
Insulinoma
Lethargy, Increased body weight ORPHA:97279
Wilson Disease
Failure to thrive, Increased body weight, Difficulty walking, Weight loss ORPHA:905
Acth-Independent Macronodular Adrenal Hyperplasia 2
Abdominal obesity, Increased body weight OMIM:615954
Blue Diaper Syndrome
Increased body weight ORPHA:94086
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Abdominal obesity, Dorsocervical fat pad, Increased body weight ORPHA:189427
Magel2-Related Prader-Willi-Like Syndrome
Flexion contracture, Increased body weight, Abdominal obesity, Lethargy, Failure to thrive ORPHA:398069
Sotos Syndrome
Overgrowth, Increased body weight, Tall stature OMIM:117550
Joubert Syndrome 39
Overweight, Joint contracture of the 5th finger OMIM:619562
Adrenocortical Carcinoma
Increased body weight, Weight loss ORPHA:1501
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Failure to thrive, Increased body weight ORPHA:264580
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Increased body weight ORPHA:79240
Insulin-Resistance Syndrome Type B
Abnormality of body weight, Decreased body weight, Increased body weight, Weight loss ORPHA:2298
Cushing Disease
Truncal obesity, Abdominal obesity, Dorsocervical fat pad, Increased body weight ORPHA:96253
Hellp Syndrome
Increased body weight ORPHA:244242
Cushing Syndrome Due To Ectopic Acth Secretion
Dorsocervical fat pad, Increased body weight, Weight loss, Truncal obesity, Abdominal obesity ORPHA:99889
Carney Complex
Abdominal obesity, Dorsocervical fat pad, Increased body weight, Tall stature ORPHA:1359

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cyp4x1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cyp4x1.

No publications found that use IMPC mice or data for Cyp4x1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cyp4x1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cyp4x1tm467(L1L2_st0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cyp4x1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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