Gene: Ncbp3 MGI:1914124
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, incomplete penetrance | Ncbp3tm1b(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
decreased lean body mass | Ncbp3tm1b(EUCOMM)Wtsi | HET | Early adult | 2.04×10-05 | ||
enlarged heart | Ncbp3tm1b(EUCOMM)Wtsi | HET | Early adult | 0.00 | ||
increased total body fat amount | Ncbp3tm1b(EUCOMM)Wtsi | HET | Early adult | 5.47×10-05 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Wholemount images | heterozygote | 100% (2 of 2) |
Aorta | Wholemount images | heterozygote | 100% (2 of 2) |
Bone | Wholemount images | heterozygote | 100% (2 of 2) |
Brain | Wholemount images | heterozygote | 100% (2 of 2) |
Brainstem | Wholemount images | heterozygote | 100% (2 of 2) |
Cartilage tissue | Wholemount images | heterozygote | 100% (2 of 2) |
Cerebellum | Wholemount images | heterozygote | 100% (2 of 2) |
Cerebral cortex | Wholemount images | heterozygote | 100% (2 of 2) |
Esophagus | Wholemount images | heterozygote | 100% (2 of 2) |
Eye | Wholemount images | heterozygote | 100% (2 of 2) |
Gall bladder | Wholemount images | heterozygote | 100% (2 of 2) |
Heart | Wholemount images | heterozygote | 100% (2 of 2) |
Hippocampus | Wholemount images | heterozygote | 100% (2 of 2) |
Hypothalamus | Wholemount images | heterozygote | 100% (2 of 2) |
Kidney | Wholemount images | heterozygote | 100% (2 of 2) |
Large intestine | Wholemount images | heterozygote | 100% (2 of 2) |
Lower urinary tract | Wholemount images | heterozygote | 100% (2 of 2) |
Lung | Wholemount images | heterozygote | 100% (2 of 2) |
Lymph node | Wholemount images | heterozygote | 100% (2 of 2) |
Olfactory lobe | Wholemount images | heterozygote | 100% (2 of 2) |
Ovary | Wholemount images | heterozygote | 50% (1 of 2) |
Oviduct | Wholemount images | heterozygote | 50% (1 of 2) |
Pancreas | Wholemount images | heterozygote | 100% (2 of 2) |
Parathyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
Peripheral nervous system | Wholemount images | heterozygote | 100% (2 of 2) |
Peyer's patch | Wholemount images | heterozygote | 100% (2 of 2) |
Pituitary gland | Wholemount images | heterozygote | 100% (2 of 2) |
Prostate gland | Wholemount images | heterozygote | 0.0% (0 of 2) |
Skeletal muscle | Wholemount images | heterozygote | 100% (2 of 2) |
Skin | Wholemount images | heterozygote | 100% (2 of 2) |
Small intestine | Wholemount images | heterozygote | 100% (2 of 2) |
Spinal cord | Wholemount images | heterozygote | 100% (2 of 2) |
Stomach | Wholemount images | heterozygote | 100% (2 of 2) |
Striatum | Wholemount images | heterozygote | 100% (2 of 2) |
Testis | Wholemount images | heterozygote | 50% (1 of 2) |
Thymus | Wholemount images | heterozygote | 100% (2 of 2) |
Thyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
Trachea | Wholemount images | heterozygote | 100% (2 of 2) |
Uterus | Wholemount images | heterozygote | 50% (1 of 2) |
Vascular system | Wholemount images | heterozygote | 100% (2 of 2) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Oral epithelium | N/A | heterozygote | 0.0% (0 of 2) |
Spleen | N/A | heterozygote | 0.0% (0 of 2) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | N/A | heterozygote | 100% (1 of 1) |
Brain | N/A | homozygote | 100% (1 of 1) |
Ear | N/A | heterozygote | Not available |
Ear | N/A | homozygote | Not available |
Embryo | N/A | heterozygote | 100% (1 of 1) |
Embryo | N/A | homozygote | 100% (1 of 1) |
Eye | N/A | heterozygote | 100% (1 of 1) |
Eye | N/A | homozygote | 100% (1 of 1) |
Footplate | N/A | heterozygote | 100% (1 of 1) |
Footplate | N/A | homozygote | 100% (1 of 1) |
Forebrain | N/A | heterozygote | 100% (1 of 1) |
Forebrain | N/A | homozygote | 100% (1 of 1) |
Forelimb | N/A | heterozygote | 100% (1 of 1) |
Forelimb | N/A | homozygote | 100% (1 of 1) |
Handplate | N/A | heterozygote | 100% (1 of 1) |
Handplate | N/A | homozygote | 100% (1 of 1) |
Head | N/A | heterozygote | 100% (1 of 1) |
Head | N/A | homozygote | 100% (1 of 1) |
Heart | N/A | heterozygote | Not available |
Heart | N/A | homozygote | Not available |
Hindbrain | N/A | heterozygote | 100% (1 of 1) |
Hindbrain | N/A | homozygote | 100% (1 of 1) |
Hindlimb | N/A | heterozygote | 100% (1 of 1) |
Hindlimb | N/A | homozygote | 100% (1 of 1) |
Liver | N/A | heterozygote | Not available |
Liver | N/A | homozygote | Not available |
Lung | N/A | heterozygote | Not available |
Lung | N/A | homozygote | Not available |
Mandibular process | N/A | heterozygote | Not available |
Mandibular process | N/A | homozygote | Not available |
Maxillary process | N/A | heterozygote | Not available |
Maxillary process | N/A | homozygote | Not available |
Midbrain | N/A | heterozygote | 100% (1 of 1) |
Midbrain | N/A | homozygote | 100% (1 of 1) |
Oral cavity | N/A | heterozygote | Not available |
Oral cavity | N/A | homozygote | Not available |
Skin | N/A | heterozygote | Not available |
Skin | N/A | homozygote | Not available |
Tail somite | N/A | heterozygote | 100% (1 of 1) |
Tail somite | N/A | homozygote | 100% (1 of 1) |
Tail | N/A | heterozygote | 100% (1 of 1) |
Tail | N/A | homozygote | 100% (1 of 1) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
bone | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
olfactory lobe | 0.0% |
oral epithelium | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
uterus | 0.0% |
vascular system | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 0.0% |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
oral cavity | 0.0% |
skin | 0.0% |
tail | 0.0% |
tail somite group | 0.0% |
Human diseases caused by Ncbp3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Ncbp3 by phenotypic similarity.
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ncbp3.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Interferon-λ Receptor Expression: Novel Reporter Mouse Reveals Within- and Cross-Tissue Heterogeneity. | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (May 2020) | Ncbp3tm1a(EUCOMM)Wtsi | 32364818 |
The alternative cap-binding complex is required for antiviral defense in vivo. | PLoS pathogens (December 2019) | Ncbp3tm1a(EUCOMM)Wtsi | PMC6946169 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Ncbp3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Ncbp3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Ncbp3tm331(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Ncbp3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Ncbp3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
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