Gene: Sirt3

Order

Name sirtuin 3

Synonyms
  • Sir2l3
  • 2310003L23Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1927665    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Sirt3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Sirt3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal gait Sirt3tm1b(EUCOMM)Wtsi HOM Male postnatal 1.58E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 6 No (2/415) (4/6)
Aorta 6 No (3/6)
Bone 6 No
Brain 6 No (4/6)
Brainstem 6 No (4/6)
Brown adipose tissue 6 No (4/6)
Cartilage tissue 6 No (4/6)
Cerebellum 6 No (4/6)
Cerebral cortex 6 No (4/6)
Esophagus 6 No (7/415)
Eye 6 No
Gall bladder 6 No (4/6)
Heart 6 No (4/6)
Hippocampus 6 No (4/6)
Hypothalamus 6 No (4/6)
Kidney 6 No (18/584) (4/6)
Large intestine 6 No (10/584) (1/6)
Liver 6 No (4/6)
Lower urinary tract 6 No (3/6)
Lung 6 No (3/6)
Lymph node 6 No
Mammary gland 6 No
Olfactory lobe 6 No (4/6)
Oral epithelium 6 No
Ovary 6 No (1/584)
Oviduct 6 No (3/6)
Pancreas 6 No (5/584)
Parathyroid gland 6 No (4/6)
Peripheral nervous system 6 No (3/6)
Peyer's patch 6 No
Pituitary gland 6 No (4/6)
Prostate gland 6 No (12/584)
Skeletal muscle 6 No
Skin 6 No
Small intestine 6 No (9/584)
Spinal cord 6 No (4/6)
Spleen 6 No (2/584)
Stomach 6 No (12/584) (4/6)
Striatum 6 No (4/6)
Testis 6 No (2/584) (2/6)
Thymus 6 No
Thyroid gland 6 No (15/584) (4/6)
Trachea 6 No (4/6)
Uterus 6 No (3/6)
Vascular system 6 No
White adipose tissue 6 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    cardiovascular system
    nervous system
    set of connective tissues
    reproductive system
    adipose tissue
    trunk
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Wholemount
    17 Images
  • Echo: M-Mode Images
    36 Images
  • X-ray: XRay Images Dorso Ventral
    53 Images
  • X-ray: XRay Images Lateral Orientation
    44 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    30 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Forepaw
    9 Images
Legacy Phenotype Associated Images
Xray (105)
  • Sirt3tm1a(EUCOMM)Wtsi
    forearm, WT, Female, WTSI
  • Sirt3tm1a(EUCOMM)Wtsi
    body, WT, Female, WTSI
  • Sirt3tm1a(EUCOMM)Wtsi
    head, WT, Female, WTSI
  • Sirt3tm1a(EUCOMM)Wtsi
    forearm, WT, Female, WTSI
  • Sirt3tm1a(EUCOMM)Wtsi
    forearm, WT, Female, WTSI

show all 105 images

Skin Histopathology (1)
  • Sirt3tm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Sirt3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Sirt3tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Sirt3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Sirt3tm47264(L1L2_gt1)
Vector
Gene