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Gene: Sec1 MGI:1928893

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Gene Summary

Name:
secretory blood group 1
Synonyms:
Fut3,  GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased heart weight Sec1tm1a(EUCOMM)Wtsi HOM Early adult 3.42×10-06

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

16 Images

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X-ray

XRay Images Skull Lateral Orientation

13 Images

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X-ray

XRay Images Whole Body Dorso Ventral

15 Images

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Legacy Phenotype Associated Images
Sec1tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Sec1tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Sec1tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Sec1tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Sec1tm1a(EUCOMM)Wtsi
HOM, Male, WTSI

View all 72 images

Sec1tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Sec1tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Sec1tm1a(EUCOMM)Wtsi
mydriasis, abnormal pupil morphology, HOM, Female, WTSI

Human diseases caused by Sec1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Sec1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ethanolaminosis
Cardiomegaly OMIM:227150
Immunodeficiency 30
Recurrent mycobacterial infections, Recurrent infections OMIM:614891
Immunodeficiency 28
Recurrent mycobacterial infections OMIM:614889
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Cardiomyopathy, Dilated, 1I
Dilated cardiomyopathy, Cardiomegaly OMIM:604765
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Cardiomegaly ORPHA:88643
Cardiomyopathy, Familial Hypertrophic, 27
Cardiomegaly, Concentric hypertrophic cardiomyopathy, Ventricular septal hypertrophy, Cardiomyocy... OMIM:618052
Congenital Tricuspid Valve Dysplasia
Hepatomegaly, Cardiomegaly, Pericardial effusion, Anomalous pulmonary venous return, Abnormal tri... ORPHA:555874

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sec1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sec1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Intestinal SEC16B modulates obesity by regulating chylomicron metabolism. Molecular metabolism (February 2023) Sec16btm1c(KOMP)Wtsi Sec16btm1a(KOMP)Wtsi PMC9976576
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Sec1tm1a(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Sec1tm1a(EUCOMM)Wtsi Sec16btm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Sec1tm1a(EUCOMM)Wtsi Sec16btm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Sec1tm1a(EUCOMM)Wtsi PMC5827107

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sec1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Sec1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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