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Gene: Ackr2 MGI:1891697

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
atypical chemokine receptor 2
Synonyms:
chemokine decoy receptor D6,  Ccbp2,  D6

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ackr2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ackr2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Acne Inversa, Familial, 3
Chronic furunculosis, Recurrent cutaneous abscess formation, Perifolliculitis, Acne inversa OMIM:613737
Lymphoblastic Transformation, Intrinsic Defect In
Chronic mucocutaneous candidiasis OMIM:247450
Lymphoblastic Transformation, Inhibition Of
Chronic mucocutaneous candidiasis OMIM:247430
Lymphokine Deficiency
Chronic mucocutaneous candidiasis OMIM:247650
Candidiasis, Familial, 6
Chronic mucocutaneous candidiasis OMIM:613956
Acne Inversa, Familial, 1
Acne inversa OMIM:142690
Chilblain Lupus 2
Chilblains OMIM:614415
Linear Atrophoderma Of Moulin
Pruritus, Inflammatory abnormality of the skin ORPHA:140933
Benign Cephalic Histiocytosis
Inflammatory abnormality of the skin, Skin rash ORPHA:157997
Immunodeficiency 51
Recurrent skin infections, Eczema, Pneumonia, Pustule, Chronic mucocutaneous candidiasis, Recurre... OMIM:613953
Paget Disease, Extramammary
Eczematoid dermatitis OMIM:167300
Dissecting Cellulitis Of The Scalp
Pruritus, Recurrent skin infections ORPHA:345
Kerion Celsi
Recurrent cutaneous abscess formation, Inflammatory abnormality of the skin, Recurrent skin infec... ORPHA:499
Intellectual Developmental Disorder, Fra12A Type
Erythroderma OMIM:136630
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Chronic furunculosis, Cutaneous abscess OMIM:619986
Erythroderma, Lethal Congenital
Congenital exfoliative erythroderma OMIM:227090
Erythema Nodosum, Familial
Erythema nodosum OMIM:132990
Perifolliculitis Capitis Abscedens Et Suffodiens, Familial
Perifolliculitis OMIM:260910
Chronic Actinic Dermatitis
Late onset atopic dermatitis, Eczema, Allergic rhinitis, Pruritus, Erythroderma ORPHA:330064
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Chronic furunculosis, Recurrent cutaneous abscess formation, Perifolliculitis, Acne inversa OMIM:613736
Erythroderma Desquamativum
Seborrheic dermatitis ORPHA:314
Bullous Diffuse Cutaneous Mastocytosis
Pruritus, Erythroderma ORPHA:280785
Ichthyosis, Congenital, Autosomal Recessive 7
Erythroderma OMIM:615022
Seborrhea-Like Dermatitis With Psoriasiform Elements
Seborrheic dermatitis OMIM:610227
Candidiasis, Familial, 8
Chronic oral candidiasis, Blepharitis, Cheilitis, Seborrheic dermatitis OMIM:615527
Pityriasis Rubra Pilaris
Pruritus, Pustule, Eczema, Erythroderma ORPHA:2897
Mannose-Binding Lectin Deficiency
Recurrent skin infections OMIM:614372
Erythrokeratodermia Variabilis Et Progressiva 1
Erythroderma OMIM:133200
Verrucous Hemangioma
Inflammatory abnormality of the skin ORPHA:464318
Lymphatic Malformation 3
Recurrent skin infections OMIM:613480
Epidermolytic Hyperkeratosis 1
Erythroderma OMIM:113800
Familial Reactive Perforating Collagenosis
Perifolliculitis, Inflammatory abnormality of the skin, Maculopapular exanthema, Pruritus, Crusti... ORPHA:79147
Complement Component C1R/C1S Deficiency
Discoid lupus rash, Arthritis, Nephritis OMIM:216950
Erythrokeratodermia Variabilis Et Progressiva 6
Pruritus, Superficial dermal perivascular inflammatory infiltrate OMIM:618531
Immunodeficiency 15A
Chronic mucocutaneous candidiasis, Recurrent sinusitis, Recurrent otitis media, Acne inversa, Cut... OMIM:618204
Ige Responsiveness, Atopic
Eczema, Allergic rhinitis OMIM:147050
Keratolytic Winter Erythema
Pustule ORPHA:50943
Inflammatory Bowel Disease 28, Autosomal Recessive
Perianal abscess, Enterocolitis, Folliculitis, Pyoderma, Colitis, Crohn's disease OMIM:613148
Ichthyosis, Congenital, Autosomal Recessive 10
Erythroderma OMIM:615024
Epidermolytic Hyperkeratosis 2
Erythroderma OMIM:620150
Mental Retardation And Psoriasis
Psoriasiform dermatitis OMIM:309480
Chronic Recurrent Multifocal Osteomyelitis 3
Palmoplantar pustulosis, Osteomyelitis OMIM:259680
Quinquaud Folliculitis Decalvans
Pustule, Recurrent skin infections ORPHA:346
Immunodeficiency 66
Pustule, Recurrent skin infections OMIM:618847
Epidermodysplasia Verruciformis
Pustule, Recurrent skin infections, Seborrheic dermatitis ORPHA:302
Erosive Pustular Dermatosis Of The Scalp
Pustule ORPHA:222
Complement Component 5 Deficiency
Generalized seborrheic dermatitis OMIM:609536
Immunodeficiency 104
Pneumonia, Eczema, Chronic mucocutaneous candidiasis, Otitis media, Recurrent otitis media OMIM:608971
Bullous Impetigo
Pustule, Recurrent bacterial skin infections, Septic arthritis ORPHA:36237
Congenital Ichthyosiform Erythroderma
Keratitis, Erythroderma, Pruritus ORPHA:79394
Agammaglobulinemia 9, Autosomal Recessive
Eczematoid dermatitis, Seborrheic dermatitis OMIM:619693
Ichthyosis Prematurity Syndrome
Pruritus, Allergic rhinitis, Erythroderma OMIM:608649
Inflammatory Skin And Bowel Disease, Neonatal, 1
Pustule, Blepharitis, Erythroderma OMIM:614328
Congenital Lethal Erythroderma
Congenital exfoliative erythroderma ORPHA:1954
Deafness, Neural, With Atypical Atopic Dermatitis
Late onset atopic dermatitis OMIM:221700
Alopecia-Intellectual Disability Syndrome 4
Erythroderma OMIM:618840
Peeling Skin Syndrome 1
Pruritus, Erythroderma OMIM:270300
Proteasome-Associated Autoinflammatory Syndrome 5
Skin rash OMIM:619175
Immunodeficiency 50
Eczema OMIM:300988
Elastoderma
Erysipelas, Eczema ORPHA:228240
Dermatitis, Atopic
Recurrent skin infections, Allergic rhinitis, Eczema, Pruritus, Atopic dermatitis, Conjunctivitis OMIM:603165
Autosomal Dominant Epidermolytic Ichthyosis
Erythroderma ORPHA:312
Hydroa Vacciniforme
Superficial dermal perivascular inflammatory infiltrate, Eczema, Keratitis, Malar rash, Papuloves... ORPHA:330058
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Chronic oral candidiasis, Pneumonia, Recurrent pneumonia, Hepatitis, Otitis media, Erythroderma ORPHA:169160
Pressure-Induced Localized Lipoatrophy
Inflammatory abnormality of the skin ORPHA:90160
Pemphigus Foliaceus
Psoriasiform dermatitis, Pruritus, Pustule, Crusting erythematous dermatitis, Erythroderma ORPHA:79481
Drug Reaction With Eosinophilia And Systemic Symptoms
Skin rash, Pustule, Myocarditis, Hepatitis, Thyroiditis, Tubulointerstitial nephritis, Interstiti... ORPHA:139402
Copper Deficiency, Familial Benign
Seborrheic dermatitis OMIM:121270
Psoriasis 15, Pustular, Susceptibility To
Psoriasiform dermatitis OMIM:616106
Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections
Recurrent otitis media, Recurrent skin infections, Atopic dermatitis, Cutaneous abscess OMIM:618944
Interstitial Granulomatous Dermatitis With Arthritis
Pruritus, Inflammatory abnormality of the skin, Rheumatoid arthritis ORPHA:79099
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2
Acne, Seborrheic dermatitis OMIM:614441
Mycosis Fungoides
Pruritus, Psoriasiform dermatitis, Eczema OMIM:254400
Pellagra-Like Syndrome
Skin rash OMIM:260650
Chilblain Lupus
Inflammatory abnormality of the skin, Skin rash, Discoid lupus rash, Pruritis on hand, Malar rash ORPHA:90280
Inflammatory Bowel Disease 25, Autosomal Recessive
Perianal abscess, Pancolitis, Folliculitis, Enterocolitis OMIM:612567
Ichthyosis, Hystrix-Like, With Deafness
Punctate keratitis, Erythroderma OMIM:602540
Ichthyosis With Confetti
Pruritus, Erythroderma OMIM:609165
Netherton Syndrome
Recurrent skin infections, Allergic rhinitis, Eczema, Chronic rhinitis, Erythroderma OMIM:256500
Porphyria Cutanea Tarda, Type I
Eczema OMIM:176090
Mal De Meleda
Inflammatory abnormality of the skin, Superficial dermal perivascular inflammatory infiltrate ORPHA:87503
Zinc Deficiency, Transient Neonatal
Eczema OMIM:608118
Immunodeficiency 58
Recurrent cutaneous abscess formation, Eczema, Allergic rhinitis, Seborrheic dermatitis, Recurren... OMIM:618131
Ichthyosis, Congenital, Autosomal Recessive 5
Erythroderma OMIM:604777
Ameloonychohypohidrotic Syndrome
Seborrheic dermatitis OMIM:104570
Lymphoproliferative Syndrome, X-Linked, 2
Acne, Recurrent skin infections, Erythema nodosum, Hepatitis, Folliculitis, Inflammation of the l... OMIM:300635
Lamellar Ichthyosis
Chronic otitis media, Pruritus, Erythroderma ORPHA:313
Ichthyosis, Congenital, Autosomal Recessive 9
Erythroderma OMIM:615023
Immunodeficiency 85 And Autoimmunity
Oligoarthritis, Eczema, Erythroderma OMIM:619510
Papa Syndrome
Increased inflammatory response, Myositis, Acne, Pustule, Arthritis, Crohn's disease ORPHA:69126
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Glomerulonephritis, Eczema, Hepatitis, Arthritis, Erythroderma OMIM:304790
Immunodeficiency 25
Recurrent pneumonia, Erythroderma OMIM:610163
Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant
Acne, Seborrheic dermatitis OMIM:167100
Generalized Pustular Psoriasis
Pustule, Cheilitis, Uveitis, Arthritis, Palmoplantar pustulosis, Erythroderma ORPHA:247353
Wiskott-Aldrich Syndrome 2
Eczema OMIM:614493
Hyper-Ige Syndrome 3, Autosomal Recessive, With Recurrent Infections
Osteomyelitis, Recurrent skin infections, Eczema, Pruritus, Recurrent pneumonia, Bronchiectasis, ... OMIM:618282
Juvenile Arthritis
Skin rash OMIM:618795
Ichthyosis, Congenital, Autosomal Recessive 1
Erythroderma OMIM:242300
Panniculitis-Induced Localized Lipodystrophy
Inflammatory abnormality of the skin ORPHA:90159
Spinocerebellar Ataxia 34
Erythroderma OMIM:133190
Omenn Syndrome
Pruritus, Pneumonia, Thyroiditis, Erythroderma ORPHA:39041
Netherton Syndrome
Skin rash, Eczema, Erythroderma ORPHA:634
Sézary Syndrome
Pruritus, Erythroderma ORPHA:3162
Harlequin Ichthyosis
Erythroderma ORPHA:457
Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige
Psoriasiform dermatitis, Recurrent skin infections, Eosinophilic infiltration of the esophagus, E... OMIM:615508
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Psoriasiform dermatitis, Eczema, Thyroiditis, Erythroderma, Chronic oral candidiasis OMIM:606367
Ichthyosis, Congenital, Autosomal Recessive 6
Erythroderma OMIM:612281
Idiopathic Localized Lipodystrophy
Pruritus, Inflammatory abnormality of the skin ORPHA:90158
Familial Hemophagocytic Lymphohistiocytosis
Skin rash, Maculopapular exanthema, Colitis, Erythroderma, Infectious encephalitis ORPHA:540
Bathing Suit Ichthyosis
Erythroderma ORPHA:100976
Diffuse Cutaneous Mastocytosis
Pruritus, Erythroderma ORPHA:79456
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Conjunctivitis, Erythroderma OMIM:242150
Neutropenia, Severe Congenital, X-Linked
Eczema OMIM:300299
Letterer-Siwe Disease
Stomatitis, Seborrheic dermatitis OMIM:246400
Biotinidase Deficiency
Skin rash, Conjunctivitis, Recurrent skin infections, Seborrheic dermatitis OMIM:253260
Congenital Disorder Of Glycosylation, Type If
Erythroderma OMIM:609180
Protoporphyria, Erythropoietic, 1
Pruritus, Eczema OMIM:177000
Peeling Skin Syndrome 6
Pruritus, Atopic dermatitis OMIM:618084
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenitis, Inflammation of the large intestine, Eczema, Erythroderma OMIM:615895
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Erythroderma ORPHA:169154
Omenn Syndrome
Pneumonia, Erythroderma OMIM:603554
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Arthritis, Eczematoid dermatitis, Seborrheic dermatitis OMIM:259100
Yao Syndrome
Inflammatory abnormality of the skin, Pericarditis, Skin rash, Arthritis, Keratoconjunctivitis sicca OMIM:617321
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Recurrent otitis media, Inflammatory abnormality of the skin, Sinusitis, Recurrent pneumonia ORPHA:277
Majeed Syndrome
Inflammatory abnormality of the skin, Osteomyelitis, Skin rash OMIM:609628
Rat-Bite Fever
Pericarditis, Maculopapular exanthema, Skin rash, Erythema nodosum, Lymphadenitis, Pustule, Myoca... ORPHA:31205
Transketolase Deficiency
Conjunctivitis, Uveitis, Seborrheic dermatitis ORPHA:488618
X-Linked Dominant Chondrodysplasia Punctata
Erythroderma ORPHA:35173
Pachydermoperiostosis
Osteomyelitis, Acne, Seborrheic dermatitis, Arthritis, Eczematoid dermatitis ORPHA:2796
Vexas Syndrome
Inflammatory abnormality of the skin, Neutrophilic infiltration of the skin, Chondritis of pinna,... OMIM:301054
Centrifugal Lipodystrophy
Lymphadenitis, Inflammatory abnormality of the skin ORPHA:90156
Hyperzincemia With Functional Zinc Depletion
Skin rash OMIM:601979
Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities
Erythroderma OMIM:617425
Trichothiodystrophy 1, Photosensitive
Keratoconjunctivitis sicca, Erythroderma OMIM:601675
Sapho Syndrome
Psoriasiform dermatitis, Acne, Osteomyelitis, Skin rash, Recurrent skin infections, Pustule, Syno... ORPHA:793
Idiopathic Hypereosinophilic Syndrome
Inflammatory abnormality of the skin, Eczema, Cholangitis, Pruritus, Chronic hepatitis, Arthritis... ORPHA:3260
Chondrodysplasia Punctata 2, X-Linked Dominant
Erythroderma OMIM:302960
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
Seborrheic dermatitis OMIM:210210
Majeed Syndrome
Inflammatory abnormality of the skin, Osteomyelitis, Acne, Pustule, Synovitis, Abnormal inflammat... ORPHA:77297
Graft Versus Host Disease
Fasciitis, Myositis, Maculopapular exanthema, Pneumonia, Inflammatory abnormality of the skin, Ga... ORPHA:39812
Trichothiodystrophy
Congenital exfoliative erythroderma, Keratoconjunctivitis sicca, Conjunctivitis, Eczema ORPHA:33364
Melkersson-Rosenthal Syndrome
Inflammatory abnormality of the skin, Cheilitis ORPHA:2483
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Myositis, Psoriasiform dermatitis, Osteomyelitis, Eczema, Pneumonia, Recurrent skin infections, G... ORPHA:37042
Uremic Pruritus
Pruritus, Inflammatory abnormality of the skin, Recurrent skin infections ORPHA:94059
Intellectual Disability-Seizures-Macrocephaly-Obesity Syndrome
Eczema, Seborrheic dermatitis ORPHA:369950
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Aspiration pneumonia, Seborrheic dermatitis OMIM:301072
Hemihyperplasia-Multiple Lipomatosis Syndrome
Seborrheic dermatitis ORPHA:276280
Monosomy 22
Seborrheic dermatitis ORPHA:96123
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Pruritus, Superficial dermal perivascular inflammatory infiltrate, Eczema, Seborrheic dermatitis ORPHA:83617
22Q11.2 Deletion Syndrome
Chronic otitis media, Arthritis, Acne, Seborrheic dermatitis ORPHA:567
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Seborrheic dermatitis OMIM:300868
Thrombocytopenia-Absent Radius Syndrome
Seborrheic dermatitis OMIM:274000
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Keratitis, Recurrent skin infections, Eczema, Erythroderma OMIM:308205
Digeorge Syndrome
Acne, Seborrheic dermatitis, Recurrent pneumonia, Recurrent sinusitis, Recurrent otitis media OMIM:188400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ackr2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ackr2.

No publications found that use IMPC mice or data for Ackr2.

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MGI Allele Allele Type Produced
Ackr2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ackr2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ackr2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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