Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tbc1d15.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. | Experimental & molecular medicine (February 2024) | Tbc1d15tm1c(KOMP)Wtsi | PMC10907578 |
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. | Nature communications (June 2020) | Tbc1d15tm1c(KOMP)Wtsi Tbc1d15tm1a(KOMP)Wtsi | PMC7299990 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Tbc1d15tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Tbc1d15tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Tbc1d15tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Tbc1d15tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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