Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Wtap by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Wtap.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis. | The Journal of biological chemistry (November 2022) | Wtaptm1c(EUCOMM)Hmgu | PMC9791132 |
The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. | Nature immunology (July 2022) | Wtaptm1c(EUCOMM)Hmgu | 35879451 |
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation. | Nature communications (September 2021) | Wtaptm1c(EUCOMM)Hmgu | PMC8410761 |
WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche. | Stem cell reports (October 2020) | Wtaptm1a(EUCOMM)Hmgu | PMC7566211 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Wtaptm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Wtaptm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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