Gene: Duoxa2

Order

Name dual oxidase maturation factor 2

Synonyms
  • Nip2
  • 9030623N16Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1914061    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Duoxa2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Duoxa2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal bone structure Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased B cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased B-2 B cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased CD11b-high dendritic cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased KLRG1-positive NK cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased body length Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased effector memory T-helper cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased follicular B cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased immature B cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased mature B cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased memory-marker gamma-delta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased transitional stage T1 B cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased CD4-positive, alpha beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased CD8-positive, naive alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased T-helper cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased effector memory CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased or absent threshold for auditory brainstem response Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased plasmacytoid dendritic cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
prenatal lethality prior to heart atrial septation Duoxa2tm1b(KOMP)Wtsi HOM Female Male embryonic day 14.5 0.0
increased mean corpuscular hemoglobin Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.43E-37
decreased erythrocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 6.03E-22
abnormal vertebral arch morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.65E-19
abnormal zygomatic bone morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.67E-19
abnormal clavicle morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.7E-19
abnormal tibia morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.7E-19
abnormal humerus morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.92E-18
absent pinna reflex Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 4.56E-18
abnormal femur morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 4.44E-17
abnormal ulna morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 4.44E-17
abnormal radius morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.22E-16
decreased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 5.89E-16
abnormal joint morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 6.36E-16
decreased bone mineral content Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.27E-15
decreased grip strength Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 8.99E-15
abnormal thoracic cage shape Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.18E-14
decreased leukocyte cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.31E-13
abnormal cranium morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.05E-12
decreased bone mineral density Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.54E-11
abnormal snout morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.06E-11
decreased heart weight Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 5.54E-11
decreased total body fat amount Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.13E-10
abnormal vertebrae morphology Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.59E-10
decreased hematocrit Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.24E-9
decreased red blood cell distribution width Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 3.14E-9
decreased food intake Duoxa2tm1b(KOMP)Wtsi HOM Male postnatal 2.59E-8
decreased mean platelet volume Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 5.04E-8
abnormal eyelid morphology Duoxa2tm1b(KOMP)Wtsi HOM Female postnatal 1.32E-7
decreased hemoglobin content Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.39E-7
abnormal hair growth Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 6.64E-7
decreased Ly6C low monocyte number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.0E-6
decreased caudal vertebrae number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.2E-6
increased lean body mass Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.52E-6
abnormal head morphology Duoxa2tm1b(KOMP)Wtsi HOM Male postnatal 1.04E-5
increased neutrophil cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.42E-5
decreased NK cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.58E-5
increased CD8-positive, alpha-beta T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.75E-5
increased mean corpuscular hemoglobin concentration Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.8E-5
decreased NK T cell number Duoxa2tm1b(KOMP)Wtsi HOM Female Male postnatal 6.82E-5
thrombocytopenia Duoxa2tm1b(KOMP)Wtsi HOM Male postnatal 8.34E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No (2/2)
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse digestive system reproductive system immune system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (5)
  • Duoxa2tm1b(KOMP)Wtsi
    SMALL INTESTINE, HET, Female, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    GALL BLADDER, HET, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    GALL BLADDER, HET, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    SMALL INTESTINE, HET, Male, WTSI
digestive system (4)
  • Duoxa2tm1b(KOMP)Wtsi
    SMALL INTESTINE, HET, Female, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    GALL BLADDER, HET, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    GALL BLADDER, HET, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    SMALL INTESTINE, HET, Male, WTSI
reproductive system (1)
  • Duoxa2tm1b(KOMP)Wtsi
    TESTIS, HET, Male, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • Eye Morphology: Images Slit Lamp
    2 Images
  • X-ray: XRay Images Dorso Ventral
    42 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • Eye Morphology: Images Ophthalmoscopy
    1 Images
  • Anti-nuclear antibody assay
    6 Images
  • Ear epidermis immunophenotyping
    12 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (70)
  • Duoxa2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    HOM, Male, WTSI

show all 70 images

Dysmorphology (24)
  • Duoxa2tm1b(KOMP)Wtsi
    proportional dwarfism, HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    proportional dwarf, HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    HEAD, abnormal snout morphology, malocclusion, HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    short snout, HEAD, abnormal snout morphology, HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    proportional dwarf, HOM, Male, WTSI

show all 24 images

Brain Histopathology (4)
  • Duoxa2tm1b(KOMP)Wtsi
    decreased brain internal capsule size, INTERNAL CAPSULE, HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    INTERNAL CAPSULE, decreased brain internal capsule size, HOM, Male, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    decreased brain internal capsule size, INTERNAL CAPSULE, HOM, Male, WTSI
Eye Morphology (3)
  • Duoxa2tm1b(KOMP)Wtsi
    abnormal retinal pigmentation, HOM, Female, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    small pupils, HOM, Female, WTSI
  • Duoxa2tm1b(KOMP)Wtsi
    small pupils, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Duoxa2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Duoxa2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene