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Genes Phenotypes Help, News, Blog

Gene: Nln MGI:1923055

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
neurolysin (metallopeptidase M3 family)
Synonyms:
4930472G13Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nln mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nln by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Type 1 Diabetes Mellitus 15
Type I diabetes mellitus, Diabetes mellitus OMIM:601666
Type 2 Diabetes Mellitus
Increased waist to hip ratio, Insulin resistance, Type II diabetes mellitus OMIM:125853
Hyperinsulinism Due To Insr Deficiency
Fatigue, Hypoglycemia, Insulin resistance, Fasting hyperinsulinemia, Recurrent hypoglycemia, Hype... ORPHA:263458
Congenital Glucokinase-Related Hyperinsulinism
Fatigue, Fasting hyperinsulinemia, Recurrent hypoglycemia, Type II diabetes mellitus, Hyperinsuli... ORPHA:79299
Coronary Artery Disease, Autosomal Dominant 2
Glucose intolerance, Impaired glucose tolerance, Type II diabetes mellitus, Sudden cardiac death OMIM:610947
Hypogonadism, Male, With Mental Retardation And Skeletal Anomalies
Glucose intolerance, Hyperglycemia OMIM:307500
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Fatigue, Reactive hypoglycemia, Hyperinsulinemia, Increased body weight, Fasting hypoglycemia, Hy... ORPHA:276608
X-Linked Sideroblastic Anemia
Fatigue, Glucose intolerance ORPHA:75563
Hemochromatosis, Type 4
Fatigue, Diabetes mellitus, Impaired glucose tolerance, Glucose intolerance, Arthralgia OMIM:606069
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Fatigue, Diabetes mellitus, Small for gestational age, Increased body weight, Type II diabetes me... OMIM:274300
Mody
Large for gestational age, Overweight, Transient neonatal diabetes mellitus, Insulin-resistant di... ORPHA:552
Acth-Independent Macronodular Adrenal Hyperplasia 2
Fatigue, Hyperglycemia, Increased body weight, Abdominal obesity OMIM:615954
Insulin-Resistance Syndrome Type B
Fatigue, Abnormality of body weight, Insulin resistance, Fasting hyperinsulinemia, Insulin-resist... ORPHA:2298

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nln

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nln.

No publications found that use IMPC mice or data for Nln.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nlntm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nlntm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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