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Gene: Hepacam MGI:1920177

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
hepatocyte cell adhesion molecule
Synonyms:
2900042E01Rik,  Glialcam

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Hepacam mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Hepacam by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2B, Remitting, With Or Without Impaired Intellectual Development
Diffuse swelling of cerebral white matter, Diffuse white matter abnormalities, Megalencephaly OMIM:613926
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2A
Diffuse swelling of cerebral white matter, Diffuse white matter abnormalities, Cerebral atrophy, ... OMIM:613925
Macrocephaly-Intellectual Disability-Autism Syndrome
ORPHA:210548

The table below shows human diseases predicted to be associated to Hepacam by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 3
Gliosis, Cerebral edema OMIM:608033
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 4
Cerebral edema OMIM:614212
Glioblastoma
Abnormal cerebral white matter morphology, Cerebral edema, Abnormal corpus callosum morphology ORPHA:360
Kcnq2-Related Epileptic Encephalopathy
Abnormal globus pallidus morphology, Cerebral atrophy, Abnormal cerebral white matter morphology,... ORPHA:439218
Focal Cortical Dysplasia, Type Ii
Cortical dysplasia, Focal cortical dysplasia type II, Hemimegalencephaly, Astrocytosis, Focal whi... OMIM:607341
Familial Acute Necrotizing Encephalopathy
Abnormal putamen morphology, Gliosis, Cerebral edema ORPHA:88619
Neurodevelopmental Disorder With Microcephaly, Hypotonia, Nystagmus, And Seizures
Corpus callosum atrophy, Cerebral edema, Cerebral atrophy, Microcephaly OMIM:619876
Hyperglycinemia, Lactic Acidosis, And Seizures
Cerebral edema, Cerebral atrophy, Microcephaly OMIM:614462
Carbamoyl Phosphate Synthetase I Deficiency, Hyperammonemia Due To
Cerebral edema OMIM:237300
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of
Cerebral edema OMIM:201450
Alzheimer Disease, Familial Early-Onset, With Coexisting Amyloid And Prion Pathology
Neurofibrillary tangles, Cerebral cortex with spongiform changes OMIM:605055
Maple Syrup Urine Disease
Cerebral edema OMIM:248600
Early-onset Alzheimer disease with cerebral amyloid angiopathy
Neurofibrillary tangles DECIPHER:48
Alzheimer Disease 2
Neurofibrillary tangles OMIM:104310
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Abnormal cerebral white matter morphology, Gliosis, Cerebral edema, Cerebral atrophy OMIM:618321
Reversible Cerebral Vasoconstriction Syndrome
Ischemic stroke, Cerebral edema, Leukoencephalopathy ORPHA:284388
Citrullinemia, Type Ii, Adult-Onset
Cerebral edema OMIM:603471
Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis
Abnormal cerebral white matter morphology, Cerebral edema ORPHA:83601
Spongiform Encephalopathy With Neuropsychiatric Features
Neurofibrillary tangles, Cerebral cortex with spongiform changes, Gliosis OMIM:606688
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 1
Cerebral white matter atrophy, Cerebral edema, Leukoencephalopathy OMIM:617186
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8
Neurofibrillary tangles, Amyotrophic lateral sclerosis OMIM:619132
Mitochondrial Complex I Deficiency, Nuclear Type 20
Cerebral edema OMIM:611126
Migraine, Familial Hemiplegic, 2
Cerebral edema OMIM:602481
Acute Disseminated Encephalomyelitis
Hypointensity of cerebral white matter on MRI, Diffuse white matter abnormalities, Abnormal basal... ORPHA:83597
Herpes Simplex Virus Encephalitis
Cerebral edema ORPHA:1930
Combined Oxidative Phosphorylation Deficiency 33
Cerebral edema, Oligohydramnios OMIM:617713
Alzheimer Disease, Familial, 1
Neurofibrillary tangles OMIM:104300
Acyl-Coa Dehydrogenase 9 Deficiency
Cerebral edema ORPHA:99901
Dural Sinus Malformation
Hypoplasia of the frontal lobes, Cerebral edema ORPHA:97339
Japanese Encephalitis
Abnormal substantia nigra morphology, Abnormal caudate nucleus morphology, Abnormal cerebral morp... ORPHA:79139
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Pachygyria, Lissencephaly, Cerebral edema, Astrocytosis ORPHA:258
Mitochondrial Complex Iv Deficiency, Nuclear Type 22
Cerebral edema OMIM:619355
Angiostrongyliasis
Cerebral edema ORPHA:74
Familial Or Sporadic Hemiplegic Migraine
Cerebral edema ORPHA:569
Lujo Hemorrhagic Fever
Facial edema, Periorbital edema, Cerebral edema, Generalized edema ORPHA:319213
Alzheimer Disease 9, Susceptibility To
Neurofibrillary tangles, Hippocampal atrophy, Cerebral cortical atrophy OMIM:608907
Citrullinemia Type Ii
Cerebral edema ORPHA:247585
Citrullinemia, Classic
Cerebral edema OMIM:215700
Amoebiasis Due To Free-Living Amoebae
Abnormal basal ganglia morphology, Abnormal cerebral white matter morphology, Encephalomalacia, A... ORPHA:68
Ethylene Glycol Poisoning
Cerebral edema, Pulmonary edema ORPHA:31826
Mitochondrial Complex I Deficiency, Nuclear Type 1
Microcephaly, Focal T2 hypointense basal ganglia lesion, Leukoencephalopathy, Focal T2 hyperinten... OMIM:252010
Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To
Cerebral edema OMIM:311250
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2B, Remitting, With Or Without Impaired Intellectual Development
Diffuse swelling of cerebral white matter, Diffuse white matter abnormalities, Megalencephaly OMIM:613926
Cryptococcosis
Pleural effusion, Cerebral cortical atrophy, Cerebral edema ORPHA:1546
Progressive Non-Fluent Aphasia
Neurofibrillary tangles, Temporal cortical atrophy, Astrocytosis, Frontotemporal cerebral atrophy... ORPHA:100070
Argininosuccinic Aciduria
Cerebral edema OMIM:207900
X-Linked Intellectual Disability, Snyder Type
Cerebral edema, Megalencephaly ORPHA:3063
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Neurofibrillary tangles, Lewy bodies, Gliosis, Cerebral cortical atrophy OMIM:607485
Parkinson Disease 23, Autosomal Recessive Early-Onset
Neurofibrillary tangles, Lewy bodies, Cerebral cortical atrophy OMIM:616840
Acute Liver Failure
Cerebral edema ORPHA:90062
Alzheimer Disease 3
Neurofibrillary tangles, Cerebral cortical atrophy OMIM:607822
Supranuclear Palsy, Progressive, 1
Neuronal loss in basal ganglia, Neurofibrillary tangles, Cerebral atrophy, Granulovacuolar degene... OMIM:601104
Alzheimer Disease 4
Neurofibrillary tangles OMIM:606889
Early-Onset Autosomal Dominant Alzheimer Disease
Neurofibrillary tangles, Cerebral cortical atrophy ORPHA:1020
Supranuclear Palsy, Progressive, 2
Neurofibrillary tangles, Neuronal loss in basal ganglia, Gliosis, Granulovacuolar degeneration OMIM:609454
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Neurofibrillary tangles OMIM:117300
Niemann-Pick Disease, Type C1
Neurofibrillary tangles, Fetal ascites OMIM:257220
Niemann-Pick Disease, Type C2
Neurofibrillary tangles, Fetal ascites, Polyhydramnios OMIM:607625
Neurodegeneration With Brain Iron Accumulation 2B
Neurofibrillary tangles, Lewy bodies, Cerebral atrophy OMIM:610217
Gerstmann-Straussler Disease
Neurofibrillary tangles OMIM:137440
Adult-Onset Dystonia-Parkinsonism
Neurofibrillary tangles, Frontotemporal cerebral atrophy, Generalized cerebral atrophy/hypoplasia ORPHA:199351
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2A
Diffuse swelling of cerebral white matter, Diffuse white matter abnormalities, Cerebral atrophy, ... OMIM:613925
Macrocephaly-Intellectual Disability-Autism Syndrome
ORPHA:210548

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hepacam

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hepacam.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Hepacamem1(IMPC)Wtsi PMC7263671

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MGI Allele Allele Type Produced
Hepacamem1(IMPC)Wtsi Deletion Mice
Hepacamtm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Hepacamtm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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