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Gene: Trim29 MGI:1919419

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Gene Summary

Name:
tripartite motif-containing 29
Synonyms:
2810431N19Rik,  1110047J21Rik,  4732461M22Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Trim29tm1b(EUCOMM)Wtsi HOM Early adult 4.24×10-06
increased grip strength Trim29tm1a(EUCOMM)Wtsi HOM Early adult 5.22×10-05
increased lean body mass Trim29tm1b(EUCOMM)Wtsi HOM Early adult 8.66×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 0.0% (0 of 4)
Aorta N/A heterozygote 0.0% (0 of 4)
Blood vessel N/A heterozygote 0.0% (0 of 4)
Bone N/A heterozygote 0.0% (0 of 4)
Brain N/A heterozygote 0.0% (0 of 4)
Brainstem N/A heterozygote 0.0% (0 of 4)
Brown adipose tissue N/A heterozygote 0.0% (0 of 4)
Cartilage tissue N/A heterozygote 0.0% (0 of 4)
Cerebellum N/A heterozygote 0.0% (0 of 4)
Cerebral cortex N/A heterozygote 0.0% (0 of 4)
Eye N/A heterozygote 100% (4 of 4)
Gall bladder N/A heterozygote 0.0% (0 of 4)
Heart N/A heterozygote 0.0% (0 of 4)
Hippocampus N/A heterozygote 0.0% (0 of 4)
Hypothalamus N/A heterozygote 0.0% (0 of 4)
Kidney N/A heterozygote 75% (3 of 4)
Large intestine N/A heterozygote 0.0% (0 of 4)
Liver N/A heterozygote 0.0% (0 of 4)
Lower urinary tract N/A heterozygote 75% (3 of 4)
Lung N/A heterozygote 0.0% (0 of 4)
Lymph node N/A heterozygote 0.0% (0 of 4)
Mammary gland N/A heterozygote 50% (2 of 4)
Esophagus N/A heterozygote 100% (4 of 4)
Olfactory lobe N/A heterozygote 0.0% (0 of 4)
Ovary N/A heterozygote 25% (1 of 4)
Oviduct N/A heterozygote 0.0% (0 of 4)
Pancreas N/A heterozygote 0.0% (0 of 4)
Parathyroid gland N/A heterozygote 0.0% (0 of 4)
Peripheral nervous system N/A heterozygote 0.0% (0 of 4)
Peyer's patch N/A heterozygote 0.0% (0 of 4)
Pituitary gland N/A heterozygote 0.0% (0 of 4)
Prostate gland N/A heterozygote 0.0% (0 of 4)
Skeletal muscle tissue N/A heterozygote 0.0% (0 of 4)
Skin N/A heterozygote 100% (4 of 4)
Small intestine N/A heterozygote 0.0% (0 of 4)
Spinal cord N/A heterozygote 0.0% (0 of 4)
Spleen N/A heterozygote 0.0% (0 of 4)
Stomach N/A heterozygote 100% (4 of 4)
Striatum N/A heterozygote 0.0% (0 of 4)
Testis N/A heterozygote 50% (2 of 4)
Thymus N/A heterozygote 50% (2 of 4)
Thyroid gland N/A heterozygote 0.0% (0 of 4)
Trachea N/A heterozygote 0.0% (0 of 4)
Uterus N/A heterozygote 0.0% (0 of 4)
White adipose tissue N/A heterozygote 0.0% (0 of 4)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood vessel
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
oesophagus
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyer's patch
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle tissue
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
uterus 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

26 Images

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X-ray

XRay Images Whole Body Lateral Orientation

28 Images

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X-ray

XRay Images Skull Lateral Orientation

28 Images

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X-ray

XRay Images Whole Body Dorso Ventral

28 Images

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DSS Histology

Images

6 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

24 Images

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Legacy Phenotype Associated Images
Trim29tm1a(EUCOMM)Wtsi
HOM, Female, WTSI
Trim29tm1a(EUCOMM)Wtsi
HOM, Female, WTSI
Trim29tm1a(EUCOMM)Wtsi
HOM, Female, WTSI
Trim29tm1a(EUCOMM)Wtsi
HOM, Female, WTSI
Trim29tm1a(EUCOMM)Wtsi
HOM, Female, WTSI

View all 134 images

Trim29tm1a(EUCOMM)Wtsi
TS20 oral cavity, HET, Unsexed, WTSI
Trim29tm1b(EUCOMM)Wtsi
TS20 head, HET, Female, WTSI
Trim29tm1b(EUCOMM)Wtsi
TS20 eye, HET, Female, WTSI
Trim29tm1a(EUCOMM)Wtsi
TS20 skin, HOM, Unsexed, WTSI
Trim29tm1a(EUCOMM)Wtsi
TS20 oral cavity, HOM, Unsexed, WTSI

View all 7 images

Trim29tm1a(EUCOMM)Wtsi
right eye, eyelids fail to open, HOM, Female, WTSI
Trim29tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI

Human diseases caused by Trim29 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trim29

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trim29.

There are 10 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Trim29tm1a(EUCOMM)Wtsi Trim29tm1b(EUCOMM)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Trim29tm1a(EUCOMM)Wtsi Trim29tm1b(EUCOMM)Wtsi PMC6671969
Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions. Journal of immunology (Baltimore, Md. : 1950) (July 2019) Trim29tm1c(EUCOMM)Wtsi Trim29tm1a(EUCOMM)Wtsi PMC6684831
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis. Genes & development (May 2019) Trim29tm1a(EUCOMM)Wtsi PMC6546061
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Trim29tm1a(EUCOMM)Wtsi Trim29tm1b(EUCOMM)Wtsi PMC6459510
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus. Journal of immunology (Baltimore, Md. : 1950) (May 2018) Trim29tm1a(EUCOMM)Wtsi PMC6092021
TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nature communications (October 2017) Trim29tm1a(EUCOMM)Wtsi PMC5643338
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Trim29tm1b(EUCOMM)Wtsi Trim29tm1a(EUCOMM)Wtsi PMC5827107
Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. Nature immunology (October 2016) Trim29tm1a(EUCOMM)Wtsi Trim29tm1b(EUCOMM)Wtsi PMC5558830
A gene expression resource generated by genome-wide lacZ profiling in the mouse. Disease models & mechanisms (August 2015) Trim29tm1b(EUCOMM)Wtsi PMC4631787

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Trim29tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Trim29tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Trim29tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Trim29tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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