Gene: Herc3

Order

Name hect domain and RLD 3

Synonyms 5730409F18Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1921248    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Herc3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Herc3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
trunk curl Herc3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.54E-10
tremors Herc3tm1a(EUCOMM)Wtsi HOM Female postnatal 6.78E-7
increased prepulse inhibition Herc3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.13E-5
decreased body weight Herc3tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.39E-5
abnormal tail movements Herc3tm1a(EUCOMM)Wtsi HOM Male postnatal 4.61E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No
Aorta 3 No
Blood vessel 3 No
Bone 3 No
Brain 3 No (2/3)
Brainstem 3 No
Brown adipose tissue 3 No
Cartilage tissue 3 No
Cerebellum 3 No
Cerebral cortex 3 No
Eye 3 No (1/3)
Gall bladder 3 No
Heart 3 No (2/3)
Hippocampus 3 No
Hypothalamus 3 No
Kidney 3 No (18/584) (2/3)
Large intestine 3 No (10/584)
Liver 3 No
Lower urinary tract 3 No (1/3)
Lung 3 No
Lymph node 3 No
Mammary gland 3 No
Esophagus 3 No
Olfactory lobe 3 No
Ovary 3 No (1/584) (2/3)
Oviduct 3 No (2/3)
Pancreas 3 No (5/584)
Parathyroid gland 3 No
Peripheral nervous system 3 No (2/3)
Peyer's patch 3 No
Pituitary gland 3 No
Prostate gland 3 No (12/584)
Skeletal muscle tissue 3 No (2/3)
Skin 3 No
Small intestine 3 No (9/584)
Spinal cord 3 No (2/3)
Spleen 3 No (2/584)
Stomach 3 No (12/584)
Striatum 3 No
Testis 3 No (2/584)
Thymus 3 No
Thyroid gland 3 No (15/584)
Trachea 3 No
Uterus 3 No
White adipose tissue 3 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse cardiovascular system nervous system sensory organ reproductive system musculoskeletal system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (9)
  • Herc3tm1a(EUCOMM)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    oviduct, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI

show all 9 images

trunk (4)
  • Herc3tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    oviduct, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
nervous system (3)
  • Herc3tm1a(EUCOMM)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
urinary system (2)
  • Herc3tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    lower urinary tract, HET, Male, WTSI
cardiovascular system (1)
  • Herc3tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
musculoskeletal system (1)
  • Herc3tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
reproductive system (1)
  • Herc3tm1a(EUCOMM)Wtsi
    oviduct, HET, Female, WTSI
sensory organ (1)
  • Herc3tm1a(EUCOMM)Wtsi
    eye, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (189)
  • Herc3tm1a(EUCOMM)Wtsi
    forelimb, WT, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    WT, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    body, HOM, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    WT, Female, WTSI

show all 189 images

Tail Epidermis Wholemount (5)
  • Herc3tm1a(EUCOMM)Wtsi
    tail skin, WT, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    abnormal hair follicle bulge morphology, HOM, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    tail skin, WT, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    abnormal hair follicle bulge morphology, HOM, Female, WTSI
  • Herc3tm1a(EUCOMM)Wtsi
    abnormal hair follicle bulge morphology, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Herc3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene