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Gene: Trem2 MGI:1913150

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
triggering receptor expressed on myeloid cells 2
Synonyms:
Trem2a,  Trem2b,  Trem2c

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Trem2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Trem2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Nasu-Hakola Disease
Acute leukemia ORPHA:2770
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2
OMIM:618193
Semantic Dementia
ORPHA:100069
Early-Onset Autosomal Dominant Alzheimer Disease
ORPHA:1020
Behavioral Variant Of Frontotemporal Dementia
ORPHA:275864
Progressive Non-Fluent Aphasia
ORPHA:100070
Amyotrophic Lateral Sclerosis
ORPHA:803

The table below shows human diseases predicted to be associated to Trem2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Histiocytosis, Progressive Mucinous
Mucinous histiocytosis OMIM:142630
Neutropenia-Monocytopenia-Deafness Syndrome
Abnormal macrophage morphology, Abnormality of neutrophils ORPHA:2690
Histiocytosis, Familial Lipochrome
Increased alpha-globulin, Increased circulating antibody level, Histiocytosis OMIM:235900
Undritz Anomaly
Hypersegmentation of neutrophil nuclei OMIM:191500
Benign Cephalic Histiocytosis
Histiocytosis ORPHA:157997
Neutropenia, Severe Congenital, 2, Autosomal Dominant
Monocytosis, B lymphocytopenia, Neutropenia OMIM:613107
Hemophagocytic Lymphohistiocytosis, Familial, 3
Hypertriglyceridemia, Reduced natural killer cell activity, Hepatosplenomegaly, Hemophagocytosis,... OMIM:608898
Papular Xanthoma
Histiocytosis ORPHA:158008
X-Linked Severe Congenital Neutropenia
Monocytopenia, Neutropenia ORPHA:86788
Lymphoproliferative Syndrome, X-Linked, 2
Pancytopenia, Hypertriglyceridemia, Acne, Recurrent skin infections, Aplastic anemia, Erythema no... OMIM:300635
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Hypertriglyceridemia, Increased circulating ferritin concentration, Splenomegaly, Abnormal natura... OMIM:613101
Gaisböck Syndrome
Hypertriglyceridemia, Angina pectoris, Diabetes mellitus, Myocardial infarction, Splenomegaly, Hy... ORPHA:90041
Marburg Hemorrhagic Fever
Elevated circulating creatine kinase concentration, Uveitis, Leukopenia, Hypoalbuminemia, Abnorma... ORPHA:99826
Lymphoproliferative Syndrome, X-Linked, 1
Pancytopenia, Aplastic anemia, Dysgammaglobulinemia, Elevated circulating C-reactive protein conc... OMIM:308240
Immunodeficiency 11A
Decreased proportion of CD4+CD25+ regulatory T cells, Decreased circulating antibody level, Agamm... OMIM:615206
Colchicine Poisoning
Hyponatremia, Myocarditis, Congestive heart failure, Leukocytosis, Hypovolemia, Abnormal blood io... ORPHA:31824
Ataxia-Pancytopenia Syndrome
Pancytopenia, Abnormal macrophage morphology, Abnormality of neutrophils, Splenomegaly, Acute mye... ORPHA:2585
Immunodeficiency 97 With Autoinflammation
Decreased proportion of CD8-positive, alpha-beta TEMRA T cells, Colitis, Decreased circulating Ig... OMIM:619802
Immunodeficiency 27A
Increased inflammatory response, Pneumonia, Splenomegaly, Leukocytosis, Hepatosplenomegaly, Incre... OMIM:209950
Familial Hypoaldosteronism
Hyponatremia, Orthostatic hypotension, Hyperkalemia, Hypovolemia, Increased circulating renin lev... ORPHA:427
Cocaine Intoxication
Prolonged QT interval, Tachycardia, Prolonged QRS complex, Glomerulonephritis, Myocardial infarct... ORPHA:90068
Immunodeficiency 98 With Autoinflammation, X-Linked
Autoimmune hemolytic anemia, Splenomegaly, Neutropenia, Type I diabetes mellitus, Bone marrow hyp... OMIM:301078
Acute Adrenal Insufficiency
Hyponatremia, Normocytic anemia, Orthostatic hypotension, Hypoglycemia, Hypercalcemia, Myocardial... ORPHA:95409
Leishmaniasis
Pancytopenia, Abnormal macrophage morphology, Thrombocytopenia, Splenomegaly, Leukopenia, Rhiniti... ORPHA:507
Lysosomal Acid Lipase Deficiency
Hyponatremia, Hypertriglyceridemia, Hypercholesterolemia, Bone-marrow foam cells, Hypersplenism, ... ORPHA:275761
Nephrogenic Diabetes Insipidus
Hypernatremia, Hypovolemia ORPHA:223
Juvenile Nephropathic Cystinosis
Hyponatremia, Hypouricemia, Hypovolemia, Elevated circulating creatinine concentration, Glycosuri... ORPHA:411634
Familial Thoracic Aortic Aneurysm And Aortic Dissection
Aortic regurgitation, Transient ischemic attack, Subarachnoid hemorrhage, Patent ductus arteriosu... ORPHA:91387
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hyponatremia, Hyperkalemia, Hypovolemia, Abnormal circulating cholesterol concentration, Increase... ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hyponatremia, Hyperkalemia, Hypovolemia, Abnormal circulating cholesterol concentration, Increase... ORPHA:289548
Microvillus Inclusion Disease
Hypovolemia ORPHA:2290
Ovarian Hyperstimulation Syndrome
Hypovolemia, Capillary leak ORPHA:64739
Isolated Permanent Neonatal Diabetes Mellitus
Neonatal insulin-dependent diabetes mellitus, Hyperglycemia, Hypovolemia, Glycosuria ORPHA:99885
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Shock, Hyponatremia, Acne, Hypovolemia, Hyperkalemia, Hypochloremia, Hypotension, Neonatal hypogl... ORPHA:90794
Proximal Renal Tubular Acidosis
Hypokalemia, Hypovolemia, Bicarbonaturia, Glycosuria ORPHA:47159
Fanconi Anemia, Complementation Group C
Prolonged G2 phase of cell cycle, Bone marrow hypocellularity OMIM:227645
Fanconi Anemia, Complementation Group D2
Patent ductus arteriosus, Prolonged G2 phase of cell cycle, Bone marrow hypocellularity OMIM:227646
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle OMIM:600901
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle OMIM:227650
Nasu-Hakola Disease
Acute leukemia ORPHA:2770
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2
OMIM:618193
Behavioral Variant Of Frontotemporal Dementia
ORPHA:275864
Progressive Non-Fluent Aphasia
ORPHA:100070
Semantic Dementia
ORPHA:100069
Early-Onset Autosomal Dominant Alzheimer Disease
ORPHA:1020
Amyotrophic Lateral Sclerosis
ORPHA:803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trem2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trem2.

There are 37 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology (December 2023) Trem2tm1(KOMP)Vlcg 38147777
Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease. BMC genomics (April 2023) Trem2tm1(KOMP)Vlcg PMC10074678
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation (February 2023) Trem2tm1(KOMP)Vlcg PMC9909920
TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD. Cells (January 2023) Trem2tm1(KOMP)Vlcg PMC9913311
Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination. Journal of neuroinflammation (November 2022) Trem2tm1(KOMP)Vlcg PMC9635103
Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy. Frontiers in immunology (November 2022) Trem2tm1(KOMP)Vlcg PMC9664165
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. Nature aging (September 2022) Trem2tm1(KOMP)Vlcg PMC10154216
Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease. Cell reports (May 2022) Trem2tm1(KOMP)Vlcg 35649351
TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice. Journal of Alzheimer's disease : JAD (January 2022) Trem2tm1(KOMP)Vlcg PMC8898080
TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease. Cell reports (December 2021) Trem2tm1(KOMP)Vlcg 34965428
Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival. Frontiers in immunology (March 2021) Trem2tm1(KOMP)Vlcg PMC8027073
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology. Neuron (March 2021) Trem2tm1(KOMP)Vlcg 33675684
The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of disease (September 2020) Trem2tm1(KOMP)Vlcg PMC7808254
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model. The Journal of experimental medicine (September 2020) Trem2tm1(KOMP)Vlcg PMC7478730
Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition. Journal of neuroinflammation (August 2020) Trem2tm1(KOMP)Vlcg PMC7427742
TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities. Cell death & disease (August 2020) Trem2tm1(KOMP)Vlcg PMC7442838
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta neuropathologica (August 2020) Trem2tm1(KOMP)Vlcg PMC7498497
Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (July 2020) Trem2tm1(KOMP)Vlcg 32613609
Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. eLife (June 2020) Trem2tm1(KOMP)Vlcg PMC7367682
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience (January 2020) Trem2tm1(KOMP)Vlcg PMC7046459
TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia (July 2019) Trem2tm1(KOMP)Vlcg 31265185
Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (June 2019) Trem2tm1c(EUCOMM)Wtsi 31219699
Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections. Nature methods (July 2018) Trem2tm1(KOMP) PMC6071422
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Molecular neurodegeneration (June 2018) Trem2tm1(KOMP)Vlcg PMC5984804
Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain. Neurobiology of aging (May 2018) Trem2tm1(KOMP)Vlcg PMC6075941
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron (March 2018) Trem2tm1(KOMP)Vlcg 29518356
Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945. Acta neuropathologica communications (February 2018) Trem2tm1(KOMP)Vlcg PMC5815182
Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal. Human molecular genetics (January 2018) Trem2tm1(KOMP)Vlcg PMC5886290
Practical considerations for choosing a mouse model of Alzheimer's disease. Molecular neurodegeneration (December 2017) Trem2tm1c(EUCOMM)Wtsi PMC5741956
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy. Molecular neurodegeneration (October 2017) Trem2tm1(KOMP)Vlcg PMC5644120
TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Frontiers in aging neuroscience (June 2017) Trem2tm1(KOMP)Vlcg PMC5478682
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience (January 2017) Trem2tm1(KOMP)Vlcg PMC5320608
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience (January 2017) Trem2tm1(KOMP)Vlcg PMC5242410
Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury. Journal of neurotrauma (May 2016) Trem2tm1(KOMP)Vlcg 26976047
Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging (March 2016) Trem2tm1(KOMP)Vlcg PMC4857884
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of biological chemistry (September 2015) Trem2tm1(KOMP)Vlcg PMC4646257
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. The Journal of experimental medicine (March 2015) Trem2tm1(KOMP)Vlcg PMC4354365

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MGI Allele Allele Type Produced
Trem2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Trem2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Trem2tm96949(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Trem2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Trem2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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