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Gene: Prdm15 MGI:1930121

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Gene Summary

Name:
PR domain containing 15
Synonyms:
E130018M06Rik,  Zfp298

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Prdm15tm1b(EUCOMM)Wtsi HOM Early adult 0.00
increased heart left ventricle size Prdm15tm1b(EUCOMM)Wtsi HET Early adult 5.43×10-05
thick ventricular wall Prdm15tm1b(EUCOMM)Wtsi HET Early adult 4.35×10-06

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Bone N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 0.0% (0 of 2)
Brainstem N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cecum N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote Not available
Gall bladder N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 0.0% (0 of 2)
Hippocampus N/A heterozygote 0.0% (0 of 2)
Hypothalamus N/A heterozygote 0.0% (0 of 2)
Kidney N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote 0.0% (0 of 2)
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Oral epithelium N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 0.0% (0 of 2)
Testis N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vas deferens N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote 0.0% (0 of 2)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
mesenteric lymph node
olfactory lobe 0.0%
oral epithelium 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vas deferens Unavailable
vascular system 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

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MicroCT E18.5

Embryo reconstruction

3 Images

View images

Human diseases caused by Prdm15 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prdm15 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Microhydranencephaly, X-Linked
Intrauterine growth retardation, Holoprosencephaly OMIM:306990
Vissers-Bodmer Syndrome
Intrauterine growth retardation, Short stature, Holoprosencephaly OMIM:619033
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Holoprosencephaly 5
Syntelencephaly, Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosenceph... OMIM:609637
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydranencephaly, Hydrocephalus, Holoprosencephaly OMIM:617967
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Hartsfield Syndrome
Encephalocele, Intrauterine growth retardation, Lobar holoprosencephaly ORPHA:2117
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Hydranencephaly, Intrauterine growth retardation, Holoprosencephaly ORPHA:2570
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly OMIM:611638
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Short stature, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Holopro... ORPHA:1908
Distal Deletion 13Q
Encephalocele, Anencephaly, Holoprosencephaly, Short stature ORPHA:1590
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly, Anterior encephalocele OMIM:601357
Thanatophoric Dysplasia Type 2
Encephalocele, Hydrocephalus, Short stature, Holoprosencephaly ORPHA:93274
Holoprosencephaly 11
Holoprosencephaly OMIM:614226
Ring Chromosome 21 Syndrome
Short stature, Holoprosencephaly ORPHA:1445
Distal Monosomy 7Q36
Short stature, Holoprosencephaly ORPHA:1636
Lambotte Syndrome
Intrauterine growth retardation, Semilobar holoprosencephaly OMIM:245552
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Aqueductal stenosis, Hydrocephalus, Holoprosencephaly ORPHA:2182
Triploidy
Intrauterine growth retardation, Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:3376
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly OMIM:615433
Monosomy 18P
Short stature, Holoprosencephaly ORPHA:1598
1Q41Q42 Microdeletion Syndrome
Growth delay, Short stature, Holoprosencephaly ORPHA:250999
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Growth delay, Hydrocephalus, Holoprosencephaly ORPHA:77298
Microtia-Anotia
Holoprosencephaly OMIM:600674
Holoprosencephaly-Craniosynostosis Syndrome
Short stature, Holoprosencephaly ORPHA:2163
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly ORPHA:2165
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
Solitary Median Maxillary Central Incisor
Short stature, Holoprosencephaly OMIM:147250
Iniencephaly
Encephalocele, Rhizomelia, Spina bifida, Myelomeningocele, Hydrocephalus, Anencephaly, Spinal dys... ORPHA:63259
Microtia
Holoprosencephaly ORPHA:83463
Microform Holoprosencephaly
Intrauterine growth retardation, Short stature, Holoprosencephaly ORPHA:280200
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Encephalocele, Hydrocephalus, Holoprosencephaly OMIM:253800
Chromosome 1Q41-Q42 Deletion Syndrome
Short stature, Holoprosencephaly OMIM:612530
Pseudotrisomy 13 Syndrome
Encephalocele, Hydrocephalus, Holoprosencephaly OMIM:264480
Pancreatic Agenesis-Holoprosencephaly Syndrome
Intrauterine growth retardation, Holoprosencephaly, Semilobar holoprosencephaly ORPHA:556955
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly ORPHA:990
Halperin-Birk Syndrome
Umbilical hernia, Semilobar holoprosencephaly, Intrauterine growth retardation OMIM:618651
Short-Rib Thoracic Dysplasia 12
Hydrocephalus, Anencephaly, Holoprosencephaly, Neonatal death, Intrauterine growth retardation OMIM:269860
Trisomy 18
Short stature, Spina bifida, Anencephaly, Growth delay, Holoprosencephaly, Intrauterine growth re... ORPHA:3380
49,Xxxxy Syndrome
Short stature, Holoprosencephaly ORPHA:96264
Arachnoid Cyst
Encephalocele, Hydrocephalus, Holoprosencephaly ORPHA:2356
Meckel Syndrome 14
Occipital encephalocele, Holoprosencephaly OMIM:619879
Holoprosencephaly-Postaxial Polydactyly Syndrome
Encephalocele, Umbilical hernia, Hydrocephalus, Holoprosencephaly ORPHA:2166
16P13.11 Microdeletion Syndrome
Short stature, Holoprosencephaly ORPHA:261236
Holoprosencephaly 7
Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosencephaly, Occipital me... OMIM:610828
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Pallister-Hall Syndrome
Neonatal death, Intrauterine growth retardation, Short stature, Holoprosencephaly OMIM:146510
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
Short stature, Lobar holoprosencephaly OMIM:614701
Holoprosencephaly
Encephalocele, Hydrocephalus, Spinal dysraphism, Branchial anomaly, Holoprosencephaly ORPHA:2162
Jacobsen Syndrome
Intrauterine growth retardation, Hydrocephalus, Holoprosencephaly OMIM:147791
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Lobar holoprosencephaly, Growth delay, Neonatal death, Intrauterine growth retardation, Semilobar... OMIM:618500
Holoprosencephaly 14
Aqueductal stenosis, Hydrocephalus, Holoprosencephaly, Alobar holoprosencephaly OMIM:619895
Endocrine-Cerebroosteodysplasia
Hydrocephalus, Holoprosencephaly OMIM:612651
Mosaic Variegated Aneuploidy Syndrome
Growth delay, Intrauterine growth retardation, Short stature, Holoprosencephaly ORPHA:1052
Monosomy 13Q14
Intrauterine growth retardation, Short stature, Holoprosencephaly ORPHA:1587
Chromosome 13Q14 Deletion Syndrome
Growth delay, Umbilical hernia, Holoprosencephaly OMIM:613884
Holoprosencephaly 3
Holoprosencephaly OMIM:142945
Isolated Exencephaly
Holoprosencephaly ORPHA:563612
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Smith-Lemli-Opitz Syndrome
Rhizomelia, Short stature, Growth delay, Holoprosencephaly, Intrauterine growth retardation ORPHA:818
Hartsfield Syndrome
Growth delay, Semilobar holoprosencephaly, Lobar holoprosencephaly, Alobar holoprosencephaly OMIM:615465
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Intrauterine growth retardation, Severe short stature, Lobar holoprosencephaly ORPHA:468631
Holoprosencephaly 9
Hydrocephalus, Short stature, Holoprosencephaly OMIM:610829
Ring Chromosome 7 Syndrome
Holoprosencephaly, Short stature, Severe intrauterine growth retardation ORPHA:1449
Meckel Syndrome
Encephalocele, Hydrocephalus, Anencephaly, Lobar holoprosencephaly ORPHA:564
Smith-Lemli-Opitz Syndrome
Short stature, Hydrocephalus, Growth delay, Holoprosencephaly, Intrauterine growth retardation OMIM:270400
Charge Syndrome
Short stature, Aqueductal stenosis, Postnatal growth retardation, Holoprosencephaly, Delayed pube... ORPHA:138
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly ORPHA:3186
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly OMIM:618820
Orofaciodigital Syndrome Xiv
Occipital encephalocele, Holoprosencephaly OMIM:615948
Holoprosencephaly 13, X-Linked
Semilobar holoprosencephaly, Alobar holoprosencephaly OMIM:301043
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Growth delay, Intrauterine growth retardation, Semilobar holoprosencephaly OMIM:301044
Holoprosencephaly 2
Semilobar holoprosencephaly, Holoprosencephaly, Alobar holoprosencephaly OMIM:157170
Holoprosencephaly 1
Ethmocephaly, Short stature, Alobar holoprosencephaly OMIM:236100
Pallister-Hall Syndrome
Umbilical hernia, Short stature, Holoprosencephaly, Intrauterine growth retardation ORPHA:672
Combined Pituitary Hormone Deficiencies, Genetic Forms
Growth delay, Pituitary dwarfism, Holoprosencephaly, Delayed puberty ORPHA:95494
Townes-Brocks Syndrome 1
Umbilical hernia, Hydrocephalus, Holoprosencephaly OMIM:107480
Proboscis Lateralis
Holoprosencephaly ORPHA:141099
Charge Syndrome
Postnatal growth retardation, Umbilical hernia, Holoprosencephaly, Delayed puberty OMIM:214800
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly OMIM:129900
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prdm15

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prdm15.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis. Nature communications (July 2020) Prdm15tm1a(EUCOMM)Wtsi PMC7360777
PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly. Science Advances (January 2020) Prdm15tm1c(EUCOMM)Wtsi Prdm15tm1a(EUCOMM)Wtsi PMC6954057
PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling. Nature genetics (July 2017) Prdm15tm1a(EUCOMM)Wtsi 28740264

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MGI Allele Allele Type Produced
Prdm15tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Prdm15tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Prdm15tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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