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Genes Phenotypes Help, News, Blog

Gene: Emc3 MGI:1913337

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Gene Summary

Name:
ER membrane protein complex subunit 3
Synonyms:
Tmem111,  0610039A15Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Emc3tm1b(EUCOMM)Wtsi HET Early adult 3.89×10-05
preweaning lethality, complete penetrance Emc3tm1b(EUCOMM)Wtsi HOM   Early adult 4.24×10-05
increased bone mineral content Emc3tm1b(EUCOMM)Wtsi HET Early adult 1.61×10-05
decreased vertical activity Emc3tm1b(EUCOMM)Wtsi HET   Early adult 1.51×10-05
increased total body fat amount Emc3tm1b(EUCOMM)Wtsi HET Early adult 1.59×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Electrocardiogram (ECG)

Waveform Image

30 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Emc3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Emc3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Emc3.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. iScience (November 2022) Emc3tm1c(EUCOMM)Wtsi PMC9823123
Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal immunology (March 2021) Emc3tm1a(EUCOMM)Wtsi PMC8222001
EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Investigative ophthalmology & visual science (February 2021) Emc3tm1a(EUCOMM)Wtsi PMC7900856
EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. The Journal of clinical investigation (October 2017) Emc3tm1a(EUCOMM)Wtsi PMC5707157

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Emc3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Emc3tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Emc3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Emc3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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