Gene: Nampt

Order

Name nicotinamide phosphoribosyltransferase

Synonyms
  • 1110035O14Rik
  • Visfatin
  • Pbef1

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1929865    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Nampt

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nampt data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal brain morphology Nampttm1.1(KOMP)Vlcg HET Male postnatal 0.0
abnormal embryo size Nampttm1.1(KOMP)Vlcg HET Female embryonic day 9.5 0.0
abnormal heart morphology Nampttm1.1(KOMP)Vlcg HET Male postnatal 0.0
abnormal neural tube morphology Nampttm1.1(KOMP)Vlcg HET Female embryonic day 9.5 0.0
abnormal skin morphology Nampttm1.1(KOMP)Vlcg HET Male postnatal 0.0
embryonic lethality prior to tooth bud stage Nampttm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
enlarged heart Nampttm1.1(KOMP)Vlcg HET Male postnatal 0.0
hydrocephaly Nampttm1.1(KOMP)Vlcg HET Male postnatal 0.0
pale yolk sac Nampttm1.1(KOMP)Vlcg HET Female embryonic day 9.5 0.0
preweaning lethality, complete penetrance Nampttm1.1(KOMP)Vlcg HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (1/2)
Aorta 2 No (2/2)
Blood 2 No
Bone marrow 2 No (1/2)
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No
Cecum 2 No (12/383) (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No
Chest bone 2 No
Colon 2 No (12/127) (2/2)
Diaphragm 2 No (2/2)
Duodenum 2 No (2/127) (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Gall bladder 2 No
Gonadal fat pad 2 No
Harderian gland 2 No (1/2)
Heart 2 No
Hindlimb 2 No
Hippocampus 2 No
Hypothalamus 2 No
Ileum 2 No (14/127) (2/2)
Jejunum 2 No (6/127)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No (1/2)
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No
Mesenteric adipose tissue 2 No (2/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Parotid gland 2 No
Penis 2 No (1/2)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584) (1/2)
Quadriceps 2 No (2/2)
Sciatic nerve 2 No
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (1/2)
Stomach 2 No (12/584) (2/2)
Stomach pyloric region 2 No
Striatum 2 No
Sublingual gland 2 No (1/2)
Submandibular gland 2 No (2/132)
Testis 2 No (2/584) (1/2)
Thymus 2 No (1/2)
Thyroid gland 2 No (15/584) (1/2)
Tongue 2 No (5/127) (2/2)
Trachea 2 No (2/2)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No
Vagina 2 No
Vas deferens 2 No (15/388) (1/2)
Vascular system 2 No
Vesicular gland 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system endocrine system digestive system cardiovascular system set of connective tissues reproductive system adipose tissue musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 6 (1/47)
Axial skeleton 6 (1/51)
Brain 6 (6/485)
Central nervous system ganglion 6 (1/51)
Dorsal root ganglion 6 (1/47)
Ear 6 (1/485)
Embryo 6 (1/485) (6/6)
Outer ear 6 (1/47)
Eye 6 (1/485)
Foot 6 (1/485) (3/6)
Forearm 6 (1/282)
Forebrain 6 (1/485)
Forelimb 6 (1/485)
Fronto-nasal process 6 (1/48)
Gut 6 (1/50)
Hand 6 (1/485) (1/6)
Head 6 (5/485)
Head mesenchyme 5 (1/47)
Heart 6 (1/485)
Heart ventricle 6 (1/47)
Hindbrain 6 (6/485)
Hindlimb 6 (1/485)
Intestine 6 (1/47)
Liver 6 (1/485)
Lower leg 6 (1/282)
Lung 6 (1/485) (2/6)
Mandibular process 6 (1/485)
Maxillary process 6 (1/485)
Meckel's cartilage 6
Midbrain 6 (1/485)
Nasal septum 6 (1/47)
Nose 6 (1/51)
Notochord 6 (1/47)
Oral cavity 6 (1/485)
Outflow tract 6 (1/47)
Pericardium 6 (1/46)
6 (7/25)
Skeleton 6 (1/51)
Skin 6 (1/485)
Spinal cord 6 (1/50) (6/6)
Tail 6 (1/485)
Tail somite 6 (1/485)
Thoracic vertebral cartilage condensation 6 (1/46)
Trunk mesenchyme 6 (1/47)
Upper arm 6 (1/282)
Upper leg 6 (1/282)
Vibrissa 6 (1/47)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    20 Images
  • X-ray: XRay Images Dorso Ventral
    40 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nampttm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Nampttm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue
Nampttm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene