Gene: Recql4

Order

Name RecQ protein-like 4

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1931028    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Recql4

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Recql4 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Recql4tm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
preweaning lethality, complete penetrance Recql4tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
increased total body fat amount Recql4tm1.1(KOMP)Vlcg HET Male postnatal 7.67E-7
abnormal coat/ hair morphology Recql4tm1.1(KOMP)Vlcg HET Female postnatal 3.49E-6
decreased lean body mass Recql4tm1.1(KOMP)Vlcg HET Male postnatal 1.15E-5
increased aggression Recql4tm1.1(KOMP)Vlcg HET Male postnatal 8.76E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415)
Aorta 4 No
Blood 4 No
Bone marrow 4 No (2/4)
Brain 4 No (2/4)
Brainstem 4 No
Brown adipose tissue 4 No
Cartilage tissue 4 No
Cecum 4 No (12/383) (2/4)
Cerebellum 4 No
Cerebral cortex 4 No
Chest bone 4 No
Colon 4 No (12/127) (2/4)
Diaphragm 4 No
Duodenum 4 No (2/127) (1/4)
Epididymis 4 No (18/134) (2/4)
Esophagus 4 No (7/415)
Eye 4 No
Gall bladder 4 No
Gonadal fat pad 4 No
Harderian gland 4 No (1/4)
Heart 4 No
Hindlimb 4 No
Hippocampus 4 No
Hypothalamus 4 No
Ileum 4 No (14/127) (4/4)
Jejunum 4 No (6/127) (1/4)
Kidney 4 No (18/584) (4/4)
Large intestine 4 No (10/584)
Liver 4 No
Lower urinary tract 4 No
Lung 4 No
Lymph node 4 No
Mammary gland 4 No
Mesenteric lymph node 4 No
Mesenteric adipose tissue 4 No
Midbrain 4 No (2/4)
Olfactory lobe 4 No
Ovary 4 No (1/584)
Oviduct 4 No
Pancreas 4 No (5/584)
Parathyroid gland 4 No
Parotid gland 4 No
Penis 4 No
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No
Prostate gland 4 No (12/584) (1/4)
Quadriceps 4 No
Sciatic nerve 4 No
Skeletal muscle 4 No
Skin 4 No (2/4)
Small intestine 4 No (9/584)
Spinal cord 4 No (3/4)
Spleen 4 No (2/584) (1/4)
Stomach 4 No (12/584) (2/4)
Stomach pyloric region 4 No
Striatum 4 No
Sublingual gland 4 No
Submandibular gland 4 No (2/132) (1/4)
Testis 4 No (2/584) (2/4)
Thymus 4 No
Thyroid gland 4 No (15/584) (2/4)
Tongue 4 No (5/127) (3/4)
Trachea 4 No
Trigeminal V nerve 4 No (1/4)
Urinary bladder 4 No
Uterus 4 No
Vagina 4 No
Vas deferens 4 No (15/388) (2/4)
Vascular system 4 No
Vesicular gland 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system endocrine system digestive system reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2 (1/51)
Brain 8 (6/485) (2/8)
Central nervous system ganglion 2 (1/51)
Ear 8 (1/485)
Embryo 8 (1/485) (2/8)
Eye 8 (1/485)
Foot 8 (1/485)
Forebrain 8 (1/485) (2/8)
Forelimb 8 (1/485)
Gut 2 (1/50)
Hand 8 (1/485)
Head 8 (5/485)
Heart 8 (1/485) (2/8)
Hindbrain 8 (6/485)
Hindlimb 8 (1/485)
Liver 8 (1/485) (2/8)
Lung 8 (1/485)
Mandibular process 8 (1/485)
Maxillary process 8 (1/485)
Midbrain 8 (1/485) (2/8)
Nose 2 (1/51)
Oral cavity 8 (1/485)
Skeleton 2 (1/51)
Skin 8 (1/485)
Spinal cord 2 (1/50)
Tail 8 (1/485)
Tail somite 8 (1/485)
Trachea 2 (1/50)
Urinary system 2 (1/50)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    40 Images
  • X-ray: XRay Images Lateral Orientation
    20 Images
  • Embryo LacZ: LacZ images wholemount
    24 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Recql4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Recql4tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue
Recql4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Recql4tm3(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette)
Vector
Gene