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Gene: Dync2li1 MGI:1913996

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
dynein cytoplasmic 2 light intermediate chain 1
Synonyms:
LIC3,  4933404O11Rik,  CGI-60,  D2lic,  mD2LIC

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dync2li1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dync2li1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ellis Van Creveld Syndrome
Ventricular septal defect, Dextrocardia, Abnormal heart valve morphology, Situs inversus totalis,... ORPHA:289
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Patent ductus arteriosus, Atrioventricular canal defect, Polyhydramnios OMIM:617088
Jeune Syndrome
ORPHA:474

The table below shows human diseases predicted to be associated to Dync2li1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Frontal Encephalocele
Encephalocele, Hydrocephalus, Spina bifida ORPHA:1931
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida, Mitral valve prolapse OMIM:211960
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Ventricular septal defect, Hypoplastic left heart, Anencephaly, Spina bifida ORPHA:2476
Thoraco-Abdominal Enteric Duplication
Meningocele, Abnormal tricuspid valve morphology, Dextrocardia ORPHA:1759
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Isolated Hemihyperplasia
Cryptorchidism, Myelomeningocele ORPHA:2128
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Myelomeningocele, Anencephaly OMIM:182940
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Congenital Vertical Talus
Myelomeningocele ORPHA:178382
Subependymal Nodular Heterotopia
Occipital encephalocele, Myelomeningocele, Meningocele, Nasofrontal encephalocele ORPHA:101030
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Ventricular septal defect, Situs inversus totalis, Hydrocephalus, Meningocele, Ane... ORPHA:1908
Meckel Syndrome, Type 4
Encephalocele, Ventricular septal defect, Hydrocephalus, Meningocele, Anencephaly, Atrial septal ... OMIM:611134
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Wildervanck Syndrome
Meningocele ORPHA:3456
Isolated Klippel-Feil Syndrome
Ventricular septal defect, Spina bifida ORPHA:2345
Humero-Radial Synostosis
Meningocele ORPHA:3265
Chiari Malformation Type Ii
Cervical myelopathy, Myelomeningocele, Hydrocephalus, Spina bifida OMIM:207950
Schisis Association
Encephalocele, Anencephaly, Spina bifida ORPHA:63862
Caudal Duplication
Cryptorchidism, Myelomeningocele, Spina bifida ORPHA:1756
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Bicuspid aortic valve, Spina bifida, Patent ductus arteriosus, Anomalous pulmonary venous return,... ORPHA:1120
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Diaphanospondylodysostosis
Myelomeningocele ORPHA:66637
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Triploidy
Polyhydramnios, Cryptorchidism, Hydrocephalus, Meningocele, Abnormal cardiac septum morphology, H... ORPHA:3376
Sirenomelia
Spina bifida, Sirenomelia ORPHA:3169
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Hydromyelia, Occipital meni... ORPHA:268810
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Meckel Syndrome, Type 2
Encephalocele, Meningocele, Anencephaly OMIM:603194
Czeizel-Losonci Syndrome
Dextrocardia, Spina bifida, Myelomeningocele, Hydrocephalus, Spina bifida occulta ORPHA:2437
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Alg3-Cdg
Neural tube defect, Cardiomyopathy ORPHA:79321
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Joubert Syndrome 14
Encephalocele, Hydrocephalus, Meningocele, Ventricular septal defect OMIM:614424
Enlarged Parietal Foramina
Occipital encephalocele, Myelomeningocele ORPHA:60015
Fountain Syndrome
Facial edema, Spina bifida occulta, Spina bifida ORPHA:3219
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Autosomal Recessive Spondylocostal Dysostosis
Cryptorchidism, Meningocele, Anomalous pulmonary venous return, Umbilical hernia, Spina bifida oc... ORPHA:2311
Neurocutaneous Melanocytosis
Meningocele ORPHA:2481
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract, Hydromyelia OMIM:600145
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Neu-Laxova Syndrome 2
Polyhydramnios, Spina bifida, Edema OMIM:616038
Iniencephaly
Encephalocele, Spina bifida, Polyhydramnios, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal... ORPHA:63259
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Mosaic Trisomy 9
Ventricular septal defect, Dextrocardia, Polyhydramnios, Spina bifida, Abnormal heart valve morph... ORPHA:99776
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Cerebrocostomandibular Syndrome
Ventricular septal defect, Spina bifida, Myelomeningocele, Meningocele, Hydranencephaly ORPHA:1393
Lateral Meningocele Syndrome
Bicuspid aortic valve, Ventricular septal defect, Cryptorchidism, Hydrocephalus, Meningocele, Pat... OMIM:130720
Spondylocostal Dysostosis 4, Autosomal Recessive
Dextrocardia, Situs inversus totalis, Myelomeningocele, Hydrocephalus, Spina bifida occulta OMIM:613686
Lateral Meningocele Syndrome
Umbilical hernia, Meningocele, Ventricular septal defect, Cryptorchidism ORPHA:2789
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida ORPHA:2839
Acromelic Frontonasal Dysplasia
Encephalocele, Cryptorchidism, Meningocele ORPHA:1827
Phakomatosis Pigmentokeratotica
Cryptorchidism, Spina bifida, Lymphedema ORPHA:2874
Limb Body Wall Complex
Encephalocele, Ventricular septal defect, Spina bifida, Myelomeningocele, Hydrocephalus, Anenceph... ORPHA:2369
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Polyhydramnios, Hydrocephalus, Anencephaly, Hydrops fetalis, Atrial septal defect, Occipital meni... OMIM:616546
Chromosome 17P13.1 Deletion Syndrome
Spina bifida, Hydrocephalus, Hydrocele testis, Umbilical hernia, Oligohydramnios OMIM:613776
Vacterl With Hydrocephalus
Polyhydramnios, Spina bifida, Aqueductal stenosis, Cryptorchidism, Hydrocephalus ORPHA:3412
Heterotaxy, Visceral, 1, X-Linked
Polyhydramnios, Cardiomegaly, Aqueductal stenosis, Dextrotransposition of the great arteries, Atr... OMIM:306955
Pagod Syndrome
Encephalocele, Spina bifida, Situs inversus totalis, Meningocele, Hypoplastic left heart, Abnorma... ORPHA:991
Trisomy 18
Ventricular septal defect, Spina bifida, Cryptorchidism, Anencephaly, Holoprosencephaly, Atrial s... ORPHA:3380
Lumbar Syndrome
Cryptorchidism, Myelomeningocele, Spina bifida ORPHA:83628
Fibular Hemimelia
Spina bifida, Abnormal heart morphology ORPHA:93323
Trisomy 20P
Macroorchidism, Umbilical hernia, Spina bifida, Cryptorchidism ORPHA:261318
Basal Cell Nevus Syndrome 1
Cardiac rhabdomyoma, Hydrocephalus, Cardiac fibroma, Spina bifida OMIM:109400
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Focal Dermal Hypoplasia
Ventricular septal defect, Spina bifida, Patent ductus arteriosus, Abnormal cardiac septum morpho... ORPHA:2092
Curry-Jones Syndrome
Occipital meningocele, Lipomyelomeningocele OMIM:601707
Neu-Laxova Syndrome 1
Ventricular septal defect, Polyhydramnios, Spina bifida, Cryptorchidism, Patent ductus arteriosus... OMIM:256520
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Phocomelia, Schinzel Type
Cryptorchidism, Meningocele, Hydrops fetalis ORPHA:2879
Nail-Patella Syndrome
Spina bifida OMIM:161200
Neu-Laxova Syndrome
Polyhydramnios, Spina bifida ORPHA:2671
Lathosterolosis
Meningocele ORPHA:46059
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele ORPHA:397715
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Bicuspid aortic valve, Truncus arteriosus, Spina bifida, Ventricular septal defect, Perimembranou... ORPHA:508498
Orofaciodigital Syndrome Vi
Occipital meningocele, Hypoplastic left heart OMIM:277170
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Thrombocytopenia-Absent Radius Syndrome
Edema of the dorsum of feet, Ventricular septal defect, Spina bifida, Edema of the dorsum of hand... OMIM:274000
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Patent ductus arteriosus, Atrioventricular canal defect, Spina bifida OMIM:619480
Fanconi Anemia
Spina bifida, Cryptorchidism, Hydrocephalus, Patent ductus arteriosus, Azoospermia, Abnormal card... ORPHA:84
22Q11.2 Deletion Syndrome
Ventricular septal defect, Abnormal pulmonary valve morphology, Spina bifida, Polyhydramnios, Cry... ORPHA:567
Holoprosencephaly 7
Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosencephaly, Occipital me... OMIM:610828
Split Cord Malformation
Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Meningocele, Hydrocephalus, Hydrom... ORPHA:573278
Hallermann-Streiff Syndrome
Cryptorchidism, Spina bifida OMIM:234100
Jacobsen Syndrome
Ventricular septal defect, Spina bifida, Cryptorchidism, Hypoplastic left heart, Aortic valve ste... ORPHA:2308
Koolen-De Vries Syndrome Due To A Point Mutation
Bicuspid aortic valve, Ventricular septal defect, Spina bifida, Testicular neoplasm, Cryptorchidi... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Bicuspid aortic valve, Ventricular septal defect, Spina bifida, Testicular neoplasm, Cryptorchidi... ORPHA:363958
Vater/Vacterl Association
Occipital encephalocele, Ventricular septal defect, Spina bifida, Patent ductus arteriosus, Trans... OMIM:192350
Campomelic Dysplasia
Polyhydramnios, Spina bifida, Hydrocephalus, Abnormal heart morphology, Spinal dysraphism OMIM:114290
Knobloch Syndrome 1
Occipital meningocele, Occipital encephalocele, Patent ductus arteriosus, Spina bifida occulta OMIM:267750
Aicardi Syndrome
Spina bifida OMIM:304050
Rubinstein-Taybi Syndrome 1
Ventricular septal defect, Spina bifida, Polyhydramnios, Bilateral cryptorchidism, Cryptorchidism... OMIM:180849
Marfan Syndrome
Mitral valve calcification, Meningocele, Mitral valve prolapse ORPHA:558
Exstrophy-Epispadias Complex
Cryptorchidism, Hydrocephalus, Spina bifida, Abnormal heart morphology ORPHA:322
Semilobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:220386
Alobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:93924
Arima Syndrome
Occipital meningocele OMIM:243910
Otopalatodigital Syndrome, Type Ii
Spina bifida, Cryptorchidism, Hydrocephalus, Stillbirth, Atrial septal defect, Umbilical hernia OMIM:304120
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele, Cryptorchidism OMIM:276820
Ellis Van Creveld Syndrome
Ventricular septal defect, Dextrocardia, Abnormal heart valve morphology, Situs inversus totalis,... ORPHA:289
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Patent ductus arteriosus, Atrioventricular canal defect, Polyhydramnios OMIM:617088
Jeune Syndrome
ORPHA:474

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dync2li1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dync2li1.

No publications found that use IMPC mice or data for Dync2li1.

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