Gene: Pnpt1

Order

Name polyribonucleotide nucleotidyltransferase 1

Synonyms
  • polynucleotide phosphorylase
  • PNPase
  • 1200003F12Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1918951    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Pnpt1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Pnpt1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Pnpt1tm1a(KOMP)Wtsi HOM Female Male n/a 0.0
increased mean corpuscular volume Pnpt1tm1a(KOMP)Wtsi HET Male postnatal 7.95E-16
abnormal clavicle morphology Pnpt1tm1a(KOMP)Wtsi HET Female postnatal 4.35E-6
increased mean corpuscular hemoglobin Pnpt1tm1a(KOMP)Wtsi HET Male postnatal 4.28E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (1/2)
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540) (1/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No (1/2)
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (1/2)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system endocrine system nervous system set of connective tissues reproductive system musculoskeletal system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (7)
  • Pnpt1tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    TRACHEA, THYROID GLAND, PARATHYROID GLAND, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    KIDNEY, HET, Male, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    OVIDUCT, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    SPLEEN, HET, Male, WTSI

show all 7 images

nervous system (3)
  • Pnpt1tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Male, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    SPINAL CORD, HET, Female, WTSI
reproductive system (3)
  • Pnpt1tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    OVIDUCT, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    PLACENTA, HET, Unsexed, WTSI
endocrine system (2)
  • Pnpt1tm1a(KOMP)Wtsi
    TRACHEA, THYROID GLAND, PARATHYROID GLAND, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    ADRENAL GLAND, HET, Male, WTSI
immune system (1)
  • Pnpt1tm1a(KOMP)Wtsi
    SPLEEN, HET, Male, WTSI
musculoskeletal system (1)
  • Pnpt1tm1a(KOMP)Wtsi
    SKELETAL MUSCLE TISSUE, HET, Female, WTSI
respiratory system (1)
  • Pnpt1tm1a(KOMP)Wtsi
    TRACHEA, THYROID GLAND, PARATHYROID GLAND, HET, Female, WTSI
urinary system (1)
  • Pnpt1tm1a(KOMP)Wtsi
    KIDNEY, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (148)
  • Pnpt1tm1a(KOMP)Wtsi
    WT, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    WT, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    WT, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    WT, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    TRUNK, HET, Female, WTSI

show all 148 images

Skin Histopathology (5)
  • Pnpt1tm1a(KOMP)Wtsi
    FOOT DIGIT 4, WT, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Pnpt1tm1a(KOMP)Wtsi
    FOOT DIGIT 4, WT, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Pnpt1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Pnpt1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Pnpt1tm301213(L1L2_Bact_P)
Vector
Gene
Pnpt1tm37613(L1L2_Pgk_P)
Vector
Gene