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Gene: Gpr37l1 MGI:1928503

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
G protein-coupled receptor 37-like 1
Synonyms:
D0Kist8,  CAG-18

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gpr37l1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr37l1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Platelet Prostacyclin Receptor Defect
Intermittent claudication OMIM:262875
Raynaud Disease
Raynaud phenomenon OMIM:179600
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect, Type II lissencephaly, Cerebellar dysplasia OMIM:615041
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Cardiogenic Shock
Abnormal EKG, Increased pulmonary capillary wedge pressure, Cardiac arrest, Myocardial infarction... ORPHA:97292
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Spinocerebellar Ataxia Type 27
Cerebellar atrophy, Akinesia, Limb ataxia, Gait ataxia, Gait disturbance, Difficulty walking, Tru... ORPHA:98764
Congenital Aortic Valve Stenosis
Angina pectoris, Sudden cardiac death, Increased QRS voltage, Heart murmur, Abnormal left ventric... ORPHA:3093
Antithrombin Iii Deficiency
Arterial occlusion, Pulmonary embolism OMIM:613118
Spinocerebellar Ataxia Type 21
Akinesia, Gait ataxia, Progressive cerebellar ataxia, Cognitive impairment, Cerebellar vermis atr... ORPHA:98773
Chudley-Mccullough Syndrome
Hydrocephalus, Gray matter heterotopia, Cerebellar hypoplasia, Polymicrogyria, Cerebellar dysplasia OMIM:604213
Spinocerebellar Ataxia 21
Cerebellar atrophy, Ataxia, Akinesia, Limb ataxia, Gait ataxia, Progressive cerebellar ataxia, Co... OMIM:607454
Pheochromocytoma/Paraganglioma Syndrome 6
Hypertension OMIM:618464
Neurodegeneration With Brain Iron Accumulation 5
Cerebellar atrophy, Dementia, Mental deterioration, Akinesia OMIM:300894
Congenital Analbuminemia
Low pulse pressure ORPHA:86816
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia, Hydrocephalus, Cerebellar hypoplasia, Hydranencephaly, Pterygium, Polymicrogyria, Dandy... OMIM:225790
Hyperaldosteronism, Familial, Type Iv
Hypertension OMIM:617027
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Ataxia, Akinesia, Gait ataxia, Dysdiadochokinesis, Dementia, Shuffling gait, Memory impairment, C... ORPHA:247234
Fibromuscular Dysplasia, Arterial
Renovascular hypertension, Myocardial infarction, Intermittent claudication OMIM:135580
Exercise-Induced Malignant Hyperthermia
Prolonged QT interval, ST segment depression, Hypotension, Abnormal T-wave, Abnormal pulse pressu... ORPHA:466650
Atrial Fibrillation, Familial, 14
ST segment elevation, Paroxysmal atrial fibrillation, Hypertension, Prolonged PR interval OMIM:615378
Ataxia-Intellectual Disability-Oculomotor Apraxia-Cerebellar Cysts Syndrome
Dilated fourth ventricle, Cerebellar dysplasia, Ataxia, Elongated superior cerebellar peduncle, C... ORPHA:370022
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Freezing of gait, Akinesia, Unsteady gait, Blepharospasm, Dementia, Falls, Gait imbalance, Loss o... ORPHA:240094
Mitochondrial Complex I Deficiency, Nuclear Type 28
Cerebellar atrophy, Choreoathetosis, Akinesia, Truncal ataxia OMIM:618249
Aceruloplasminemia
Ataxia, Akinesia, Chorea, Limb ataxia, Gait ataxia, Blepharospasm, Cognitive impairment, Abnormal... ORPHA:48818
Hyperaldosteronism, Familial, Type Ii
Hypertension OMIM:605635
Corticobasal Syndrome
Somatic sensory dysfunction, Akinesia, Dementia, Gait disturbance, Memory impairment ORPHA:454887
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Hypertension OMIM:605115
Classic Progressive Supranuclear Palsy Syndrome
Akinesia, Social and occupational deterioration, Blepharospasm, Falls, Gait imbalance, Mental det... ORPHA:240071
Atypical Juvenile Parkinsonism
Akinesia, Inability to walk, Gait ataxia, Shuffling gait, Short stepped shuffling gait ORPHA:391411
Fetal Akinesia Deformation Sequence
Akinesia, Pterygium, Dandy-Walker malformation ORPHA:994
Kufor-Rakeb Syndrome
Ataxia, Akinesia, Distal sensory impairment, Dementia, Gait disturbance OMIM:606693
Manganese Poisoning
Memory impairment, Gait disturbance, Confusion, Akinesia ORPHA:306682
Perry Syndrome
Frontotemporal dementia, Short stepped shuffling gait, Akinesia OMIM:168605
Parkinson Disease 23, Autosomal Recessive Early-Onset
Mental deterioration, Dementia, Akinesia OMIM:616840
Multiple Pterygium Syndrome, Lethal Type
Epicanthus, Akinesia, Multiple pterygia OMIM:253290
Parkinson Disease 17
Akinesia OMIM:614203
Postencephalitic Parkinsonism
Bilateral ptosis, Paresthesia, Akinesia ORPHA:97349
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Freezing of gait, Akinesia OMIM:619911
Congenital Myopathy 9A
Akinesia OMIM:618822
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Supranuclear Palsy, Progressive, 2
Eyelid apraxia, Akinesia, Falls, Gait imbalance, Memory impairment, Frontolimbic dementia OMIM:609454
Neurodegeneration With Brain Iron Accumulation 1
Eyelid apraxia, Ataxia, Akinesia, Choreoathetosis, Blepharospasm, Dementia, Gait disturbance, Men... OMIM:234200
Hereditary Late-Onset Parkinson Disease
Mental deterioration, Dementia, Shuffling gait, Akinesia ORPHA:411602
Dpagt1-Cdg
Ataxia, Akinesia, Inability to walk, Abnormal cerebellum morphology, Cerebellar hypoplasia ORPHA:86309
Congenital Myopathy 12
Akinesia OMIM:612540
Supranuclear Palsy, Progressive, 1
Eyelid apraxia, Akinesia, Falls, Gait imbalance, Memory impairment, Frontolimbic dementia OMIM:601104
Gaucher Disease, Perinatal Lethal
Akinesia, Progressive neurologic deterioration OMIM:608013
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Arthrogryposis Multiplex Congenita 5
Upslanted palpebral fissure, Akinesia, Ptosis OMIM:618947
African Trypanosomiasis
Somatic sensory dysfunction, Akinesia, Myelopathy, Impaired proprioception, Choreoathetosis, Gait... ORPHA:3385

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr37l1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr37l1.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. Cells (June 2022) Gpr37l1tm1d(EUCOMM)Wtsi PMC9180194
Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International journal of molecular sciences (April 2022) Gpr37l1tm1a(EUCOMM)Wtsi Gpr37l1tm1b(EUCOMM)Wtsi Gpr37l1tm1d(EUCOMM)Wtsi PMC9025225
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner. Frontiers in pharmacology (January 2020) Gpr37l1tm1a(EUCOMM)Wtsi PMC7901490
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences (April 2018) Gpr37l1tm1c(EUCOMM)Wtsi Gpr37l1tm1a(EUCOMM)Wtsi PMC5889568

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MGI Allele Allele Type Produced
Gpr37l1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Gpr37l1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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