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Gene: Kcnk6 MGI:1891291

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
potassium inwardly-rectifying channel, subfamily K, member 6
Synonyms:
Toss,  Twik2,  D7Ertd764e

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Kcnk6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Kcnk6 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hypertension, Essential
Elevated mean arterial pressure, Elevated systolic blood pressure, Elevated diastolic blood pressure OMIM:145500
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Osteochondrodysplasia, Rhizomelic, With Callosal Agenesis, Thrombocytopenia, Hydrocephalus, And Hypertension
Hypertension OMIM:166990
Pheochromocytoma/Paraganglioma Syndrome 6
Hypertension OMIM:618464
Coronary Artery Disease, Autosomal Dominant, 1
Hypertension, Myocardial infarction OMIM:608320
Polycystic Kidney Disease 7
Hypertension OMIM:620056
Preeclampsia/Eclampsia 1
Hypertension OMIM:189800
Melorheostosis With Osteopoikilosis
Hypertension ORPHA:1879
Spastic Paraplegia-Nephritis-Deafness Syndrome
Hypertension ORPHA:2820
Brachydactyly-Arterial Hypertension Syndrome
Hypertension ORPHA:1276
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 2
Lacunar stroke, Hypertension, Transient ischemic attack OMIM:616779
Nail-Patella-Like Renal Disease
Hypertension ORPHA:2613
Hypertension And Brachydactyly Syndrome
Hypertension OMIM:112410
Hyperaldosteronism, Familial, Type Iv
Hypertension OMIM:617027
Trimethylaminuria
Hypertension, Tachycardia OMIM:602079
Iga Nephropathy, Susceptibility To, 3
Hypertension OMIM:616818
Cystic Hamartoma Of Lung And Kidney
Hypertension ORPHA:2111
Focal Segmental Glomerulosclerosis 5
Hypertension OMIM:613237
Iga Nephropathy, Susceptibility To, 2
Hypertension OMIM:613944
Focal Segmental Glomerulosclerosis 3, Susceptibility To
Hypertension OMIM:607832
Coronary Artery Disease, Autosomal Dominant 2
Sudden cardiac death, Hypertension, Myocardial infarction OMIM:610947
Angiomatosis, Diffuse Corticomeningeal, Of Divry And Van Bogaert
Hypertension, Telangiectases producing 'marbled' skin OMIM:206570
Focal Segmental Glomerulosclerosis 2
Hypertension OMIM:603965
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894
Cardiomyopathy-Cataract-Hip Spine Disease Syndrome
Pulmonary embolism, Congestive heart failure, Hypertension, Hypertrophic cardiomyopathy, Arrhythmia ORPHA:1345
Renal Failure, Progressive, With Hypertension
Hypertension OMIM:161900
Atrial Fibrillation, Familial, 14
ST segment elevation, Paroxysmal atrial fibrillation, Hypertension, Prolonged PR interval OMIM:615378
Hyperaldosteronism, Familial, Type Ii
Hypertension OMIM:605635
Moyamoya Disease With Early-Onset Achalasia
Raynaud phenomenon, Hypertension ORPHA:401945
Glomerulopathy With Fibronectin Deposits 1
Hypertension OMIM:137950
Liddle Syndrome
Hypertension, Arrhythmia, Cerebral ischemia ORPHA:526
Polycystic Kidney Disease 5
Hypertension OMIM:617610
Lessel-Kubisch Syndrome
Hypertension OMIM:618681
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Hypertension OMIM:605115
Iga Nephropathy, Susceptibility To, 1
Hypertension OMIM:161950
Pseudohypoaldosteronism, Type Iia
Hypertension OMIM:145260
Morbid Obesity And Spermatogenic Failure
Congestive heart failure, Hypertension, Myocardial infarction OMIM:615703
Moyamoya Disease 6 With Or Without Achalasia
Raynaud phenomenon, Hypertension, Achalasia, Ischemic stroke OMIM:615750
Grange Syndrome
Aortic regurgitation, Hypertension ORPHA:79094
Obesity Due To Melanocortin 4 Receptor Deficiency
Hypertension ORPHA:71529
Phosphoribosylpyrophosphate Synthetase Superactivity
Hypertension, Arrhythmia, Cardiomyopathy ORPHA:3222
Maternally-Inherited Diabetes And Deafness
Hypertension, Hypertrophic cardiomyopathy, Congestive heart failure, Arrhythmia ORPHA:225
Pulmonary Hypertension, Primary, 1
Elevated right atrial pressure, Right ventricular failure, Increased pulmonary vascular resistanc... OMIM:178600
Fibronectin Glomerulopathy
Hypertension, Cerebral hemorrhage ORPHA:84090
Primary Membranoproliferative Glomerulonephritis
Hypertension, Myocardial infarction ORPHA:54370
Denys-Drash Syndrome
Hypertension ORPHA:220
Moyamoya Disease 1
Inflammatory arteriopathy, Telangiectasia OMIM:252350
Pseudohypoaldosteronism Type 2
Hypertension ORPHA:757
Coproporphyria, Hereditary
Hypertension, Tachycardia OMIM:121300
Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease
Hypertension OMIM:600666
Hyperaldosteronism, Familial, Type I
Hypertension OMIM:103900
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Wolff-Parkinson-White syndrome, Congestive heart failure, Abnormal left ventricular function, Hyp... OMIM:540000
Amyloidosis, Familial Visceral
Hypertension OMIM:105200
Arterial Calcification, Generalized, Of Infancy, 2
Tricuspid regurgitation, Myocardial infarction, Congestive heart failure, Hypertension, Mitral re... OMIM:614473
Familial Cervical Artery Dissection
Transient ischemic attack, Subarachnoid hemorrhage, Recurrent cerebral hemorrhage, Hypertension, ... ORPHA:36382
Cutis Marmorata Telangiectatica Congenita
Hypertension, Telangiectasia OMIM:219250
Erythrocytosis, Familial, 1
Hypertension, Cerebral hemorrhage, Myocardial infarction OMIM:133100
Familial Partial Lipodystrophy, Köbberling Type
Hypertension ORPHA:79084
Senior-Loken Syndrome
Hypertension ORPHA:3156
Sneddon Syndrome
Intracranial hemorrhage, Hypertension ORPHA:820
Preeclampsia
Hypertension, Elevated systolic blood pressure, Elevated diastolic blood pressure ORPHA:275555
Pseudohypoaldosteronism, Type Iib
Hypertension OMIM:614491
Pseudohypoaldosteronism, Type Iid
Hypertension OMIM:614495
Liddle Syndrome 2
Hypertension OMIM:618114
Liddle Syndrome 3
Hypertension OMIM:618126
Adrenal Hyperplasia, Congenital, Due To 21-Hydroxylase Deficiency
Hypertension OMIM:201910
Glutaric Aciduria Iii
Hypertension OMIM:231690
Lipodystrophy, Familial Partial, Type 4
Hypertension OMIM:613877
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease
Hypertension, Mitral regurgitation OMIM:173900
Focal Segmental Glomerulosclerosis 1
Hypertension OMIM:603278
Adrenal Hyperplasia, Congenital, Due To 17-Alpha-Hydroxylase Deficiency
Hypertension OMIM:202110
Inflammatory Skin And Bowel Disease, Neonatal, 2
Hypertension OMIM:616069
Potocki-Shaffer Syndrome
Hypertension ORPHA:52022
Corticosteroid-Binding Globulin Deficiency
Hypertension, Hypotension OMIM:611489
Central Hypoventilation Syndrome, Congenital, 3
Episodic hypertension OMIM:619483
Nephronophthisis 18
Hypertension OMIM:615862
Liddle Syndrome 1
Hypertension OMIM:177200
Postorgasmic Illness Syndrome
Hypertension, Palpitations ORPHA:279947
X-Linked Hypohidrotic Ectodermal Dysplasia
Hypertension ORPHA:181
Pseudohypoaldosteronism, Type Iie
Hypertension OMIM:614496
Ganglioneuroma
Gastrointestinal hemorrhage, Hypertension ORPHA:251992
Polycystic Kidney Disease 6 With Or Without Polycystic Liver Disease
Hypertension OMIM:618061
Plin1-Related Familial Partial Lipodystrophy
Hypertension ORPHA:280356
Mitochondrial Dna-Related Cardiomyopathy And Hearing Loss
Hypertension, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Congestive heart failure ORPHA:1349
Sneddon Syndrome
Hypertension, Ischemic stroke, Cerebral hemorrhage OMIM:182410
Pheochromocytoma--Islet Cell Tumor Syndrome
Tachycardia, Cerebral hemorrhage, Congestive heart failure, Episodic hypertension, Positive regit... OMIM:171420
Polyarteritis Nodosa
Raynaud phenomenon, Cardiomyopathy, Pericarditis, Hypertension ORPHA:767
Familial Cerebral Saccular Aneurysm
Intracranial hemorrhage, Hypertension, Transient ischemic attack, Subarachnoid hemorrhage ORPHA:231160
Takayasu Arteritis
Myocardial infarction, Vasculitis, Hypertension, Cerebral ischemia, Pulmonary arterial hypertensi... ORPHA:3287
Methanol Poisoning
Myocardial infarction, Cerebral hemorrhage, Inflammatory arteriopathy, Permanent atrial fibrillat... ORPHA:31825
Abdominal Obesity-Metabolic Syndrome 4
Hypertension, Myocardial infarction OMIM:618620
Lipodystrophy, Familial Partial, Type 1
Hypertension OMIM:608600
Familial Hyperaldosteronism Type I
Intracranial hemorrhage, Hypertension, Epistaxis ORPHA:403
Pituitary Adenoma 1, Multiple Types
Hypertension, Cardiomyopathy OMIM:102200
Telangiectasia, Hereditary Hemorrhagic, Type 5
Spontaneous, recurrent epistaxis, Portal hypertension, Telangiectasia OMIM:615506
Apparent Mineralocorticoid Excess
Hypertension OMIM:218030
Cryoglobulinemia, Familial Mixed
Hypertension OMIM:123550
Nephroblastoma
Hypertension ORPHA:654
Idiopathic Non-Lupus Full-House Nephropathy
Hypertension ORPHA:567544
Systemic Lupus Erythematosus 17
Raynaud phenomenon, Mitral regurgitation, Hypertensive crisis OMIM:301080
Peripartum Cardiomyopathy
Tachycardia, Right ventricular failure, Cardiogenic shock, Congestive heart failure, Dilated card... ORPHA:563
Atherosclerosis-Deafness-Diabetes-Epilepsy-Nephropathy Syndrome
Hypertension ORPHA:1192
Coach Syndrome 2
Hypertension OMIM:619111
Isolated Ectopia Lentis
Hypertension ORPHA:1885
Coenzyme Q10 Deficiency, Primary, 8
Hypertension OMIM:616733
Moyamoya Angiopathy-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism Syndrome
Hypertension, Dilated cardiomyopathy, Ischemic stroke, Cerebral hemorrhage ORPHA:280679
Familial Hyperaldosteronism Type Ii
Intracranial hemorrhage, Hypertension, Epistaxis ORPHA:404
Familial Pseudohyperkalemia
Hypertension ORPHA:90044
Rhabdoid Tumor
Hypertension, Internal hemorrhage ORPHA:69077
Lipodystrophy, Familial Partial, Type 5
Hypertension OMIM:615238
Pseudoxanthoma Elasticum
Gastrointestinal hemorrhage, Angina pectoris, Congestive heart failure, Retinal hemorrhage, Renov... OMIM:264800
Ochoa Syndrome
Hypertension ORPHA:2704
Extracranial Carotid Artery Aneurysm
Subarachnoid hemorrhage, Vasculitis, Hypertension, Cerebral ischemia, Arteritis ORPHA:494424
Pseudohypoaldosteronism, Type Iic
Hypertension OMIM:614492
Glucocorticoid Resistance, Generalized
Hypertension OMIM:615962
Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy
Transient ischemic attack, Cerebral hemorrhage, Intracranial hemorrhage, Hypertension, Lacunar st... ORPHA:136
Juvenile Paget Disease
Hypertension ORPHA:2801
Aapoaiv Amyloidosis
Atrial flutter, Abnormal cardiac ventricular function, Atrial fibrillation, Cardiac conduction ab... ORPHA:439232
Lipodystrophy, Familial Partial, Type 6
Hypertension OMIM:615980
Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction
Hypertension, Tachycardia OMIM:613870
Multicentric Carpotarsal Osteolysis Syndrome
Hypertension OMIM:166300
Tako-Tsubo Cardiomyopathy
Prolonged QT interval, Atrial fibrillation, Mildly reduced left ventricular ejection fraction, An... ORPHA:66529
Pheochromocytoma/Paraganglioma Syndrome 3
Tachycardia, Palpitations, Hypertension associated with pheochromocytoma OMIM:605373
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Epistaxis, Intracranial hemorrhage, Hypertension, Palpitations, Abnormal T-wave ORPHA:231625
Familial Hyperaldosteronism Type Iii
Prolonged QT interval, Hypertension, Epistaxis, Intracranial hemorrhage ORPHA:251274
Paroxysmal Hemicrania
Hypertension ORPHA:157835
Non-Functioning Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Palpitations, Positive regitine blocking test, Sin... ORPHA:94080
Acquired Aneurysmal Subarachnoid Hemorrhage
Myocardial infarction, Cerebral hemorrhage, Congestive heart failure, Hypertension, Syncope, Isch... ORPHA:90065
Stiff Skin Syndrome
Hypertension ORPHA:2833
Riboflavin Transporter Deficiency
Hypertension ORPHA:97229
Polycythemia Vera
Gastrointestinal hemorrhage, Angina pectoris, Epistaxis, Portal hypertension, Pulmonary embolism,... ORPHA:729
Fanconi Renotubular Syndrome 5
Hypertension OMIM:618913
Acth-Independent Macronodular Adrenal Hyperplasia 2
Hypertension OMIM:615954
C3 Glomerulopathy
Hypertension ORPHA:329918
Ectopic Aldosterone-Producing Tumor
Hypertension, Epistaxis ORPHA:231632
Primary Unilateral Adrenal Hyperplasia
Hypertension, Palpitations, Epistaxis ORPHA:231580
Hyperaldosteronism, Familial, Type Iii
Hypertension OMIM:613677
Nephronophthisis 2
Hypertension, Pulmonary insufficiency OMIM:602088
Pulmonary Hypertension, Primary, 2
Increased pulmonary vascular resistance, Pulmonary arterial hypertension, Abnormally loud pulmoni... OMIM:615342
Heme Oxygenase 1 Deficiency
Hypertension, Epistaxis, Diffuse alveolar hemorrhage OMIM:614034
Renal Hypodysplasia/Aplasia 1
Hypertension OMIM:191830
Abdominal Obesity-Metabolic Syndrome 3
Hypertension, Myocardial infarction OMIM:615812
Gaucher Disease, Type I
Epistaxis, Hypertension, Mitral regurgitation, Pulmonary arterial hypertension, Aortic valve sten... OMIM:230800
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Hypertension OMIM:612924
Pheochromocytoma
Tachycardia, Cerebral hemorrhage, Congestive heart failure, Episodic hypertension, Positive regit... OMIM:171300
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Hypertension OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Hypertension OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Hypertension OMIM:612926
Arteriosclerosis, Severe Juvenile
Hypertension, Myocardial infarction OMIM:208060
Mercury Poisoning
Hypertension, Tachycardia, Hypotension ORPHA:330021
Arterial Calcification, Generalized, Of Infancy, 1
Hypertension, Dilated cardiomyopathy, Congestive heart failure, Myocardial infarction OMIM:208000
Stiff-Person Syndrome
Hypertension, Tachycardia OMIM:184850
Alagille Syndrome 2
Hypertension, Pulmonic stenosis OMIM:610205
Pseudo-Torch Syndrome 3
Hypertension, Cerebral hemorrhage OMIM:618886
Morgagni-Stewart-Morel Syndrome
Hypertension ORPHA:77296
Severe Neurodegenerative Syndrome With Lipodystrophy
Hypertension ORPHA:363400
Cirrhosis, Familial
Hypertension, Pulmonary arterial hypertension OMIM:215600
Infant Botulism
Hypertension, Cardiac arrest, Hypotension ORPHA:178478
Tetanus
Hypertension, Tachycardia, Bradycardia ORPHA:3299
Telangiectasia, Hereditary Hemorrhagic, Type 2
Conjunctival telangiectasia, Tongue telangiectasia, Palate telangiectasia, Fingerpad telangiectas... OMIM:600376
Nephronophthisis 1
Hypertension OMIM:256100
Pigmented Nodular Adrenocortical Disease, Primary, 4
Hypertension OMIM:615830
Fabry Disease
Angina pectoris, Transient ischemic attack, Myocardial infarction, Congestive heart failure, Hype... OMIM:301500
Alport Syndrome 2, Autosomal Recessive
Hypertension OMIM:203780
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Hypertension OMIM:612925
Pheochromocytoma/Paraganglioma Syndrome 1
Tachycardia, Palpitations, Hypertension associated with pheochromocytoma OMIM:168000
Frasier Syndrome
Hypertension ORPHA:347
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Epistaxis, Intracranial hemorrhage, Hypertension, Second degree atrioventricular block, Pulmonary... ORPHA:369929
Pulmonary Hypertension, Primary, 4
Atrial flutter, Pulmonary arterial hypertension with lack of acute response to NO challenge, Firs... OMIM:615344
Lipodystrophy, Familial Partial, Type 3
Hypertension OMIM:604367
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Hypertension, Second degree atrioventricular block, Pulmonary arterial hypertension OMIM:617021
Diffuse Cutaneous Systemic Sclerosis
Congestive heart failure, Telangiectasia of the skin, Pulmonary arterial hypertension, Hypertensi... ORPHA:220393
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Gastrointestinal hemorrhage, Raynaud phenomenon, Punctate vasculitis skin lesions, Telangiectasia... ORPHA:247691
Pseudoxanthoma Elasticum
Gastrointestinal hemorrhage, Angina pectoris, Telangiectasia of the skin, Sudden cardiac death, R... ORPHA:758
Moyamoya Disease 4 With Short Stature, Hypergonadotropic Hypogonadism, And Facial Dysmorphism
Hypertension, Dilated cardiomyopathy, Cerebral hemorrhage OMIM:300845
Multiple Endocrine Neoplasia, Type Iia
Hypertension, Palpitations OMIM:171400
Primary Aldosteronism, Seizures, And Neurologic Abnormalities
Hypertension, Second degree atrioventricular block, Pulmonary arterial hypertension OMIM:615474
Primary Progressive Freezing Gait
Hypertension ORPHA:75567
Adenine Phosphoribosyltransferase Deficiency
Hypertension, Atrial fibrillation ORPHA:976
Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type
Hypertension, Pulmonary arterial hypertension OMIM:613320
Monosomy 18P
Hypertension ORPHA:1598
Porphyria, Acute Intermittent
Hypertension, Tachycardia OMIM:176000
Acth-Independent Macronodular Adrenal Hyperplasia
Hypertension OMIM:219080
Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies
Hypertension OMIM:617763
Pigmented Nodular Adrenocortical Disease, Primary, 2
Hypertension OMIM:610475
Bardet-Biedl Syndrome
Hypertension ORPHA:110
Pparg-Related Familial Partial Lipodystrophy
Hypertension, Hypertrophic cardiomyopathy, Congestive heart failure ORPHA:79083
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Hypertension OMIM:613095
Familial Bicuspid Aortic Valve
Aortic regurgitation, Hypertension, Aortic valve stenosis, Heart murmur ORPHA:402075
Aortic Arch Interruption
Aortic regurgitation, Shock, Tricuspid regurgitation, Blood pressure substantially higher in arms... ORPHA:2299
Nephronophthisis-Like Nephropathy 1
Hypertension OMIM:613159
Apparent Mineralocorticoid Excess
Hypertension ORPHA:320
Multisystemic Smooth Muscle Dysfunction Syndrome
Hypertension, Pulmonary arterial hypertension, Hypoperistalsis OMIM:613834
Eosinophilic Granulomatosis With Polyangiitis
Recurrent intrapulmonary hemorrhage, Transient ischemic attack, Myocardial infarction, Congestive... ORPHA:183
Pulmonary Hypertension, Primary, 3
Increased pulmonary vascular resistance, Pulmonary arterial hypertension, Elevated pulmonary arte... OMIM:615343
Pediatric-Onset Graves Disease
Atrial fibrillation, Congestive heart failure, Hypertension, Palpitations, Sinus tachycardia ORPHA:525731
Carney Triad
Gastrointestinal hemorrhage, Hypertension, Tachycardia, Arrhythmia ORPHA:139411
Sporadic Pheochromocytoma/Secreting Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Palpitations, Positive regitine blocking test, Sin... ORPHA:276621
Serotonin Syndrome
Hypertension, Tachycardia, Hypotension ORPHA:43116
Neuroblastoma, Susceptibility To, 1
Hypertension OMIM:256700
Overlap Myositis
Raynaud phenomenon, Hypertension, Pulmonary arterial hypertension ORPHA:206572
Aorta Coarctation
Congestive heart failure, Hypertension, Pulmonary arterial hypertension ORPHA:1457
Methylcobalamin Deficiency Type Cble
Hypertension ORPHA:2169
Acquired Generalized Lipodystrophy
Cardiomyopathy, Abnormal cardiovascular system physiology, Hypertension ORPHA:79086
Tessadori-Bicknell-Van Haaften Neurodevelopmental Syndrome 1
Hypertension OMIM:619758
Simple Cryoglobulinemia
Gastrointestinal hemorrhage, Pericarditis, Myocardial infarction, Raynaud phenomenon, Congestive ... ORPHA:91139
Pigmented Nodular Adrenocortical Disease, Primary, 1
Hypertension OMIM:610489
Birk-Landau-Perez Syndrome
Hypertension OMIM:617595
Renal Hypoplasia
Hypertension ORPHA:93101
Coach Syndrome 1
Hypertension, Portal hypertension OMIM:216360
Joubert Syndrome 14
Intracranial hemorrhage, Hypertension OMIM:614424
Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Hypertension, Orthostatic hypotension, Tachycardia OMIM:223900
Pheochromocytoma/Paraganglioma Syndrome 4
Tachycardia, Palpitations, Hypertension associated with pheochromocytoma OMIM:115310
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Hypertension, Hypotension OMIM:174000
Acute Interstitial Pneumonia
Hypertension ORPHA:79126
Caudal Regression Syndrome
Hypertension ORPHA:3027
Alagille Syndrome
Hypertension, Telangiectasia of the skin ORPHA:52
Werner Syndrome
Hypertension, Telangiectasia of the skin, Congestive heart failure, Myocardial infarction ORPHA:902
Low Phospholipid-Associated Cholelithiasis
Hypertension ORPHA:69663
Renal Agenesis
Hypertension ORPHA:411709
Wagro Syndrome
Hypertension OMIM:612469
Paternal Uniparental Disomy Of Chromosome 1
Hypertension ORPHA:251004
Fabry Disease
Conjunctival telangiectasia, Bundle branch block, Angina pectoris, Transient ischemic attack, Tel... ORPHA:324
Adrenocortical Carcinoma
Hypertension, Palpitations ORPHA:1501
Cocaine Intoxication
Prolonged QT interval, Tachycardia, Prolonged QRS complex, Myocardial infarction, Diffuse alveola... ORPHA:90068
Livedoid Vasculopathy
Telangiectasia of the skin, Hypertension, Ischemic stroke ORPHA:542643
Autosomal Dominant Dopa-Responsive Dystonia
Hypertension ORPHA:98808
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Hypertension OMIM:235400
Schimke Immuno-Osseous Dysplasia
Transient ischemic attack, Congestive heart failure, Hypertension, Ischemic stroke, Cerebral isch... ORPHA:1830
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Hematemesis, Hypertension, Portal hypertension OMIM:263200
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Hypertension ORPHA:449291
Pituitary Adenoma 4, Acth-Secreting
Hypertension OMIM:219090
Ethylene Glycol Poisoning
Prolonged QT interval, Shock, Tachycardia, Atrial fibrillation, Congestive heart failure, Hyperte... ORPHA:31826
Alport Syndrome 1, X-Linked
Hypertension OMIM:301050
Arterial Tortuosity Syndrome
Aortic regurgitation, Hypertension, Ischemic stroke, Aortic valve stenosis, Telangiectases of the... OMIM:208050
Alstrom Syndrome
Hypertension, Dilated cardiomyopathy, Congestive heart failure OMIM:203800
Porphyria Variegata
Hypertension, Tachycardia ORPHA:79473
Schimke Immunoosseous Dysplasia
Hypertension, Cerebral ischemia, Pulmonary arterial hypertension, Transient ischemic attack OMIM:242900
Beta-Ketothiolase Deficiency
Hypertension, Hypotension ORPHA:134
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 2
Hypertension, Hypertrophic cardiomyopathy, Arrhythmia OMIM:614052
Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum
Hypertension, Atrioventricular block ORPHA:371428
Arterial Tortuosity Syndrome
Telangiectasia of the skin, Cardiac arrest, Myocardial infarction, Congestive heart failure, Myoc... ORPHA:3342
Sickle Cell Disease
Hypertension OMIM:603903
Seckel Syndrome 10
Hypertension, Congestive heart failure OMIM:617253
Neuropathy, Hereditary Sensory And Autonomic, Type Vi
Retinal hemorrhage, Hypertension, Tachycardia, Bradycardia OMIM:614653
Renal Hypoplasia, Bilateral
Hypertension ORPHA:97362
Lmna-Related Cardiocutaneous Progeria Syndrome
Congestive heart failure, Intracranial hemorrhage, Hypertension, Mitral regurgitation, Aortic val... ORPHA:363618
Aicardi-Goutieres Syndrome 9
Hypertension, Pericarditis, Increased blood pressure, Portal hypertension OMIM:619487
Familial Dysautonomia
Hypertension, Orthostatic hypotension, Tachycardia ORPHA:1764
Hereditary Pheochromocytoma-Paraganglioma
Cerebral hemorrhage, Congestive heart failure, Palpitations, Positive regitine blocking test, Sin... ORPHA:29072
Poliomyelitis
Hypertension, Hypovolemic shock, Hypotension ORPHA:2912
Familial Thoracic Aortic Aneurysm And Aortic Dissection
Aortic regurgitation, Transient ischemic attack, Subarachnoid hemorrhage, Hypovolemia, Abnormal l... ORPHA:91387
Combined Oxidative Phosphorylation Deficiency 15
Wolff-Parkinson-White syndrome, Hypertension, Shortened PR interval OMIM:614947
Fragile X-Associated Tremor/Ataxia Syndrome
Hypertension, Hypotension ORPHA:93256
Alport Syndrome 3A, Autosomal Dominant
Hypertension OMIM:104200
Gaisböck Syndrome
Angina pectoris, Myocardial infarction, Hypovolemia, Elevated diastolic blood pressure, Hypertension ORPHA:90041
Posterior Urethral Valve
Hypertension ORPHA:93110
Hereditary Amyloidosis With Primary Renal Involvement
Gastrointestinal hemorrhage, Hypertension, Congestive heart failure ORPHA:85450
Spondyloenchondrodysplasia
Raynaud phenomenon, Hypertension, Vasculitis ORPHA:1855
Glycogen Storage Disease Ic
Hypertension, Pulmonary arterial hypertension, Spider hemangioma OMIM:232240
Classic Homocystinuria
Gastrointestinal hemorrhage, Pulmonary embolism, Intracranial hemorrhage, Hypertension, Cerebral ... ORPHA:394
Idiopathic Steroid-Sensitive Nephrotic Syndrome With Secondary Steroid Resistance
Hypertension, Pulmonary embolism ORPHA:567546
Cutis Gyrata-Acanthosis Nigricans-Craniosynostosis Syndrome
Hypertension ORPHA:1555
Von Hippel-Lindau Syndrome
Hypertension OMIM:193300
Pituitary Apoplexy
Hypertension, Hypotension ORPHA:95613
Von Hippel-Lindau Disease
Myocardial infarction, Myocarditis, Abnormal left ventricular function, Cardiomyopathy, Hypertens... ORPHA:892
Xfe Progeroid Syndrome
Hypertension OMIM:610965
Neuroleptic Malignant Syndrome
Tachycardia, Pulmonary embolism, Hypertension, Bradycardia, Hypotension, Arrhythmia, Hypertensive... ORPHA:94093
Hemorrhagic Fever-Renal Syndrome
Shock, Tachycardia, Epistaxis, Hematemesis, Capillary leak, Intracranial hemorrhage, Hypertension... ORPHA:340
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Hypertension OMIM:612780
Lead Poisoning
Hypertension ORPHA:330015
Congenital Adrenal Hyperplasia Due To 11-Beta-Hydroxylase Deficiency
Intracranial hemorrhage, Hypertension ORPHA:90795
Igg4-Related Retroperitoneal Fibrosis
Budd-Chiari syndrome, Hypertension, Renovascular hypertension, Large vessel vasculitis ORPHA:49041
Nestor-Guillermo Progeria Syndrome
Right bundle branch block, Hypertension, Mitral regurgitation, Pulmonary arterial hypertension, S... OMIM:614008
Hurler Syndrome
Cardiomyopathy, Hypertension, Angina pectoris ORPHA:93473
Marfanoid-Progeroid-Lipodystrophy Syndrome
Hypertension OMIM:616914
Oligomeganephronia
Hypertension ORPHA:2260
Blau Syndrome
Hypertension, Pericarditis OMIM:186580
Glycogen Storage Disease Ia
Hypertension OMIM:232200
Scorpion Envenomation
Bundle branch block, Tachycardia, Cardiac conduction abnormality, Congestive heart failure, Myoca... ORPHA:466677
Autosomal Dominant Polycystic Kidney Disease
Hypertension ORPHA:730
Granulomatosis With Polyangiitis
Gastrointestinal hemorrhage, Pericarditis, Recurrent intrapulmonary hemorrhage, Angina pectoris, ... ORPHA:900
Crimean-Congo Hemorrhagic Fever
Bundle branch block, Tachycardia, Epistaxis, Diffuse alveolar hemorrhage, Hematemesis, Myocarditi... ORPHA:99827
Alkaptonuria
Hypertension, Myocardial infarction ORPHA:56
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Hypertension OMIM:202010
Galloway-Mowat Syndrome 3
Hypertension OMIM:617729
Apert Syndrome
Hypertension ORPHA:87
Carey-Fineman-Ziter Syndrome
Hypertensive crisis ORPHA:1358
Nelson Syndrome
Intracranial hemorrhage, Hypertension ORPHA:199244
Papillorenal Syndrome
Hypertension OMIM:120330
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Hypertension ORPHA:189427
Alexander Disease
Hypotension, Hypertension, Sudden cardiac death ORPHA:58
Acute Intermittent Porphyria
Hypertension, Tachycardia ORPHA:79276
Hallermann-Streiff Syndrome
Hypertension, Pulmonary arterial hypertension, Telangiectasia OMIM:234100
Denys-Drash Syndrome
Hypertension OMIM:194080
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Portal hypertension, Raynaud phenomenon, Vasculitis, Dilated cardiomyopathy, Hypertension OMIM:615688
Familial Osteodysplasia, Anderson Type
Hypertension ORPHA:2769
Glycogen Storage Disease Ib
Hypertension OMIM:232220
Senior-Boichis Syndrome
Hypertension, Portal hypertension ORPHA:84081
Cockayne Syndrome Type 1
Hypertension ORPHA:90321
Beare-Stevenson Cutis Gyrata Syndrome
Hypertension OMIM:123790
Generalized Glucocorticoid Resistance Syndrome
Hypertension ORPHA:786
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Hypertension, Myocardial infarction ORPHA:90038
Scalp-Ear-Nipple Syndrome
Hypertension ORPHA:2036
Lipodystrophy, Familial Partial, Type 2
Hypertension OMIM:151660
Alport Syndrome
Hypertension ORPHA:63
Hunter-Macdonald Syndrome
Aortic regurgitation, Hypertension, Mitral regurgitation OMIM:611962
Neurodevelopmental Disorder With Microcephaly, Cataracts, And Renal Abnormalities
Hypertension OMIM:617913
Aicardi-Goutieres Syndrome 7
Hematemesis, Vasculitis, Hematochezia, Hypertension, Hypertrophic cardiomyopathy OMIM:615846
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Hypertension ORPHA:90793
Postinfectious Vasculitis
Cerebral vasculitis, Raynaud phenomenon, Cardiomyopathy, Hypertension, Ischemic stroke, Vasculiti... ORPHA:48435
Homozygous Familial Hypercholesterolemia
Angina pectoris, Sudden cardiac death, Myocardial infarction, Heart murmur, Abnormal left ventric... ORPHA:391665
Bardet-Biedl Syndrome 1
Hypertension OMIM:209900
Xq21 Microdeletion Syndrome
Hypertension ORPHA:1435
Myhre Syndrome
Hypertension ORPHA:2588
Prader-Willi Syndrome
Hypertension ORPHA:739
Tsh-Secreting Pituitary Adenoma
Supraventricular arrhythmia, Congestive heart failure, Hypertension, Palpitations, Hypotension, V... ORPHA:91347
Systemic Lupus Erythematosus
Raynaud phenomenon, Hypertension ORPHA:536
Adams-Oliver Syndrome 1
Hypertension, Aortic valve stenosis, Pulmonary arterial hypertension, Pulmonic stenosis OMIM:100300
Acute Transverse Myelitis
Hypertension, Orthostatic hypotension, Subarachnoid hemorrhage ORPHA:139417
Immunodeficiency 87 And Autoimmunity
Hypertension, Third degree atrioventricular block, Dilated cardiomyopathy, Pulmonary arterial hyp... OMIM:619573
Pierson Syndrome
Hypertension, Retinal hemorrhage OMIM:609049
Au-Kline Syndrome
Hypertension OMIM:616580
Infection-Related Hemolytic Uremic Syndrome
Myocarditis, Hypertension, Hypertensive crisis ORPHA:544482
Neurofibromatosis, Type I
Hypertension OMIM:162200
Arima Syndrome
Hypertension OMIM:243910
Marshall-Smith Syndrome
Pulmonary arterial hypertension, Hypertension, Premature ventricular contraction OMIM:602535
Scalp-Ear-Nipple Syndrome
Supraventricular tachycardia, Hypertension, Congestive heart failure OMIM:181270
Pseudohypoparathyroidism Type 1A
Prolonged QT interval, Hypertension ORPHA:79443
Renal Dysplasia
Hypertension ORPHA:93108
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Hypertension, Pulmonary venous hypertension, Epistaxis ORPHA:79259
Mucopolysaccharidosis Type 2, Severe Form
Cardiomyopathy, Arrhythmia, Hypertension, Heart murmur ORPHA:217085
Mucopolysaccharidosis Type 2, Attenuated Form
Cardiomyopathy, Arrhythmia, Hypertension, Heart murmur ORPHA:217093
Orofaciodigital Syndrome I
Hypertension OMIM:311200
Blau Syndrome
Hypertension, Pericarditis, Pulmonary arterial hypertension, Large vessel vasculitis ORPHA:90340
Hutchinson-Gilford Progeria Syndrome
Aortic regurgitation, Mitral stenosis, Angina pectoris, Myocardial infarction, Transient ischemic... ORPHA:740
Bartter Syndrome Type 4
Hypertension ORPHA:89938
Paroxysmal Nocturnal Hemoglobinuria
Hypertension, Budd-Chiari syndrome, Myocardial infarction, Pulmonary embolism ORPHA:447
Cockayne Syndrome B
Hypertension, Arrhythmia OMIM:133540
Cockayne Syndrome A
Hypertension, Arrhythmia OMIM:216400
Keutel Syndrome
Hypertension, Pulmonic stenosis OMIM:245150
Mucopolysaccharidosis Type 2
Cardiomyopathy, Arrhythmia, Hypertension ORPHA:580
Orofaciodigital Syndrome Type 1
Hypertension ORPHA:2750
Tuberous Sclerosis Complex
Hypertension, Internal hemorrhage ORPHA:805
Short-Rib Thoracic Dysplasia 9 With Or Without Polydactyly
Hypertension OMIM:266920
Cushing Disease
Hypertension, Capillary fragility, Myocardial infarction ORPHA:96253
Acromegaly
Hypertension, Mitral regurgitation, Hypertrophic cardiomyopathy ORPHA:963
Somatomammotropinoma
Hypertension, Mitral regurgitation, Hypertrophic cardiomyopathy ORPHA:314769
Myhre Syndrome
Hypertension, Aortic valve stenosis OMIM:139210
Multiple Endocrine Neoplasia Type 2
Palpitations, Hypertensive crisis, Hypertension associated with pheochromocytoma ORPHA:653
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Hypertension, Portal hypertension ORPHA:731
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency
Hypertension ORPHA:95699
Congenital Disorder Of Glycosylation, Type Iim
Hypertension OMIM:300896
Cranioectodermal Dysplasia 2
Hypertension OMIM:613610
Hardikar Syndrome
Hematemesis, Hypertension, Portal hypertension OMIM:301068
Lipodystrophy, Familial Partial, Type 7
Hypertension, Orthostatic hypotension, Pulmonary arterial hypertension OMIM:606721
Atypical Werner Syndrome
Hypertension, Aortic valve stenosis, Telangiectasia of the skin, Congestive heart failure ORPHA:79474
17Q11 Microdeletion Syndrome
Telangiectasia of the skin, Renovascular hypertension, Hypertension, Pulmonic stenosis, Pulmonary... ORPHA:97685
Yunis-Varon Syndrome
Pulmonary arterial hypertension, Hypertension, Renovascular hypertension, Cardiomyopathy ORPHA:3472
Smith-Lemli-Opitz Syndrome
Hypertension, Hypertrophic cardiomyopathy, Ventricular fibrillation OMIM:270400
Cockayne Syndrome
Hypertension, Retinal hemorrhage ORPHA:191
Multiple Endocrine Neoplasia Type 1
Melena, Hypertension, Shortened QT interval, Hematemesis ORPHA:652
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Hypertension, Mitral regurgitation, Hypertrophic cardiomyopathy OMIM:220111
Neurofibromatosis Type 1
Hypertension ORPHA:636
Generalized Arterial Calcification Of Infancy
Transient ischemic attack, Retinal hemorrhage, Hypertension, Weak pulse, Left ventricular systoli... ORPHA:51608
Turner Syndrome Due To Structural X Chromosome Anomalies
Prolonged QT interval, Hypertension, Myocardial infarction ORPHA:99413
Turner Syndrome
Prolonged QT interval, Hypertension, Myocardial infarction ORPHA:881
Mosaic Monosomy X
Prolonged QT interval, Hypertension, Myocardial infarction ORPHA:99228
Monosomy X
Prolonged QT interval, Hypertension, Myocardial infarction ORPHA:99226
Williams Syndrome
Sudden cardiac death, Myocardial infarction, Congestive heart failure, Renovascular hypertension,... ORPHA:904
22Q11.2 Deletion Syndrome
Gastrointestinal hemorrhage, Corneal neovascularization, Hypertensive crisis ORPHA:567
Microcephalic Osteodysplastic Primordial Dwarfism, Type I
Hypertension OMIM:210710
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Hypertension, Corneal neovascularization OMIM:308205
Williams-Beuren Syndrome
Portal hypertension, Hypertension, Mitral regurgitation, Pulmonic stenosis, Supravalvular aortic ... OMIM:194050
Cushing Syndrome Due To Ectopic Acth Secretion
Hypertension, Capillary fragility, Myocardial infarction ORPHA:99889
Carney Complex
Hypertension, Congestive heart failure ORPHA:1359
Vascular Ehlers-Danlos Syndrome
Telangiectasia of the skin, Transient ischemic attack, Renovascular hypertension, Hypertension, I... ORPHA:286
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Hypertension OMIM:201750
Alström Syndrome
Portal hypertension, Congestive heart failure, Dilated cardiomyopathy, Hypertension, Abnormal cor... ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Kcnk6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kcnk6.

No publications found that use IMPC mice or data for Kcnk6.

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MGI Allele Allele Type Produced
Kcnk6tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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