banner
Genes Phenotypes Help, News, Blog

Gene: Ndufb5 MGI:1913296

Log in to follow

Gene Summary

Name:
NADH:ubiquinone oxidoreductase subunit B5
Synonyms:
0610007D05Rik

Order Alleles

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Ndufb5em1(IMPC)Bay HOM   E12.5 0.00
abnormal embryo size Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo turning Ndufb5em1(IMPC)Bay HOM E9.5 0.00
embryonic growth retardation Ndufb5em1(IMPC)Bay HET E9.5 0.00
abnormal heart morphology Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal forebrain development Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal neural tube closure Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal midbrain development Ndufb5em1(IMPC)Bay HOM E9.5 0.00
embryonic growth retardation Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal neural tube morphology Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal allantois morphology Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal heart looping Ndufb5em1(IMPC)Bay HOM E9.5 0.00
abnormal tail bud morphology Ndufb5em1(IMPC)Bay HOM E9.5 0.00
preweaning lethality, complete penetrance Ndufb5em1(IMPC)Bay HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Download thumbnail Download
MicroCT E9.5

Embryo reconstruction

2 Images

View images

Human diseases caused by Ndufb5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ndufb5 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Finger Locking, Recurrent, With Intrauterine Growth Retardation And Proportionate Short Stature
Intrauterine growth retardation, Short stature OMIM:135950
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Hypoplastic left heart, Ventricular septal defect, Spina bifida ORPHA:2476
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Ventricular septal defect, Short stature, Situs inversus totalis, Hydrocephalus, M... ORPHA:1908
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Short stature, Spinal dysraphism, Hypoplastic left heart, Aortic valve stenosis, Atrial septal de... OMIM:617660
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract OMIM:600145
Iniencephaly
Encephalocele, Rhizomelia, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dys... ORPHA:63259
Semilobar Holoprosencephaly
Short stature, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Short stature, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Short stature, Hydrocephalus, Abnormal heart morphology, Growth delay, Neural tube defect ORPHA:93924
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Schinzel-Giedion Syndrome
Neural tube defect, Umbilical hernia, Abnormal heart morphology ORPHA:798

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ndufb5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ndufb5.

No publications found that use IMPC mice or data for Ndufb5.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ndufb5tm402102(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ndufb5em1(IMPC)Bay Exon Deletion Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter