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Gene: Ncstn MGI:1891700

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
nicastrin
Synonyms:
Nct,  9430068N19Rik,  D1Dau13e,  nicastrin

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ncstn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ncstn by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Acne Inversa, Familial, 1
OMIM:142690

The table below shows human diseases predicted to be associated to Ncstn by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lambert Syndrome
Intrauterine growth retardation, Branchial anomaly ORPHA:1296
Verheij Syndrome
Branchial cyst, Short neck, Coloboma, Intrauterine growth retardation, Truncus arteriosus OMIM:615583
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula OMIM:609166
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
X-Linked Mandibulofacial Dysostosis
Branchial anomaly, Webbed neck ORPHA:1131
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst ORPHA:435938
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula ORPHA:50815
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Increased nuchal translucency, Coloboma, Branchial anomaly, Intrauterine growth retardation, Cyst... ORPHA:453499
Branchiootic Syndrome
Branchial fistula ORPHA:52429
Holoprosencephaly
Encephalocele, Short neck, Hydrocephalus, Spinal dysraphism, Branchial anomaly, Holoprosencephaly... ORPHA:2162
Bor Syndrome
Branchial cyst ORPHA:107
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula OMIM:113650
Oligomeganephronia
Branchial cyst, Optic disc coloboma ORPHA:2260
Distal 22Q11.2 Microduplication Syndrome
Branchial fistula, Patent ductus arteriosus, Optic disc coloboma, Hydrocephalus, Low posterior ha... ORPHA:261337
Treacher-Collins Syndrome
Encephalocele, Branchial fistula, Patent ductus arteriosus, Iris coloboma ORPHA:861
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Increased nuchal translucency, Coloboma, Branchial anomaly, Cystic hygroma ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Increased nuchal translucency, Coloboma, Branchial anomaly, Cystic hygroma ORPHA:352665
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly ORPHA:466950
Distal 22Q11.2 Microdeletion Syndrome
Branchial fistula, Truncus arteriosus, Intrauterine growth retardation ORPHA:261330
Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome
Branchial cyst, Natal tooth, Optic disc coloboma, Intrauterine growth retardation, Iris coloboma OMIM:620186
8Q24.3 Microdeletion Syndrome
Branchial cyst, Short neck, Patent ductus arteriosus, Retinal coloboma, Intrauterine growth retar... ORPHA:508488
Branchiooculofacial Syndrome
Short neck, Low posterior hairline, Branchial anomaly, Retinal coloboma, Intrauterine growth reta... OMIM:113620
Witteveen-Kolk Syndrome
Branchial fistula, Iris coloboma, Intrauterine growth retardation OMIM:613406
Craniofacial Microsomia 1
Patent ductus arteriosus, Occipital encephalocele, Branchial anomaly, Hydrocephalus OMIM:164210
Acne Inversa, Familial, 1
OMIM:142690

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ncstn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ncstn.

No publications found that use IMPC mice or data for Ncstn.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ncstntm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Ncstnem1(IMPC)Ccpcz Exon Deletion Mice
Ncstntm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ncstntm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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