Gene: Med28

Order

Name mediator complex subunit 28

Synonyms
  • magicin
  • 1500003D12Rik
  • Eg1

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1914249    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Med28

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Med28 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Med28tm1.1(KOMP)Vlcg HET Female Male embryonic day 9.5 0.0
abnormal spleen morphology Med28tm1.1(KOMP)Vlcg HET Male postnatal 0.0
embryonic lethality prior to organogenesis Med28tm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Med28tm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Med28tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
small spleen Med28tm1.1(KOMP)Vlcg HET Male postnatal 0.0
increased or absent threshold for auditory brainstem response Med28tm1.1(KOMP)Vlcg HET Female Male postnatal 2.9E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415) (3/4)
Aorta 4 No
Blood 4 No
Bone marrow 4 No
Brain 4 No (2/4)
Brainstem 4 No
Brown adipose tissue 4 No
Cartilage tissue 4 No
Cecum 4 No (12/383) (3/4)
Cerebellum 4 No (4/4)
Cerebral cortex 4 No
Chest bone 4 No (2/4)
Colon 4 No (12/127) (3/4)
Diaphragm 4 No
Duodenum 4 No (2/127) (1/4)
Epididymis 4 No (18/134) (2/4)
Esophagus 4 No (7/415)
Eye 4 No (2/4)
Gall bladder 4 No
Gonadal fat pad 4 No
Harderian gland 4 No (2/4)
Heart 4 No
Hindlimb 4 No
Hippocampus 4 No
Hypothalamus 4 No
Ileum 4 No (14/127) (3/4)
Jejunum 4 No (6/127) (2/4)
Kidney 4 No (18/584) (4/4)
Large intestine 4 No (10/584)
Liver 4 No (4/4)
Lower urinary tract 4 No
Lung 4 No
Lymph node 4 No
Mammary gland 4 No
Mesenteric lymph node 4 No
Mesenteric adipose tissue 4 No
Midbrain 4 No (4/4)
Olfactory lobe 4 No (4/4)
Ovary 4 No (1/584)
Oviduct 4 No
Pancreas 4 No (5/584) (2/4)
Parathyroid gland 4 No
Parotid gland 4 No
Penis 4 No
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No (3/4)
Prostate gland 4 No (12/584) (1/4)
Quadriceps 4 No (1/4)
Sciatic nerve 4 No
Skeletal muscle 4 No
Skin 4 No
Small intestine 4 No (9/584)
Spinal cord 4 No (3/4)
Spleen 4 No (2/584)
Stomach 4 No (12/584) (4/4)
Stomach pyloric region 4 No
Striatum 4 No
Sublingual gland 4 No (1/4)
Submandibular gland 4 No (2/132)
Testis 4 No (2/584) (2/4)
Thymus 4 No (1/4)
Thyroid gland 4 No (15/584) (1/4)
Tongue 4 No (5/127) (2/4)
Trachea 4 No (3/4)
Trigeminal V nerve 4 No
Urinary bladder 4 No (3/4)
Uterus 4 No (1/4)
Vagina 4 No
Vas deferens 4 No (15/388) (2/4)
Vascular system 4 No
Vesicular gland 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system respiratory system digestive system nervous system sensory organ reproductive system musculoskeletal system immune system exocrine system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2 (1/51)
Brain 7 (6/485)
Central nervous system ganglion 2 (1/51)
Ear 7 (1/485)
Embryo 7 (1/485) (2/7)
Eye 7 (1/485) (2/7)
Foot 7 (1/485)
Forebrain 7 (1/485)
Forelimb 7 (1/485) (2/7)
Gut 2 (1/50)
Hand 7 (1/485)
Head 7 (5/485)
Heart 7 (1/485) (2/7)
Hindbrain 7 (6/485)
Hindlimb 7 (1/485) (2/7)
Liver 7 (1/485)
Lung 7 (1/485)
Mandibular process 7 (1/485) (2/7)
Maxillary process 7 (1/485) (2/7)
Midbrain 7 (1/485)
Nose 2 (1/51)
Oral cavity 7 (1/485) Image Only
Skeleton 2 (1/51) (2/2)
Skin 7 (1/485)
Spinal cord 2 (1/50)
Tail 7 (1/485)
Tail somite 7 (1/485)
Trachea 2 (1/50)
Urinary system 2 (1/50) (2/2)


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    20 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Med28tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Med28tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Med28tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue