Gene: Aph1c

Name aph1 homolog C, gamma secretase subunit

Synonyms 0610008A10Rik

Status ES CellsMice
tm1a
Mice
tm1b
Mice
tm1c
phenotype data available

Links MGI:1915568   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Aph1c

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Aph1c data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal coat/hair pigmentation Aph1ctm1b(KOMP)Wtsi HOM Male postnatal 4.7E-12

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354)
Aorta 2 No (2/530)
Bone 2 No (1/515)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530)
Cerebellum 2 No (6/530)
Cerebral cortex 2 No (6/530) (2/2)
Esophagus 2 No (1/354)
Eye 2 No (1/530)
Gall bladder 2 No
Heart 2 No (4/530)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529) (2/2)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530)
Liver 2 No
Lower urinary tract 2 No (3/530)
Lung 2 No (4/530)
Lymph node 2 No (2/530)
Mammary gland 2 No
Olfactory lobe 2 No (3/354) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/530)
Oviduct 2 No (1/530)
Pancreas 2 No (2/530)
Parathyroid gland 2 No (2/516)
Peripheral nervous system 2 No (4/530)
Peyer's patch 2 No (1/354)
Pituitary gland 2 No (2/530)
Prostate gland 2 No (3/530)
Skeletal muscle 2 No
Skin 2 No (2/530)
Small intestine 2 No (5/530)
Spinal cord 2 No (5/530)
Spleen 2 No (3/530)
Stomach 2 No (5/530)
Striatum 2 No (6/530) (2/2)
Testis 2 No (7/530) (1/2)
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530)
Trachea 2 No (5/530)
Uterus 2 No (1/530)
Vascular system 2 No (1/354)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    nervous system
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (5/413)
Ear 2
Embryo 2
Eye 2
Foot 2
Forebrain 2
Forelimb 2
Hand 2
Head 2 (4/413)
Heart 2
Hindbrain 2 (5/413)
Hindlimb 2
Liver 2
Lung 2
Mandibular process 2
Maxillary process 2
Midbrain 2
Oral cavity 2
Skin 2
Tail 2
Tail somite 2


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Adult LacZ: LacZ Images Wholemount
    5 Images
  • Echo: M-Mode Images
    24 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Aph1ctm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Aph1ctm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Aph1ctm1c(KOMP)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene